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Tnk1 tyrosine kinase, non-receptor, 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303247, updated on 11-Apr-2024

Summary

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Official Symbol
Tnk1provided by RGD
Official Full Name
tyrosine kinase, non-receptor, 1provided by RGD
Primary source
RGD:1310113
See related
Ensembl:ENSRNOG00000015578 AllianceGenome:RGD:1310113
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Predicted to be located in cytosol and membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 24.8), Lung (RPKM 18.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55070362..55084383, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54571396..54580547, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56458650..56475183, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 256 Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 95 Neighboring gene potassium channel tetramerization domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. Hoare K, et al. Oncogene, 2003 Jun 5. PMID 12789265
  2. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Felschow DM, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873601
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
non-receptor tyrosine-protein kinase TNK1
NP_001100482.1
XP_006246766.1
XP_038941911.1
XP_063125103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107012.1 → NP_001100482.1  non-receptor tyrosine-protein kinase TNK1

    See identical proteins and their annotated locations for NP_001100482.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HFV1, D3ZJI4
    Conserved Domains (4) summary
    cd09539
    Location:16 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cl17036
    Location:395 → 436
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 380
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:625 → 664
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55070362..55084383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246704.5 → XP_006246766.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

    UniProtKB/TrEMBL
    D3ZJI4
    Conserved Domains (4) summary
    cd09539
    Location:89 → 140
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:192 → 451
    STYKc; Protein kinase; unclassified specificity
    cl21453
    Location:193 → 453
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:698 → 737
    UBA_like_SF; UBA domain-like superfamily

  2. XM_063269033.1 → XP_063125103.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

    UniProtKB/TrEMBL
    A6HFV1

  3. XM_039085983.2 → XP_038941911.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

    UniProtKB/TrEMBL
    A6HFV1, D3ZJI4
    Conserved Domains (4) summary
    cd09539
    Location:16 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cl17036
    Location:395 → 436
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 380
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:625 → 664
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein Strain
Heading Accession and Version

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