Glg1 golgi glycoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glg1provided by RGD
Official Full Name: golgi glycoprotein 1provided by RGD
Primary source: RGD:69345
See related: Ensembl:ENSRNOG00000018668 AllianceGenome:RGD:69345
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Selel; MG-160
Summary: Enables fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi medial cisterna. Orthologous to human GLG1 (golgi glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 355.7), Kidney (RPKM 332.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (56034248..56133538, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (39124892..39224178, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (42983879..43088074)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

under hypoxia, ESL-1 is shed from activated hepatic stellate cells
Title: Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X84037 (e-PCR)
- UniSTS:159819

RH138754 (e-PCR)
- UniSTS:220841

X84037 (e-PCR)
- UniSTS:125875

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bone morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Golgi apparatus protein 1

Names: E-selectin ligand 1; ESL-1; golgi sialoglycoprotein MG-160; selectin, endothelial cell, ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017211.2 → NP_058907.1 Golgi apparatus protein 1 precursor

See identical proteins and their annotated locations for NP_058907.1

Status: PROVISIONAL

Source sequence(s)

U08136

UniProtKB/Swiss-Prot

Q62638

UniProtKB/TrEMBL

A6IZ85, G3V8G5

Related

ENSRNOP00000025570.1, ENSRNOT00000025570.4

Conserved Domains (1) summary

pfam00839
Location:792 → 848

Cys_rich_FGFR; Cysteine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

56034248..56133538 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097676.2 → XP_038953604.1 Golgi apparatus protein 1 isoform X1

UniProtKB/TrEMBL

A6IZ85, G3V8G5

Conserved Domains (1) summary

pfam00839
Location:792 → 848

Cys_rich_FGFR; Cysteine rich repeat