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Syn1 synapsin I [ Rattus norvegicus (Norway rat) ]

Gene ID: 24949, updated on 13-Apr-2024

Summary

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Official Symbol
Syn1provided by RGD
Official Full Name
synapsin Iprovided by RGD
Primary source
RGD:3797
See related
Ensembl:ENSRNOG00000010365 AllianceGenome:RGD:3797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium-dependent protein binding activity. Involved in neuron development and synapse organization. Located in several cellular components, including dendrite; presynaptic active zone; and synaptic vesicle. Is anchored component of synaptic vesicle membrane. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 151.4), Spleen (RPKM 21.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3725745..3780940)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1172208..1227400)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1321315..1379202)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ETS transcription factor ELK1 Neighboring gene complement factor properdin Neighboring gene 60S ribosomal protein L12-like Neighboring gene TIMP metallopeptidase inhibitor 1 Neighboring gene A-Raf proto-oncogene, serine/threonine kinase Neighboring gene uncharacterized LOC134484040 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ribosomal protein L22 like 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release. Yang HJ, et al. J Neurosci, 2021 Mar 31. PMID 33632727, Free PMC Article
  2. Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells. Cifre M, et al. Mol Neurodegener, 2018 Mar 22. PMID 29566703, Free PMC Article
  3. Natural lecithin promotes neural network complexity and activity. Latifi S, et al. Sci Rep, 2016 May 27. PMID 27228907, Free PMC Article
  4. SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation. Tang LT, et al. Nat Commun, 2015 Jul 15. PMID 26173895, Free PMC Article
  5. Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter. Matsuzaki Y, et al. J Neurosci Methods, 2014 Feb 15. PMID 24361760

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.
    Title: Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.
  2. The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.
    Title: The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.
  3. MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
    Title: MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
  4. The miR1345p/Foxp2/Syn1 axis was found to contribute to cognitive impairment in a chronic ischemiainduced early VD model, which may enable the development of new therapeutic strategies for the prevention and treatment of VD.
    Title: miR‑134‑5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model.
  5. Study shows that neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion.
    Title: Neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion.
  6. The synapsin 1 in the insular cortex as a part of pathophysiological process that determines predisposition of Krushinsky-Molodkina rats to audiogenic seizures.
    Title: The expression and distribution of seizure-related and synaptic proteins in the insular cortex of rats genetically prone to audiogenic seizures.
  7. SUMOylation of synapsin Ia (SynIa) at K687 is necessary for SynIa function. Replacement of endogenous SynIa with a non-SUMOylatable mutant decreases the size of the releasable vesicle pool and impairs stimulated SV exocytosis.
    Title: SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.
  8. Report behavioral testing-related changes in the expression of synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats.
    Title: Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats.
  9. Results suggest a mechanism of A2aR modulation of neurotransmitter release in cultured cells from medulla oblongata and suggest that protein kinase A mediates this modulation of neurotransmitter release via synapsin I phosphorylation
    Title: Protein kinase A mediates adenosine A2a receptor modulation of neurotransmitter release via synapsin I phosphorylation in cultured cells from medulla oblongata.
  10. rSynI(1.0)-minCMV drives robust and neuron-specific transgene expression throughout the CNS and is therefore useful for viral vector-mediated neuron-specific gene delivery and generation of neuron-specific transgenic animals.
    Title: Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neuron development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in extrinsic component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton HDA PubMed 

General protein information

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Preferred Names
synapsin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110782.2 → NP_001104252.1  synapsin-1 isoform b

    See identical proteins and their annotated locations for NP_001104252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1, which results in a frame-shift, and a shorter isoform (b) with a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BG378858, CO401107, FQ084192, JAXUCZ010000021, M27924
    UniProtKB/TrEMBL
    A6JZR0
    Conserved Domains (3) summary
    pfam02078
    Location:115 → 212
    Synapsin; Synapsin, N-terminal domain
    pfam10581
    Location:1 → 27
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:214 → 416
    ATP-grasp_4; ATP-grasp domain

  2. NM_019133.2 → NP_062006.1  synapsin-1 isoform a

    See identical proteins and their annotated locations for NP_062006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BG378858, CO401107, FQ084192, JAXUCZ010000021, M27812
    UniProtKB/Swiss-Prot
    P09951, Q9WUX7
    UniProtKB/TrEMBL
    A6JZQ9
    Related
    ENSRNOP00000014250.5, ENSRNOT00000014250.7
    Conserved Domains (3) summary
    pfam02078
    Location:115 → 212
    Synapsin; Synapsin, N-terminal domain
    pfam10581
    Location:1 → 27
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:214 → 416
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    3725745..3780940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09951.3 GenPept UniProtKB/Swiss-Prot:P09951

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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