U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atp5pb ATP synthase peripheral stalk-membrane subunit b [ Rattus norvegicus (Norway rat) ]

Gene ID: 171375, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Symbol
Atp5pbprovided by RGD
Full Name
ATP synthase peripheral stalk-membrane subunit bprovided by RGD
Primary source
RGD:620041
See related
Ensembl:ENSRNOG00000064742 AllianceGenome:RGD:620041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5f1
Summary
Contributes to ATP hydrolysis activity. Involved in ATP metabolic process and cellular response to hypoxia. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5PB (ATP synthase peripheral stalk-membrane subunit b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 5793.3), Muscle (RPKM 4106.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196112459..196123737, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193424138..193435418, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208566385..208577147, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene adenosine A3 receptor Neighboring gene similar to human chromosome 1 open reading frame 162 Neighboring gene WD repeat domain 77 Neighboring gene uncharacterized LOC134485667

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma. Lee CF, et al. World J Gastroenterol, 2008 Oct 21. PMID 18932288, Free PMC Article
  2. cDNA cloning and sequencing for the import precursor of subunit B in H(+)-ATP synthase from rat mitochondria. Tsurumi C, et al. Biochem Biophys Res Commun, 1990 May 31. PMID 2140936
  3. iTRAQ-Based Proteomic Analysis Reveals Recovery of Impaired Mitochondrial Function in Ischemic Myocardium by Shenmai Formula. Wang Y, et al. J Proteome Res, 2018 Feb 2. PMID 29300489
  4. Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma. Brüggemann M, et al. Transl Oncol, 2017 Aug. PMID 28672194, Free PMC Article
  5. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, et al. J Biol Chem, 2000 Oct 20. PMID 10887193

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ATP synthase F(0) complex subunit B1, mitochondrial
Names
ATP synthase subunit b, mitochondrial
ATP synthase subunit b, mitochondrial-like
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATPase subunit b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134365.2 → NP_599192.1  ATP synthase F(0) complex subunit B1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_599192.1

    Status: VALIDATED

    Source sequence(s)
    BC063808, CK845764, JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P19511
    UniProtKB/TrEMBL
    A0A8L2QWG8, A6HUP1
    Related
    ENSRNOP00000021920.4, ENSRNOT00000021920.7
    Conserved Domains (1) summary
    pfam05405
    Location:83 → 244
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    196112459..196123737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101623.2 → XP_038957551.1  ATP synthase F(0) complex subunit B1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2QWG8
    Related
    ENSRNOP00000065147.2
    Conserved Domains (1) summary
    pfam05405
    Location:62 → 223
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19511.1 GenPept UniProtKB/Swiss-Prot:P19511

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous