ITPR2 inositol 1,4,5-trisphosphate receptor type 2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ITPR2provided by VGNC
Official Full Name: inositol 1,4,5-trisphosphate receptor type 2provided by VGNC
Primary source: VGNC:VGNC:30347
See related: Ensembl:ENSBTAG00000002313
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: insP3R2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (82983248..83574976)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_36226-36227:1064517122:1 (e-PCR)
- UniSTS:467038

MARC_36228-36229:1065623914:1 (e-PCR)
- UniSTS:467039

MARC_36230-36231:1064518668:1 (e-PCR)
- UniSTS:467040

MARC_36232-36233:1064518911:1 (e-PCR)
- UniSTS:467041

MARC_36236-36237:1064578949:1 (e-PCR)
- UniSTS:467042

MARC_36238-36239:1064579242:1 (e-PCR)
- UniSTS:467043

MARC_36240-36241:1064579670:1 (e-PCR)
- UniSTS:467044

MARC_36244-36245:1064587916:1 (e-PCR)
- UniSTS:467045

MARC_36246-36247:1064588530:1 (e-PCR)
- UniSTS:467046

MARC_36248-36249:1064588818:1 (e-PCR)
- UniSTS:467047

MARC_36250-36251:1065013276:1 (e-PCR)
- UniSTS:467048

MARC_36254-36255:1065014112:1 (e-PCR)
- UniSTS:467049

MARC_36260-36261:1065015996:1 (e-PCR)
- UniSTS:467050

MARC_36262-36263:1065029539:1 (e-PCR)
- UniSTS:467051

MARC_36264-36265:1065628178:1 (e-PCR)
- UniSTS:467052

BZ831509 (e-PCR)
- UniSTS:475328

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate receptor type 2

Names: IP3 receptor; IP3R 2; inositol 1,4,5-triphosphate receptor, type 2; type 2 InsP3 receptor; type 2 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174369.2 → NP_776794.1 inositol 1,4,5-trisphosphate receptor type 2

See identical proteins and their annotated locations for NP_776794.1

Status: PROVISIONAL

Source sequence(s)

AF402600

UniProtKB/Swiss-Prot

Q8WN96

UniProtKB/TrEMBL

F1N137

Related

ENSBTAP00000095957.1, ENSBTAT00000119607.1

Conserved Domains (7) summary

smart00472
Location:294 → 336

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2306 → 2552

Ion_trans; Ion transport protein

pfam01365
Location:475 → 665

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 432

MIR; MIR domain

pfam08454
Location:1917 → 2022

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

cl07918
Location:2257 → 2437

Virul_fac_BrkB; Virulence factor BrkB

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

Range

82983248..83574976

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024991354.2 → XP_024847122.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X2

UniProtKB/TrEMBL

A0A3Q1N7P8, F1N137

Related

ENSBTAP00000066830.1, ENSBTAT00000074865.2

Conserved Domains (5) summary

pfam00520
Location:2306 → 2552

Ion_trans; Ion transport protein

pfam01365
Location:473 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 432

MIR; MIR domain

pfam08454
Location:1917 → 2022

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_059886107.1 → XP_059742090.1 inositol 1,4,5-trisphosphate receptor type 2 isoform X1