Adora2a adenosine A2a receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adora2aprovided by RGD
Official Full Name: adenosine A2a receptorprovided by RGD
Primary source: RGD:2049
See related: Ensembl:ENSRNOG00000001302 AllianceGenome:RGD:2049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: A2ar; ADENO; Adora2l1
Summary: Enables G protein-coupled adenosine receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of secretion. Located in several cellular components, including axolemma; postsynaptic density; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with intermediate filament. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 73.9), Lung (RPKM 63.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (13315270..13332802, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (13315848..13333386, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (14265251..14282873, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abeta1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes.
Title: Aβ(1-42) peptides blunt the adenosine A(2A) receptor-mediated control of the interplay between P(2)X(7) and P(2)Y(1) receptors mediated calcium responses in astrocytes.
Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor.
Title: Regulation of hippocampal postnatal and adult neurogenesis by adenosine A(2A) receptor: Interaction with brain-derived neurotrophic factor.
Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor.
Title: Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor.
The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats.
Title: The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats.
Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.
Title: Regulation of adenosine A(2A) receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.
Low androgen status inhibits the AKT/eNOS/cGMP signaling pathways and the production of cAMP in the corpus cavernosum of castrated rats by downregulating the expression of A2B receptor with no significant difference in the expression of A2A receptor, and results in decreased of intra-cavernous pressure/mean arterial pressure.
Title: Effect of low androgen status on the expression of adenosine A(2A) and A(2B) receptors in rat penile corpus cavernosum.
Studied effect of exercise on memory and cerebral cortex physiology of NTPDase-1 (CD39), 5' nucleotidase ecto (CD73), and adenosine A2a receptor (A2ar).
Title: Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression.
results show that A2A receptors exert a positive postsynaptic modulatory effect over synaptic, but not extrasynaptic, NMDA receptors in CA1 neurons and, therefore, under non-pathological conditions may contribute to shift the dual role of NMDA receptors towards enhancement of synaptic plasticity
Title: Adenosine A(2A) receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons.
Chronic blockade of adenosine A2A receptors, ameliorated cognitive deficits, but not anxiety-like behavior in a model of anxiety and cognitive dysfunction.
Title: Region-specific control of microglia by adenosine A(2A) receptors: uncoupling anxiety and associated cognitive deficits in female rats.
These results demonstrate that acute alpha2-adrenergic stimulation suppresses glucose oxidation in beta-cells independent of nutrient availability and insulin exocytosis, while cAMP concentrations are elevated.
Title: Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells.

Submit: New GeneRIF Correction See all GeneRIFs (143)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled adenosine receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled adenosine receptor activity	TAS Traceable Author Statement more info	PubMed
enables alpha-actinin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 5 metabotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled adenosine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in astrocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eating behavior	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of alpha-beta T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to alkaloid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in response to caffeine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenosine receptor A2a

Names: Adenosine A2a-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357942.1 → NP_001344871.1 adenosine receptor A2a uORF5

Status: VALIDATED

Description

Transcript Variant: This transcript includes two overlapping open reading frames encoding different proteins, with distinct amino acid compositions (A2AR and uORF5, PMID:24293369). Both proteins are upregulated under hypoxic conditions. This RefSeq represents the shorter protein, uORF5.

Source sequence(s)

BC081727, CR477522
NM_053294.5 → NP_445746.3 adenosine receptor A2a A2AR

See identical proteins and their annotated locations for NP_445746.3

Status: VALIDATED

Description

Transcript Variant: This transcript includes two overlapping open reading frames encoding different proteins, with distinct amino acid compositions (A2AR and uORF5, PMID:24293369). Both proteins are upregulated under hypoxic conditions. This RefSeq represents the longer protein, A2AR, which is conserved across species.

Source sequence(s)

BC081727, CR477522

UniProtKB/Swiss-Prot

P30543

UniProtKB/TrEMBL

A6JKL4

Related

ENSRNOP00000001759.2, ENSRNOT00000001759.4

Conserved Domains (1) summary

cd15068
Location:4 → 294

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

13315270..13332802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601552.3 → XP_017457041.1 adenosine receptor A2a isoform X1

UniProtKB/Swiss-Prot

P30543

UniProtKB/TrEMBL

A6JKL4

Conserved Domains (1) summary

cd15068
Location:4 → 294

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063278978.1 → XP_063135048.1 adenosine receptor A2a isoform X3
XM_039098459.2 → XP_038954387.1 adenosine receptor A2a isoform X2

Conserved Domains (2) summary

cd14964
Location:11 → 29

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:2 → 187

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily