Y71H2AM.20 Serine/threonine-protein phosphatase 2A activator;peptidylprolyl isomerase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: Y71H2AM.20
Gene description: Serine/threonine-protein phosphatase 2A activator;peptidylprolyl isomerase
Primary source: WormBase:WBGene00022185
Locus tag: CELE_Y71H2AM.20
See related: AllianceGenome:WB:WBGene00022185
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity and protein tyrosine phosphatase activator activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (2782733..2785948, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y71H2_388.f (e-PCR)
- UniSTS:323798

Y71H2_388.c (e-PCR)
- UniSTS:323314

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine/threonine-protein phosphatase 2A activator;peptidylprolyl isomerase

NP_001360129.1

Confirmed by transcript evidence

NP_497617.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

2782733..2785948 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065216.7 → NP_497617.1 Serine/threonine-protein phosphatase 2A activator [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497617.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9BL35

Conserved Domains (1) summary

pfam03095
Location:9 → 303

PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
NM_001373862.2 → NP_001360129.1 peptidylprolyl isomerase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0S3

Conserved Domains (1) summary

cl03888
Location:1 → 24

PTPA; Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine ...