Wnt3 Wnt family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wnt3provided by RGD
Official Full Name: Wnt family member 3provided by RGD
Primary source: RGD:3972
See related: Ensembl:ENSRNOG00000003845 AllianceGenome:RGD:3972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: INT4
Summary: Predicted to enable cytokine activity; frizzled binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; limb bud formation; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within several processes, including axis specification; embryonic morphogenesis; and generation of neurons. Located in cytoplasm. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 11.7), Testes (RPKM 3.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (89180224..89224195)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (88680198..88724170)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (91830709..91874907)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wingless ligands and beta-catenin expression in the rat endometrium: The role of Wnt3 and Wnt7a/beta-catenin pathway at the embryo-uterine interface.
Title: Wingless ligands and beta-catenin expression in the rat endometrium: The role of Wnt3 and Wnt7a/beta-catenin pathway at the embryo-uterine interface.
HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling Pathways.
Title: HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/β-Catenin and BMP2 Signaling Pathways.
GAT1 inhibitor administration also hindered Wnt3-induced neurogenesis.
Title: Diabetes Impairs Wnt3 Protein-induced Neurogenesis in Olfactory Bulbs via Glutamate Transporter 1 Inhibition.
Growing evidence suggests that Wnt/beta-catenin signaling plays a central role in maintaining the intestinal stem-cell niche and in regulating proliferation and differentiation of stem cells within the intestinal epithelium.
Title: Wnt/β-catenin signaling cascade down-regulation following massive small bowel resection in a rat.
In an organoid culture assay, Wnt and fibroblast growth factor signaling simultaneously induced elongation and budding of kidney ureteric buds through Arl4c expression.
Title: A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures.
Our data support the hypothesis that proximate Wnt signalling is rapidly activated by amphetamine in the adult rat nucleus accumbens.
Title: Amphetamine stimulates Wnt3 increases in rat nucleus accumbens.
We propose that hyperbaric oxygen treatment promote stem cells to proliferate, which is correlated with Wnt-3 protein.
Title: Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy.
Thus, Wnt-3a overexpression is associated with an increase in Cx43 expression and altered migratory and proliferative activity in H9c2 cells. Cx43 might be one of the downstream target genes regulated by Wnt-3a
Title: Increased connexin 43 expression improves the migratory and proliferative ability of H9c2 cells by Wnt-3a overexpression.
Wnt-3a overcame toxic effects induced by Abeta in hippocampal neurons, including a neuronal impairment on cell survival, an increase in glycogen synthase kinase-3beta (GSK-3beta) and tau phosphorylation.
Title: Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

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General gene information

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Markers

Wnt3 (e-PCR), detects polymorphism
- UniSTS:526099

M32502 (e-PCR)
- UniSTS:180344

Wnt3 (e-PCR), detects polymorphism
- UniSTS:144777

Wnt3 (e-PCR), detects polymorphism
- UniSTS:516492

GDB:196138 (e-PCR)
- UniSTS:155819

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Spemann organizer formation at the anterior end of the primitive streak	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamete generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within head morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in limb bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in midbrain dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of collateral sprouting in absence of injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell growth	TAS Traceable Author Statement more info	PubMed
involved_in regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proto-oncogene Wnt-3

Names: Wingless-type MMTV integration site 3, homolog; wingless-related MMTV integration site 3; wingless-type MMTV integration site family, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105715.2 → NP_001099185.1 proto-oncogene Wnt-3 precursor

See identical proteins and their annotated locations for NP_001099185.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HJT1, D3ZCR1

Related

ENSRNOP00000005176.4, ENSRNOT00000005176.6

Conserved Domains (1) summary

cd19335
Location:42 → 355

Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

89180224..89224195

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597028.3 → XP_017452517.1 proto-oncogene Wnt-3 isoform X1

UniProtKB/TrEMBL

A0A8I6AN69

Related

ENSRNOP00000097138.1

Conserved Domains (1) summary

cd19335
Location:119 → 367

Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins