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Atp8a1 ATPase phospholipid transporting 8A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289615, updated on 25-Apr-2024

Summary

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Official Symbol
Atp8a1provided by RGD
Official Full Name
ATPase phospholipid transporting 8A1provided by RGD
Primary source
RGD:1309619
See related
Ensembl:ENSRNOG00000034200 AllianceGenome:RGD:1309619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylserine flippase activity. Predicted to be involved in learning; positive regulation of cell migration; and regulation of membrane lipid distribution. Is integral component of synaptic vesicle membrane. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 314.3), Lung (RPKM 276.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p11
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (40668932..40911465)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (40315013..40557572)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (41972398..42210555)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glutaredoxin and cysteine rich domain containing 1 Neighboring gene uncharacterized LOC120096602 Neighboring gene uncharacterized LOC134481745 Neighboring gene shisa family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning. Levano K, et al. J Neurochem, 2012 Jan. PMID 22007859, Free PMC Article
  2. ATP8A1 activity and phosphatidylserine transbilayer movement. Soupene E, et al. J Receptor Ligand Channel Res, 2008. PMID 20224745, Free PMC Article
  3. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article
  4. Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. Kato U, et al. J Biol Chem, 2013 Feb 15. PMID 23269685, Free PMC Article
  5. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine flippase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aminophospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in learning ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase IA
Names
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
probable phospholipid-transporting ATPase IA
NP_001413924.1
XP_006251042.1
XP_038948654.1
XP_038948656.1
XP_038948657.1
XP_038948658.1
XP_063128992.1
XP_063128993.1
XP_063128994.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426995.2 → NP_001413924.1  phospholipid-transporting ATPase IA

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6AVY6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    40668932..40911465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092730.2 → XP_038948658.1  phospholipid-transporting ATPase IA isoform X4

    UniProtKB/TrEMBL
    A6JDA0
    Related
    ENSRNOP00000097076.1
    Conserved Domains (1) summary
    TIGR01652
    Location:49 → 1096
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  2. XM_063272922.1 → XP_063128992.1  phospholipid-transporting ATPase IA isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZXX6

  3. XM_063272923.1 → XP_063128993.1  phospholipid-transporting ATPase IA isoform X6

  4. XM_039092726.2 → XP_038948654.1  phospholipid-transporting ATPase IA isoform X1

    UniProtKB/TrEMBL
    A6JDA0
    Conserved Domains (1) summary
    TIGR01652
    Location:94 → 1131
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  5. XM_039092729.2 → XP_038948657.1  phospholipid-transporting ATPase IA isoform X3

    UniProtKB/TrEMBL
    A6JDA0
    Conserved Domains (1) summary
    TIGR01652
    Location:94 → 1116
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  6. XM_039092728.2 → XP_038948656.1  phospholipid-transporting ATPase IA isoform X2

    UniProtKB/TrEMBL
    A6JDA0
    Conserved Domains (1) summary
    TIGR01652
    Location:94 → 1131
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

  7. XM_006250980.4 → XP_006251042.1  phospholipid-transporting ATPase IA isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZKC1
    Related
    ENSRNOP00000077596.1
    Conserved Domains (5) summary
    TIGR01484
    Location:489 → 654
    HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
    TIGR01494
    Location:14 → 716
    ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
    pfam13246
    Location:322 → 417
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:663 → 915
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:632 → 661
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  8. XM_063272924.1 → XP_063128994.1  phospholipid-transporting ATPase IA isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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