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Srsf7 serine and arginine-rich splicing factor 7 [ Mus musculus (house mouse) ]

Gene ID: 225027, updated on 7-Apr-2024

Summary

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Official Symbol
Srsf7provided by MGI
Official Full Name
serine and arginine-rich splicing factor 7provided by MGI
Primary source
MGI:MGI:1926232
See related
Ensembl:ENSMUSG00000024097 AllianceGenome:MGI:1926232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9G8; 35kDa; NX-96; Sfrs7; 9430065L19Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple protein-coding and non-protein-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 98.8), CNS E14 (RPKM 77.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E3; 17 50.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80507509..80514734, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80200080..80207369, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:80530153-80530306 Neighboring gene galactose mutarotase Neighboring gene STARR-seq mESC enhancer starr_43303 Neighboring gene STARR-positive B cell enhancer ABC_E5630 Neighboring gene microRNA 12189 Neighboring gene STARR-positive B cell enhancer ABC_E3216 Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E7559 Neighboring gene STARR-positive B cell enhancer ABC_E5631 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene STARR-positive B cell enhancer ABC_E3217 Neighboring gene STARR-positive B cell enhancer ABC_E5632 Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene DExH-box helicase 57

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice. Kadota Y, et al. iScience, 2020 Mar 27. PMID 32146325, Free PMC Article
  2. SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly. Königs V, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32123389, Free PMC Article
  3. SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Schwich OD, et al. Genome Biol, 2021 Mar 11. PMID 33706811, Free PMC Article
  4. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10. Gu J, et al. FEBS Lett, 2012 Jul 30. PMID 22677170
  5. Screening for genes up-regulated in 5/6 nephrectomized mouse kidney. Zhang H, et al. Kidney Int, 1999 Aug. PMID 10432394

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
    Title: SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
  2. SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly.
    Title: SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly.
  3. 9G8 binds to an element in exon 3 and strongly enhances the excision of GnRH intron A in the presence of minimal amount of other nuclear components
    Title: Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38287

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 7
Names
splicing factor, arginine/serine-rich 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195485.1 → NP_001182414.1  serine/arginine-rich splicing factor 7 isoform 2

    See identical proteins and their annotated locations for NP_001182414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK045884, AK082848, AK137795, BX519093
    Consensus CDS
    CCDS89160.1
    UniProtKB/Swiss-Prot
    Q8BL97, Q8BMC6, Q8BUR2, Q8R2N4, Q8R3E9, Q91YS1
    UniProtKB/TrEMBL
    A0A3Q4L393
    Related
    ENSMUSP00000157383.2, ENSMUST00000235069.2
    Conserved Domains (1) summary
    cd12646
    Location:12 → 88
    RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

  2. NM_001195486.1 → NP_001182415.1  serine/arginine-rich splicing factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001182415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK045884, AK137795, BX519093, BY740981
    UniProtKB/Swiss-Prot
    Q8BL97
    UniProtKB/TrEMBL
    Q3THA6
    Conserved Domains (1) summary
    cd12646
    Location:12 → 88
    RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

  3. NM_001195487.1 → NP_001182416.1  serine/arginine-rich splicing factor 7 isoform 4

    See identical proteins and their annotated locations for NP_001182416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI550251, AK045884, AK137795, BX519093
    UniProtKB/Swiss-Prot
    Q8BL97, Q8BMC6, Q8BUR2, Q8R2N4, Q8R3E9, Q91YS1
    Conserved Domains (1) summary
    cd12646
    Location:12 → 88
    RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

  4. NM_001360435.1 → NP_001347364.1  serine/arginine-rich splicing factor 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC132910, AC140361
    Conserved Domains (1) summary
    cd12646
    Location:12 → 88
    RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

  5. NM_001404106.1 → NP_001391035.1  serine/arginine-rich splicing factor 7 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice junction at the 3' end of an exon and lacks an exon in the 3' coding region, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
    Source sequence(s)
    AC132910, AC140361
    UniProtKB/TrEMBL
    A0A3Q4L335
    Related
    ENSMUSP00000157263.2, ENSMUST00000234696.2

  6. NM_146083.2 → NP_666195.1  serine/arginine-rich splicing factor 7 isoform 1

    See identical proteins and their annotated locations for NP_666195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK045884, AK137795, BX519093
    Consensus CDS
    CCDS28988.1
    UniProtKB/Swiss-Prot
    Q8BL97, Q8BMC6, Q8BUR2, Q8R2N4, Q8R3E9, Q91YS1
    UniProtKB/TrEMBL
    Q3THA6
    Related
    ENSMUSP00000070983.10, ENSMUST00000063417.11
    Conserved Domains (1) summary
    cd12646
    Location:12 → 88
    RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

RNA

  1. NR_036615.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon with an in-frame stop codon. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so this variant is not thought to be protein-coding.
    Source sequence(s)
    AC132910, AK034952, AK045884, BX519093

  2. NR_175814.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC132910, AC140361

  3. NR_175815.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC132910, AC140361

  4. NR_175816.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC132910, AC140361

  5. NR_175817.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC132910, AC140361

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80507509..80514734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL97.1 GenPept UniProtKB/Swiss-Prot:Q8BL97

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