Tnnc1 troponin C1, slow skeletal and cardiac type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnnc1provided by RGD
Official Full Name: troponin C1, slow skeletal and cardiac typeprovided by RGD
Primary source: RGD:1309921
See related: Ensembl:ENSRNOG00000018943 AllianceGenome:RGD:1309921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tncc
Summary: Enables calcium ion binding activity. Involved in cardiac muscle contraction; diaphragm contraction; and response to metal ion. Located in contractile fiber. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 19291.3) and Muscle (RPKM 4139.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6408607..6412070)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6400801..6405634)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7292207..7295238)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility
Title: TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.
Troponin C interaction with Troponin I in cardiac muscle
Title: The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR.
the interaction between cTnC and cTnI in skinned papillary muscle strips is dependent on sarcomere length
Title: Sarcomere length dependent effects on the interaction between cTnC and cTnI in skinned papillary muscle strips.
These findings provide new insights into the in vivo mechanism of Ca(2+) sensitization and demonstrate that directly targeting cTnC has significant potential in cardiovascular therapy.
Title: Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog.
These findings supported our hypothesis here that strong cross-bridge interactions with the cardiac thin filament exert a Ca(2+)-sensitizing effect on the CRS.
Title: Structural basis for the in situ Ca(2+) sensitization of cardiac troponin C by positive feedback from force-generating myosin cross-bridges.
the inhibitory effect of EGCg on myofilament Ca(2+) activation may be related to an enhanced Ca(2+)-Mg(2+)exchange at sites III and IV of cTnC, which might reduce the myosin crossbridge dependent component of thin filament activation.
Title: The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits magnesium binding to the C-domain of cardiac troponin C.
Calcium Binding Changes the Open-Closed Equilibrium of the regulatory N-domain of isolated cardiac troponin C.
Title: Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C.
Paramagnetic relaxation enhancement NMR reveals that isolated cardiac troponin C has considerable interdomain flexibility and preferentially adopts a bent conformation in solution, with a defined range of relative domain orientations.
Title: Interdomain orientation of cardiac troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state.
troponin C (cTnC) and tropomyosin (cTm) are not only present in myofilaments of ventricular cardiomyocytes in culture but are also within their nuclei
Title: Nuclear cardiac troponin and tropomyosin are expressed early in cardiac differentiation of rat mesenchymal stem cells.
The data suggest that in the absence of Ca(2+) at troponin C site II strong-binding myosin crossbridges cause the opening of more active sites on the thin filament if the C-domain is occupied by Mg(2+) rather than Ca(2+).
Title: The Ca2+/Mg2+ sites of troponin C modulate crossbridge-mediated thin filament activation in cardiac myofibrils.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI289970 (e-PCR)
- UniSTS:247064

Tncc (e-PCR), detects polymorphism
- UniSTS:238170

AI874626 (e-PCR)
- UniSTS:180625

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	ISO Inferred from Sequence Orthology more info
enables troponin T binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in diaphragm contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle filament sliding speed	ISO Inferred from Sequence Orthology more info
involved_in response to metal ion	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transition between fast and slow fiber	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cardiac Troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cardiac Troponin complex	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
part_of troponin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: troponin C, slow skeletal and cardiac muscles

Names: troponin C type 1 (slow); troponin C, cardiac/slow skeletal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034105.2 → NP_001029277.1 troponin C, slow skeletal and cardiac muscles

See identical proteins and their annotated locations for NP_001029277.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6A4Q5, E9PTA1, Q4PP99

Related

ENSRNOP00000086929.1, ENSRNOT00000094646.1

Conserved Domains (1) summary

PTZ00184
Location:9 → 157

PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

6408607..6412070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094265.2 → XP_038950193.1 troponin C, slow skeletal and cardiac muscles isoform X1

UniProtKB/TrEMBL

A0A8I6A4Q5, A0A8J8XJV6

Related

ENSRNOP00000025606.6

Conserved Domains (1) summary

PTZ00184
Location:4 → 152

PTZ00184; calmodulin; Provisional