Ptgir prostaglandin I2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgirprovided by RGD
Official Full Name: prostaglandin I2 receptorprovided by RGD
Primary source: RGD:1310890
See related: Ensembl:ENSRNOG00000016756 AllianceGenome:RGD:1310890
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable prostacyclin receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of platelet-derived growth factor receptor signaling pathway; and negative regulation of smooth muscle cell proliferation. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human PTGIR (prostaglandin I2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 46.2), Spleen (RPKM 30.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86707690..86710073)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77579596..77581979)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78833449..78835832)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The prostaglandin I(2) receptor receptor mRNA transcripts and protein were present in meningeal as well as in cerebral rat vasculature.
Title: Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system.
the expression of prostaglandin E(2) (EP(4)) and prostacyclin (IP) receptors in cultures of mixed dorsal root ganglia cells and in purified dorsal root ganglia glia
Title: Glial cells isolated from dorsal root ganglia express prostaglandin E(2) (EP(4)) and prostacyclin (IP) receptors.
Fetal programming of prostacyclin receptor in rats exposed in utero to maternal hyperglycemia results in impaired vasodilatation.
Title: In utero exposure to maternal diabetes impairs vascular expression of prostacyclin receptor in rat offspring.
Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.
Title: Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables prostacyclin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostacyclin receptor

Names: PGI receptor; PGI2 receptor; prostaglandin I receptor (IP); prostaglandin I2 (prostacyclin) receptor (IP); prostanoid IP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077644.1 → NP_001071112.1 prostacyclin receptor

See identical proteins and their annotated locations for NP_001071112.1

Status: PROVISIONAL

Source sequence(s)

D28966

UniProtKB/Swiss-Prot

P43253

UniProtKB/TrEMBL

A6J8D9

Related

ENSRNOP00000022461.2, ENSRNOT00000022461.4

Conserved Domains (2) summary

cd14964
Location:44 → 70

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:43 → 332

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily