Bmp4 bone morphogenetic protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25296, updated on 11-Apr-2024

Summary

Official Symbol: Bmp4provided by RGD
Official Full Name: bone morphogenetic protein 4provided by RGD
Primary source: RGD:2213
See related: Ensembl:ENSRNOG00000009694 AllianceGenome:RGD:2213
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BOMPR4A
Summary: Enables growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 119.9), Kidney (RPKM 75.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (22098191..22113145, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (19618538..19633494, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (20776060..20791013, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation.
Title: Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation.
Hypermethylation of the Bmp4 promoter dampens binding of HIF-1alpha and impairs its cardiac protective effects from oxidative stress in prenatally GC-exposed offspring.
Title: Hypermethylation of the Bmp4 promoter dampens binding of HIF-1α and impairs its cardiac protective effects from oxidative stress in prenatally GC-exposed offspring.
BMP-4 impedes endothelial cell migration in neointimal hyperplasia via FoXO-3 specific modulation of reactive oxygen species.
Title: BMP-4 impedes endothelial cell migration in neointimal hyperplasia via FoXO-3 specific modulation of reactive oxygen species.
Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina.
Title: Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina.
Bone morphogenetic proteins in biomineralization of two endodontic restorative cements.
Title: Bone morphogenetic proteins in biomineralization of two endodontic restorative cements.
The role of bone morphogenetic protein 4 in corneal injury repair.
Title: The role of bone morphogenetic protein 4 in corneal injury repair.
Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats.
Title: Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats.
Acute upregulation of bone morphogenetic protein-4 regulates endogenous cell response and promotes cell death in spinal cord injury.
Title: Acute upregulation of bone morphogenetic protein-4 regulates endogenous cell response and promotes cell death in spinal cord injury.
reductions in BMP4 expression were possibly responsible for dysfunction of the lumbosacral spinal cord during late developmental stages in anorectal malformations fetal rats
Title: Bone morphogenetic protein 4 expression in the developing lumbosacral spinal cord of rat embryos with anorectal malformations.
elevated serum BMP-2 and BMP-4 levels may serve as serum markers for chronic kidney disease vascular calcification.
Title: Bone Morphogenetic Proteins 2/4 Are Upregulated during the Early Development of Vascular Calcification in Chronic Kidney Disease.

Submit: New GeneRIF Correction See all GeneRIFs (71)

General gene information

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Markers

UniSTS:496641 (e-PCR)
- UniSTS:496641

Bmp4 (e-PCR), detects polymorphism
- UniSTS:496641

D14Mit129 (e-PCR), detects polymorphism
- UniSTS:127234

RH94860 (e-PCR)
- UniSTS:120106

BMP4_296 (e-PCR)
- UniSTS:277036

PMC156609P1 (e-PCR)
- UniSTS:271413

Bmp4 (e-PCR), detects polymorphism
- UniSTS:532293

PMC34552P3 (e-PCR)
- UniSTS:273224

Bmp4 (e-PCR), detects polymorphism
- UniSTS:141181

UniSTS:497280 (e-PCR)
- UniSTS:497280

Bmp4 (e-PCR), detects polymorphism
- UniSTS:497280

Bmp4 (e-PCR), detects polymorphism
- UniSTS:532664

Bmp4 (e-PCR), detects polymorphism
- UniSTS:265413

Bmp4 (e-PCR), detects polymorphism
- UniSTS:478950

Bmp4 (e-PCR), detects polymorphism
- UniSTS:526068

MARC_5761-5762:996690803:2 (e-PCR)
- UniSTS:269563

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP receptor binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISS Inferred from Sequence or Structural Similarity more info
enables co-receptor binding	IEA Inferred from Electronic Annotation more info
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in ameloblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of ameloblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in anatomical structure regression	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in apoptotic process involved in endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in branching involved in prostate gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in bronchus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bronchus development	ISO Inferred from Sequence Orthology more info
involved_in bud dilation involved in lung branching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bud dilation involved in lung branching	ISO Inferred from Sequence Orthology more info
involved_in bud elongation involved in lung branching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bud elongation involved in lung branching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in cardiac jelly development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to thyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in coronary vasculature development	IEA Inferred from Electronic Annotation more info
involved_in coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in cranial suture morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cranial suture morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in deltoid tuberosity development	IEA Inferred from Electronic Annotation more info
involved_in deltoid tuberosity development	ISO Inferred from Sequence Orthology more info
involved_in deltoid tuberosity development	ISS Inferred from Sequence or Structural Similarity more info
involved_in dorsal/ventral neural tube patterning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
involved_in embryonic cranial skeleton morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal joint morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic skeletal joint morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion development	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion development	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	IEA Inferred from Electronic Annotation more info
involved_in endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in epithelial tube branching involved in lung morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial-mesenchymal cell signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial-mesenchymal cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelium development	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
involved_in glomerular capillary formation	IEA Inferred from Electronic Annotation more info
involved_in glomerular capillary formation	ISO Inferred from Sequence Orthology more info
involved_in glomerular capillary formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart induction	IEA Inferred from Electronic Annotation more info
involved_in heart induction	ISO Inferred from Sequence Orthology more info
involved_in heart induction	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner ear auditory receptor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intermediate mesodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intermediate mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intermediate mesodermal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lens induction in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens induction in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lung lobe development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	IEA Inferred from Electronic Annotation more info
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphoid progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in lymphoid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lymphoid progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in mammary gland formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland formation	ISO Inferred from Sequence Orthology more info
involved_in membranous septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in membranous septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mesoderm development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mesodermal cell fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesodermal cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephros development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in muscular septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerular mesangial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerular mesangial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glomerulus development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerulus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immature T cell proliferation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell proliferation involved in ureter development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mesenchymal cell proliferation involved in ureter development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell proliferation involved in ureter development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of metanephric S-shaped body morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of metanephric S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metanephric S-shaped body morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of metanephric comma-shaped body morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of metanephric comma-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metanephric comma-shaped body morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of prostatic bud formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of prostatic bud formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of striated muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thymocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nephric duct formation	IEA Inferred from Electronic Annotation more info
involved_in nephric duct formation	ISO Inferred from Sequence Orthology more info
involved_in nephric duct formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neuron fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ induction	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericyte cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pericyte cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal arch artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pituitary gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in lung morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle fiber development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesenchymal stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of odontoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of primary miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of primary miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect positive regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in prostatic bud formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of prostatic bud formation	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of branching involved in prostate gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of mesodermal cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
involved_in regulation of odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in renal system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal system process	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in secondary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in secondary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in secondary heart field specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in specification of animal organ position	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within specification of animal organ position	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info
involved_in telencephalon regionalization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telencephalon regionalization	ISO Inferred from Sequence Orthology more info
involved_in tendon cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in tendon cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in tendon cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tongue morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within trachea development	ISO Inferred from Sequence Orthology more info
involved_in trachea formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trachea formation	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell development	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureter morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ureter morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein 4

Names: BMP-2B; BMP-4; bone morphogenetic protein 2B

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012827.2 → NP_036959.2 bone morphogenetic protein 4 precursor

See identical proteins and their annotated locations for NP_036959.2

Status: PROVISIONAL

Source sequence(s)

BC078901

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

22098191..22113145 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251751.4 → XP_006251813.1 bone morphogenetic protein 4 isoform X1

See identical proteins and their annotated locations for XP_006251813.1

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide
XM_006251748.5 → XP_006251810.1 bone morphogenetic protein 4 isoform X1

See identical proteins and their annotated locations for XP_006251810.1

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide
XM_063273995.1 → XP_063130065.1 bone morphogenetic protein 4 isoform X2
XM_039093006.1 → XP_038948934.1 bone morphogenetic protein 4 isoform X1

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide
XM_006251749.4 → XP_006251811.1 bone morphogenetic protein 4 isoform X1

See identical proteins and their annotated locations for XP_006251811.1

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide
XM_006251746.5 → XP_006251808.1 bone morphogenetic protein 4 isoform X1

See identical proteins and their annotated locations for XP_006251808.1

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Related

ENSRNOP00000012957.5

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide
XM_006251747.5 → XP_006251809.1 bone morphogenetic protein 4 isoform X1

See identical proteins and their annotated locations for XP_006251809.1

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide
XM_008770501.3 → XP_008768723.1 bone morphogenetic protein 4 isoform X1

See identical proteins and their annotated locations for XP_008768723.1

UniProtKB/TrEMBL

F7FF39, Q6AYU9, Q811S3

Conserved Domains (2) summary

cd19391
Location:302 → 408

TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide