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Pgm2 phosphoglucomutase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289632, updated on 30-Mar-2024

Summary

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Official Symbol
Pgm2provided by RGD
Official Full Name
phosphoglucomutase 2provided by RGD
Primary source
RGD:1306061
See related
Ensembl:ENSRNOG00000002185 AllianceGenome:RGD:1306061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphoglucomutase activity and phosphopentomutase activity. Predicted to act upstream of or within glucose metabolic process. Orthologous to human PGM2 (phosphoglucomutase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 171.3), Spleen (RPKM 104.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (44519906..44553420, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (44166314..44199828, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (45829440..45863883, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 1 Neighboring gene uncharacterized LOC120096609 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family. Maliekal P, et al. J Biol Chem, 2007 Nov 2. PMID 17804405
  2. A phylogenetic approach to the identification of phosphoglucomutase genes. Whitehouse DB, et al. Mol Biol Evol, 1998 Apr. PMID 9549096
  3. Evolutionary evidence for a regulator gene controlling the lactate dehydrogenase B gene in rodent erythrocytes. Shows TB, et al. Biochem Genet, 1969 Dec. PMID 5392465
  4. Phosphoglucomutase isozymes of red cells in Mus musculus: additional polymorphism at PGM-l compared by two electrophoretic systems. Miner GD, et al. Biochem Genet, 1972 Dec. PMID 4646763
  5. A null mutation at the mouse Phosphoglucomutase-1 locus and a new locus Pgm-3. Johnson FM, et al. Biochem Genet, 1981 Jun. PMID 6457600

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglucomutase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphopentomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopentomutase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in purine ribonucleoside salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphopentomutase
NP_001099477.2
XP_006251059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106007.3 → NP_001099477.2  phosphopentomutase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8J8XT82, B1H277, F7FLB2
    Related
    ENSRNOP00000002977.7, ENSRNOT00000002977.6
    Conserved Domains (1) summary
    PTZ00150
    Location:19 → 620
    PTZ00150; phosphoglucomutase-2-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    44519906..44553420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250997.5 → XP_006251059.1  phosphopentomutase isoform X1

    UniProtKB/TrEMBL
    B1H277, F7FLB2
    Conserved Domains (2) summary
    cd05799
    Location:1 → 538
    PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...
    PTZ00150
    Location:1 → 558
    PTZ00150; phosphoglucomutase-2-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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