Cav3 caveolin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cav3provided by RGD
Official Full Name: caveolin 3provided by RGD
Primary source: RGD:2281
See related: Ensembl:ENSRNOG00000005798 AllianceGenome:RGD:2281
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including nitric-oxide synthase binding activity; potassium channel inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of cellular component organization; and response to ischemia. Located in several cellular components, including T-tubule; cell surface; and neuromuscular junction. Part of protein-containing complex. Colocalizes with several cellular components, including Z disc; intercalated disc; and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); isolated elevated serum creatine phosphokinase levels; and muscle tissue disease (multiple). Orthologous to human CAV3 (caveolin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 777.1), Heart (RPKM 627.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (147137993..147153967)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (145582168..145598142)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (144382945..144398919)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERalphaDelta4, an ERalpha splice variant missing exon4, interacts with caveolin-3 and mGluR2/3.
Title: ERαΔ4, an ERα splice variant missing exon4, interacts with caveolin-3 and mGluR2/3.
In ventricular myocytes from normal hearts, regulation of the L-type Ca(2+) current by beta2-adrenoceptors and the constitutive regulation by caveolin-3 is localized to the t-tubules. In heart failure, the regulation of L-type Ca(2+) current by beta2-adrenoceptors is redistributed to the surface membrane, and the constitutive regulation by caveolin-3 is lost.
Title: Loss of caveolin-3-dependent regulation of I(Ca) in rat ventricular myocytes in heart failure.
Cav3 depletion in cardiac fibroblasts induced an increase in collagen content, cell proliferation, and phenotypic conversion of fibroblasts to myofibroblasts. Conversely, Cav3 overexpression in cardiac fibroblasts was shown to inhibit angiotensin II-mediated excessive collagen deposition through protein kinase C-epsilon inactivation.
Title: Abnormal Downregulation of Caveolin-3 Mediates the Pro-Fibrotic Action of MicroRNA-22 in a Model of Myocardial Infarction.
Suggest a novel role for striatin in regulating cardiomyocyte spontaneous contraction rate and the dynamics of the STRN/caveolin-3/calmodulin complex.
Title: Cardiac striatin interacts with caveolin-3 and calmodulin in a calcium sensitive manner and regulates cardiomyocyte spontaneous contraction rate.
Antioxidant N-acetylcysteine attenuated myocardial dysfunction and myocardial I/R injury by improving Cav-3/eNOS signaling.
Title: N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats.
Hypoxic preconditioning promotes the translocation of protein kinase C epsilon binding with caveolin-3 at cell membrane, not at mitochondrial one, in rat heart.
Title: Hypoxic preconditioning promotes the translocation of protein kinase C ε binding with caveolin-3 at cell membrane not mitochondrial in rat heart.
miR-22 down-regulated Cav3, leading to restored eNOS activity/NO production, which inhibited cardiac myocyte apoptosis and promoted cardiac function after myocardial ischemia and reperfusion.
Title: Cardiac myocyte-protective effect of microRNA-22 during ischemia and reperfusion through disrupting the caveolin-3/eNOS signaling.
MURC/cavin-4 requires its coiled-coil domain to target the plasma membrane and to stabilize Cav3 at the plasma membrane of cardiomyocytes
Title: The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.
Study suggests that molecular changes involving cav1, cav2 and cav3 occurring in endothelial cells following juvenile traumatic brain injury might participate in blood-brain barrier repair while, might serve other undefined roles in astrocytes
Title: Caveolin expression changes in the neurovascular unit after juvenile traumatic brain injury: signs of blood-brain barrier healing?
HLP forms a triple complex with RyR2 and caveolin-3. siRNA and adenovirus-mediated KD of HLP decreased the electrically evoked Ca(2+) release from the sarcoplasmic reticulum
Title: The molecular interaction of heart LIM protein (HLP) with RyR2 and caveolin-3 is essential for Ca(2+)-induced Ca(2+) release in the heart.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables connexin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables potassium channel inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in caveola assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within caveola assembly	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in detection of muscle stretch	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart trabecula formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane raft organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sarcomere organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleus localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of caveolin-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction by receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
part_of dystrophin-associated glycoprotein complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
colocalizes_with focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caveolin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.