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Mecr mitochondrial trans-2-enoyl-CoA reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 29470, updated on 11-Apr-2024

Summary

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Official Symbol
Mecrprovided by RGD
Official Full Name
mitochondrial trans-2-enoyl-CoA reductaseprovided by RGD
Primary source
RGD:3208
See related
Ensembl:ENSRNOG00000028047 AllianceGenome:RGD:3208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nrbf1
Summary
Enables signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 104.8), Heart (RPKM 93.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149313765..149339964)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144029684..144056373)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150001281..150027407)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, U Neighboring gene uncharacterized LOC134486998 Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder. Heimer G, et al. Am J Hum Genet, 2016 Dec 1. PMID 27817865, Free PMC Article
  2. Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II. Miinalainen IJ, et al. J Biol Chem, 2003 May 30. PMID 12654921
  3. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Masuda N, et al. Gene, 1998 Oct 23. PMID 9795230
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enoyl-[acyl-carrier-protein] reductase, mitochondrial
Names
2-enoyl thioester reductase
NRBF-1
nuclear receptor-binding factor 1
trans-2-enoyl-CoA reductase, mitochondrial
NP_058905.1
XP_063143328.1
XP_063143329.1
XP_063143330.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017209.1 → NP_058905.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_058905.1

    Status: PROVISIONAL

    Source sequence(s)
    AB015724
    UniProtKB/Swiss-Prot
    F1LPY7, Q9Z311
    UniProtKB/TrEMBL
    A0A140TAE6
    Related
    ENSRNOP00000031375.2, ENSRNOT00000034057.5
    Conserved Domains (2) summary
    cd08290
    Location:44 → 373
    ETR; 2-enoyl thioester reductase (ETR)
    COG0604
    Location:44 → 359
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    149313765..149339964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287260.1 → XP_063143330.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

  2. XM_063287259.1 → XP_063143329.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

  3. XM_063287258.1 → XP_063143328.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X1

RNA

  1. XR_005504375.2 RNA Sequence

  2. XR_010066346.1 RNA Sequence

  3. XR_005504376.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z311.1 GenPept UniProtKB/Swiss-Prot:Q9Z311

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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