PTTG3P pituitary tumor-transforming 3, pseudogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTTG3Pprovided by HGNC
Official Full Name: pituitary tumor-transforming 3, pseudogeneprovided by HGNC
Primary source: HGNC:HGNC:13422
See related: Ensembl:ENSG00000213005 AllianceGenome:HGNC:13422
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PTTG3; PTTG1P3; rcPTTG1
Summary: Predicted to enable SH3 domain binding activity. Predicted to be involved in homologous chromosome segregation and negative regulation of mitotic sister chromatid separation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 8q13.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (66767329..66768034, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (67193098..67193803, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (67679564..67680269, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia-induced PTTG3P contributes to colorectal cancer glycolysis and M2 phenotype of macrophage.
Title: Hypoxia-induced PTTG3P contributes to colorectal cancer glycolysis and M2 phenotype of macrophage.
Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients.
Title: Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients.
The lncRNA PTTG3P promotes the progression of CRPC via upregulating PTTG1.
Title: The lncRNA PTTG3P promotes the progression of CRPC via upregulating PTTG1.
Study found that PTTG3P was up-regulated in hepatocellular carcinoma (HCC) tissues and cells. Functional experiments demonstrated that knockdown of PTTG3P inhibited cell proliferation, migration and invasion, and promoted cell apoptosis, acting as an oncogene. Mechanistically, PTTG3P upregulated the expression of miR-383 targets CCND1 and PARP2 by sponging miR-383, acting as a competing endogenous RNA.
Title: Long non-coding RNA PTTG3P functions as an oncogene by sponging miR-383 and up-regulating CCND1 and PARP2 in hepatocellular carcinoma.
Data provide evidence that up-regulation of PTTG3P might be a valuable prognostic marker for hepatocellular carcinoma (HCC). Altered expression of PTTG3P could be important for tumorigenesis and progression of HCC. It promotes tumor growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in HCC.
Title: The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.
PTTG3P promotes gastric tumour cell proliferation and invasion and is an indicator of poor prognosis.
Title: PTTG3P promotes gastric tumour cell proliferation and invasion and is an indicator of poor prognosis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in homologous chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_002734.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC011031, AF095289

Related

ENST00000521862.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

66767329..66768034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

67193098..67193803 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_021000.1: Suppressed sequence

Description

NM_021000.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.