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gpdh-3 putative glycerol-3-phosphate dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 172509, updated on 25-Apr-2024

Summary

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Gene symbol
gpdh-3
Gene description
putative glycerol-3-phosphate dehydrogenase, mitochondrial
Primary source
WormBase:WBGene00012031
Locus tag
CELE_T25G3.4
See related
AllianceGenome:WB:WBGene00012031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity. Predicted to be involved in glycerol catabolic process and glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (7564584..7567719)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Chitin synthase chs-1 Neighboring gene 60S ribosomal export protein NMD3 Neighboring gene ncRNA Neighboring gene alpha-1,2-Mannosidase Neighboring gene ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative glycerol-3-phosphate dehydrogenase, mitochondrial
NP_492115.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7564584..7567719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059714.7 → NP_492115.1  putative glycerol-3-phosphate dehydrogenase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90795, Q22793
    Conserved Domains (4) summary
    PLN02464
    Location:46 → 602
    PLN02464; glycerol-3-phosphate dehydrogenase
    cd00051
    Location:628 → 685
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:629 → 689
    EF-hand_7; EF-hand domain pair
    pfam16901
    Location:464 → 590
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90795.2

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