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Skp1 S-phase kinase-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21402, updated on 25-Apr-2024

Summary

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Official Symbol
Skp1provided by MGI
Official Full Name
S-phase kinase-associated protein 1provided by MGI
Primary source
MGI:MGI:103575
See related
Ensembl:ENSMUSG00000036309 AllianceGenome:MGI:103575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OCP2; p19A; 15kDa; EMC19; Skp1a; OCP-II; Tceb1l; p19Skp1; 2610043E24Rik; 2610206H23Rik
Summary
Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Located in centrosome and cytosol. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; notochord; and sensory organ. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 68.9), CNS E11.5 (RPKM 64.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 31.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52121349..52137685)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52230522..52246858)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12206 Neighboring gene STARR-seq mESC enhancer starr_29443 Neighboring gene STARR-seq mESC enhancer starr_29444 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52045093-52045276 Neighboring gene STARR-positive B cell enhancer ABC_E8401 Neighboring gene olfactory receptor family 2 subfamily Y member 6 Neighboring gene transcription factor 7, T cell specific Neighboring gene STARR-seq mESC enhancer starr_29449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52096181-52096290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52097872-52098055 Neighboring gene STARR-seq mESC enhancer starr_29452 Neighboring gene STARR-seq mESC enhancer starr_29453 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52132162-52132271 Neighboring gene predicted gene, 30217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52152988-52153277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52154886-52154995 Neighboring gene STARR-positive B cell enhancer ABC_E11479 Neighboring gene STARR-seq mESC enhancer starr_29458 Neighboring gene voltage-dependent anion channel 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease. Mandel SA, et al. Parkinsonism Relat Disord, 2012 Jan. PMID 22166427
  2. A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A. Fishman-Jacob T, et al. J Biol Chem, 2009 Nov 20. PMID 19748892, Free PMC Article
  3. miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation. Li R, et al. Arch Biochem Biophys, 2023 Jan 15. PMID 36592647
  4. An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2. Yamagishi Y, et al. Cell Rep, 2016 Oct 11. PMID 27732853, Free PMC Article
  5. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Freed E, et al. Genes Dev, 1999 Sep 1. PMID 10485847, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-582-5p targets Skp1 and regulates NF-kappaB signaling-mediated inflammation.
    Title: miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation.
  2. Loss of SKP1 prior to meiosis leads to aberrant localization of DSB repair proteins and a failure in synapsis initiation in meiosis of both males and females as well as a defect in sister chromatid cohesion. FBXO47 interacts with SKP1 and HORMAD1 and targets HORMAD1 for polyubiquitination and degradation in HEK293T cells.
    Title: SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.
  3. SKP1 localizes to synapsed chromosome axes and evicts HORMAD proteins from these regions in meiotic spermatocytes. SKP1 maintains synapsis in meiosis of both sexes. SKP1-deficient spermatocytes display premature desynapsis, precocious pachytene exit, loss of PLK1 and BUB1 at centromeres. SKP1-deficient spermatocytes show sharply reduced MPF activity and fail to enter MI despite treatment with okadaic acid.
    Title: SKP1 drives the prophase I to metaphase I transition during male meiosis.
  4. Consistent with Skp1a functioning through regulation of Nmnat2, Skp1a knockdown fails to protect axons from Nmnat2 knockdown.
    Title: An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2.
  5. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
    Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
  6. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
    Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
  7. In this review, deficiency of SKP1A in SN4741 cells closely recapitulates cardinal features of the dopamine (DA) neuron pathology of human Parkinson's disease, such as decreased expression of DA phenotypic markers and cell cycle aberrations.
    Title: Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease.
  8. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner
    Title: APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1.
  9. Skp1 is a potential modifier in sporadic Parkinson disease neurodegeneration
    Title: A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables F-box domain binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin ligase complex scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein monoubiquitination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul7-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul7-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
S-phase kinase-associated protein 1
Names
S-phase kinase-associated protein 1A
cyclin-A/CDK2-associated protein p19
NP_035673.3
XP_006532849.1
XP_036012398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011543.4 → NP_035673.3  S-phase kinase-associated protein 1

    See identical proteins and their annotated locations for NP_035673.3

    Status: VALIDATED

    Source sequence(s)
    AK012498, AK078330, BU841654
    Consensus CDS
    CCDS24669.1
    UniProtKB/Swiss-Prot
    Q8C5H6, Q9WTX5
    UniProtKB/TrEMBL
    Q3TL58, Q5SUR3
    Related
    ENSMUSP00000038744.6, ENSMUST00000037324.12
    Conserved Domains (2) summary
    cd18322
    Location:3 → 127
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
    pfam01466
    Location:113 → 160
    Skp1; Skp1 family, dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    52121349..52137685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532786.2 → XP_006532849.1  S-phase kinase-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006532849.1

    UniProtKB/Swiss-Prot
    Q8C5H6, Q9WTX5
    UniProtKB/TrEMBL
    Q3TL58, Q5SUR3
    Conserved Domains (2) summary
    cd18322
    Location:3 → 127
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
    pfam01466
    Location:113 → 160
    Skp1; Skp1 family, dimerization domain

  2. XM_036156505.1 → XP_036012398.1  S-phase kinase-associated protein 1 isoform X2

    Conserved Domains (2) summary
    cd18322
    Location:2 → 92
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
    pfam01466
    Location:78 → 125
    Skp1; Skp1 family, dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTX5.3 GenPept UniProtKB/Swiss-Prot:Q9WTX5

Gene LinkOut

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