Ednra endothelin receptor type A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24326, updated on 1-Apr-2024

Summary

Symbol: Ednraprovided by RGD
Full Name: endothelin receptor type Aprovided by RGD
Primary source: RGD:2535
See related: Ensembl:ENSRNOG00000012721 AllianceGenome:RGD:2535
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eta; ET-A; ET-AR; Endor; RGD1559432
Summary: Enables endothelin receptor activity. Involved in several processes, including cellular response to mechanical stimulus; glomerular filtration; and positive regulation of cytosolic calcium ion concentration. Located in T-tubule and nuclear membrane. Colocalizes with membrane raft. Used to study hypertension; myocardial infarction; portal hypertension; pulmonary emphysema; and pulmonary hypertension. Biomarker of several diseases, including hyperhomocysteinemia; impotence; obstructive sleep apnea; renal fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 125.0), Heart (RPKM 74.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (47137360..47207961)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (30233540..30303727)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (33928356..33991703)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis.
Title: Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis.
Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats.
Title: Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats.
CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats.
Title: CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats.
Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes.
Title: Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes.
Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1.
Title: Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1.
Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency.
Title: Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency.
In hypertension, endothelin type A receptor and colocalization with tyrosine hydroxylase are enhanced in the olfactory bulb.
Title: Role of endothelin receptor type A on catecholamine regulation in the olfactory bulb of DOCA-salt hypertensive rats: Hemodynamic implications.
ETRA antagonist restores podocyte foot process effacement as well as the aberrant expression of TLR-3, nuclear factor-kappaB (NF-kappaB), and CD80 in puromycin aminonucleoside-injured kidneys
Title: Antiproteinuric effect of an endothelin-1 receptor antagonist in puromycin aminonucleoside-induced nephrosis in rat.
These results demonstrated that ET-AR siRNA upregulates nitric oxide production via NOS enzymes mainly through the PI3K/Akt pathway.
Title: Downregulation of endothelin A receptor (ETaR) ameliorates renal ischemia reperfusion injury by increasing nitric oxide production.
Heterologous expression of the endothelin receptor type A (ETR subtype ETA) did not affect cAMP levels in the nucleus and cytoplasm compartment
Title: Receptor- and cellular compartment-specific activation of the cAMP/PKA pathway by α(1)-adrenergic and ETA endothelin receptors.

Submit: New GeneRIF Correction See all GeneRIFs (125)

General gene information

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Markers

RH127903 (e-PCR)
- UniSTS:211213

RH141089 (e-PCR)
- UniSTS:223087

Ednra (e-PCR), detects polymorphism
- UniSTS:142965

D19Mco2 (e-PCR)
- UniSTS:240088

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endothelin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables endothelin receptor activity	IEA Inferred from Electronic Annotation more info
enables endothelin receptor activity	ISO Inferred from Sequence Orthology more info
enables endothelin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in aorta development	IEA Inferred from Electronic Annotation more info
involved_in aorta development	ISO Inferred from Sequence Orthology more info
involved_in artery smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in atrial cardiac muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in atrial cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in axon extension	IEA Inferred from Electronic Annotation more info
involved_in axon extension	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis involved in innervation	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis involved in innervation	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac chamber formation	IEA Inferred from Electronic Annotation more info
involved_in cardiac chamber formation	ISO Inferred from Sequence Orthology more info
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to human chorionic gonadotropin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to human chorionic gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to luteinizing hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to luteinizing hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to organic substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in developmental pigmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic heart tube development	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway involved in heart process	IEA Inferred from Electronic Annotation more info
involved_in endothelin receptor signaling pathway involved in heart process	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in face development	IEA Inferred from Electronic Annotation more info
involved_in face development	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in glomerular endothelium development	IEA Inferred from Electronic Annotation more info
involved_in glomerular endothelium development	ISO Inferred from Sequence Orthology more info
involved_in glomerular filtration	IEA Inferred from Electronic Annotation more info
involved_in glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in glomerulus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within head development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart process	ISO Inferred from Sequence Orthology more info
involved_in heparin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in heparin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in histamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in left ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in left ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in parturition	IEP Inferred from Expression Pattern more info	PubMed
involved_in meiotic cell cycle process involved in oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in middle ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in noradrenergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in noradrenergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal arch artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in podocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in podocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase A signaling	IEA Inferred from Electronic Annotation more info
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell leading edge	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to cell leading edge	ISO Inferred from Sequence Orthology more info
involved_in renal albumin absorption	IEA Inferred from Electronic Annotation more info
involved_in renal albumin absorption	ISO Inferred from Sequence Orthology more info
involved_in renal sodium ion absorption	IEA Inferred from Electronic Annotation more info
involved_in renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	ISO Inferred from Sequence Orthology more info
involved_in response to acetylcholine	IEA Inferred from Electronic Annotation more info
involved_in response to acetylcholine	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sympathetic nervous system development	IEA Inferred from Electronic Annotation more info
involved_in sympathetic nervous system development	ISO Inferred from Sequence Orthology more info
involved_in sympathetic neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in sympathetic neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in vascular associated smooth muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endothelin-1 receptor

Names: endothelin A receptor; endothelin-1 receptor-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012550.2 → NP_036682.1 endothelin-1 receptor precursor

See identical proteins and their annotated locations for NP_036682.1

Status: VALIDATED

Source sequence(s)

CB798671, DQ832324, JAXUCZ010000019

UniProtKB/Swiss-Prot

P26684

UniProtKB/TrEMBL

A0A0G2JSX5

Related

ENSRNOP00000054967.2, ENSRNOT00000058162.4

Conserved Domains (1) summary

pfam00001
Location:97 → 367

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

47137360..47207961

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097468.2 → XP_038953396.1 endothelin-1 receptor isoform X1

UniProtKB/Swiss-Prot

P26684

UniProtKB/TrEMBL

A1Y2B8

Conserved Domains (1) summary

cd15975
Location:81 → 380

7tmA_ET-AR; endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors