Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pik3cgprovided by RGD
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gammaprovided by RGD
Primary source: RGD:1306468
See related: Ensembl:ENSRNOG00000009385 AllianceGenome:RGD:1306468
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pi3k
Summary: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 145.7), Spleen (RPKM 108.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (54494247..54529563, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (48766778..48802098, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (51465696..51501234, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-182 promotes apoptosis of neural cells in cerebral infarction rats by PI3K/AKT signaling pathway.
Title: MiR-182 promotes apoptosis of neural cells in cerebral infarction rats by PI3K/AKT signaling pathway.
MiR- 211 represses apoptosis of nerve cells in rats with cerebral infarction through PI3K/AKT signaling pathway.
Title: MiR- 211 represses apoptosis of nerve cells in rats with cerebral infarction through PI3K/AKT signaling pathway.
LIPUS-SCs-Exo promotes peripheral nerve regeneration in cavernous nerve crush injury-induced ED rats via PI3K/Akt/FoxO signaling pathway.
Title: LIPUS-SCs-Exo promotes peripheral nerve regeneration in cavernous nerve crush injury-induced ED rats via PI3K/Akt/FoxO signaling pathway.
The PI3K/mTOR/AKT pathway is known to regulate cell growth, survival, and proliferation and has more recently been shown to be a central mediator of HCC cell survival to heat stress.
Title: Heat Stress and Hepatic Laser Thermal Ablation Induce Hepatocellular Carcinoma Growth: Role of PI3K/mTOR/AKT Signaling.
Suggest that when cardiomyocytes incur oxidative stress under diabetic conditions, it subsequently activates the PI3Kgamma/Akt cell-signaling pathway and further increases HMGB1 expression.
Title: Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment.
Taken together, our results demonstrate that HPC appears to confer neuroprotection against retinal IRI via the PI3K/Akt pathway.
Title: Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway.
These findings suggested that exercise dampened the secretion of inflammation mediators probably through partial inhibition of TLR4 and p-NF-kappaB and activation of PI3K/p-Akt expression in the spleen.
Title: Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes.
Exendin-4 ameliorates HG-induced cardiomyocyte apoptosis, and the mechanisms may involve anti-oxidative stress via the HO-1/Nrf-2 system, as well as intervention of the PI3K/AKT signaling pathway.
Title: Attenuation of High Glucose-Induced Rat Cardiomyocyte Apoptosis by Exendin-4 via Intervention of HO-1/Nrf-2 and the PI3K/AKT Signaling Pathway.
The phosphatidylinositol 3-Kinases (PI3K)/signal transducer and activator of transcription 1 and 3 (STAT1/3) signaling pathway mediated high glucose (HG)-triggered extracellular matrix (ECM) accumulation and suppressor of cytokine signaling-3 (SOCS-3) upregulation in mesangial cells (RMCs).
Title: Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
This study investigates the role of peroxisome proliferator-activated receptor (PPAR)-gamma in hypothalamus-pituitary-adrenal axis A axis hyperactivity in diabetic rats.
Title: Activation of PPAR-γ reduces HPA axis activity in diabetic rats by up-regulating PI3K expression.

Submit: New GeneRIF Correction See all GeneRIFs (94)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in secretory granule localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IB	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IB	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Names: phosphoinositide-3-kinase, catalytic, gamma polypeptide

NP_001358229.1

EC 2.7.1.153

XP_003750188.1

EC 2.7.1.153

XP_006240065.1

EC 2.7.1.153

XP_006240066.1

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371300.3 → NP_001358229.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AKZ7, D3ZFJ0

Related

ENSRNOP00000012487.3, ENSRNOT00000012487.6

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

54494247..54529563 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240003.5 → XP_006240065.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

See identical proteins and their annotated locations for XP_006240065.1

UniProtKB/TrEMBL

A0A8I6AKZ7, D3ZFJ0

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_003750140.6 → XP_003750188.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

See identical proteins and their annotated locations for XP_003750188.1

UniProtKB/TrEMBL

A0A8I6AKZ7, D3ZFJ0

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_006240004.5 → XP_006240066.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

See identical proteins and their annotated locations for XP_006240066.1

UniProtKB/TrEMBL

A0A8I6AKZ7, D3ZFJ0

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106723.1: Suppressed sequence

Description

NM_001106723.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PIK3CG (GeneID:5294).