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ads-1 Alkyldihydroxyacetonephosphate synthase [ Caenorhabditis elegans ]

Gene ID: 175192, updated on 3-Mar-2024

Summary

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Gene symbol
ads-1
Gene description
Alkyldihydroxyacetonephosphate synthase
Primary source
WormBase:WBGene00000081
Locus tag
CELE_Y50D7A.7
See related
AllianceGenome:WB:WBGene00000081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable FAD binding activity and alkylglycerone-phosphate synthase activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to be located in peroxisome. Is expressed in intestine. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata and rhizomelic chondrodysplasia punctata type 3. Orthologous to human AGPS (alkylglycerone phosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (295654..298556, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transcriptional regulatory protein Neighboring gene 30S ribosomal protein S15;Peptidase metallopeptidase domain-containing protein Neighboring gene DUF295 domain-containing protein;F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ADF-H domain-containing protein Neighboring gene PDZ domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel DNA repair alkyltransferase from Caenorhabditis elegans. Kanugula S, et al. Environ Mol Mutagen, 2001. PMID 11746760
  2. RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders. Petriv OI, et al. Physiol Genomics, 2002 Aug 14. PMID 12181365
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alkylglycerone-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkylglycerone-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables alkylglycerone-phosphate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ether lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ether lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Alkyldihydroxyacetonephosphate synthase
NP_497185.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    295654..298556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064784.11 → NP_497185.1  Alkyldihydroxyacetonephosphate synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497185.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45218
    Conserved Domains (3) summary
    COG0277
    Location:92 → 581
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:135 → 276
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:313 → 581
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45218.1

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