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Shisa5 shisa family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301013, updated on 13-Apr-2024

Summary

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Official Symbol
Shisa5provided by RGD
Official Full Name
shisa family member 5provided by RGD
Primary source
RGD:1359661
See related
Ensembl:ENSRNOG00000020667 AllianceGenome:RGD:1359661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable WW domain binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nuclear envelope. Predicted to be active in endoplasmic reticulum. Orthologous to human SHISA5 (shisa family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 248.7), Lung (RPKM 169.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118569975..118584880)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109691504..109706411)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117780992..117795923)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene uncharacterized LOC100911671 Neighboring gene uncharacterized LOC134480237 Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. Bourdon JC, et al. J Cell Biol, 2002 Jul 22. PMID 12135983, Free PMC Article
  2. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Ludes-Meyers JH, et al. Oncogene, 2004 Jun 24. PMID 15064722, Free PMC Article
  3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94600

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein shisa-5
Names
scotin
shisa homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006989.1 → NP_001006990.1  protein shisa-5 isoform 4

    See identical proteins and their annotated locations for NP_001006990.1

    Status: VALIDATED

    Source sequence(s)
    BC083710
    UniProtKB/Swiss-Prot
    Q5XIH2
    UniProtKB/TrEMBL
    A6I3A7, A6I3A9
    Related
    ENSRNOP00000053045.2, ENSRNOT00000056199.3
    Conserved Domains (1) summary
    pfam13908
    Location:2 → 86
    Shisa; Wnt and FGF inhibitory regulator

  2. NM_001395736.1 → NP_001382665.1  protein shisa-5 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K447
    Conserved Domains (1) summary
    pfam13908
    Location:38 → 201
    Shisa; Wnt and FGF inhibitory regulator

  3. NM_001395737.1 → NP_001382666.1  protein shisa-5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K447, A6I3A3
    Related
    ENSRNOP00000072905.2, ENSRNOT00000077236.2
    Conserved Domains (1) summary
    pfam13908
    Location:38 → 200
    Shisa; Wnt and FGF inhibitory regulator

  4. NM_001395738.1 → NP_001382667.1  protein shisa-5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K447

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118569975..118584880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243762.5 → XP_006243824.1  protein shisa-5 isoform X1

    See identical proteins and their annotated locations for XP_006243824.1

    UniProtKB/TrEMBL
    A6I3A8, A6I3B0
    Conserved Domains (1) summary
    pfam13908
    Location:14 → 98
    Shisa; Wnt and FGF inhibitory regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIH2.1 GenPept UniProtKB/Swiss-Prot:Q5XIH2

Gene LinkOut

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