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Atp5mc2 ATP synthase membrane subunit c locus 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171082, updated on 2-May-2024

Summary

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Official Symbol
Atp5mc2provided by RGD
Official Full Name
ATP synthase membrane subunit c locus 2provided by RGD
Primary source
RGD:620051
See related
Ensembl:ENSRNOG00000015320 AllianceGenome:RGD:620051
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5g2
Summary
Enables ligand-gated channel activity. Involved in pore complex assembly; response to 3,3',5-triiodo-L-thyronine; and response to ethanol. Part of cation channel complex. Human ortholog(s) of this gene implicated in renal cell carcinoma and urinary bladder cancer. Orthologous to human ATP5MC2 (ATP synthase membrane subunit c locus 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1941.0), Muscle (RPKM 1596.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135669847..135680839, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133791341..133799713, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144264207..144272578, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene activating transcription factor 7 Neighboring gene uncharacterized LOC120093744 Neighboring gene calcium binding and coiled coil domain 1 Neighboring gene chondrogenesis-associated transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: Preliminary findings. Campo G, et al. Int J Cardiol, 2016 Oct 15. PMID 27441480
  2. Tumor suppressor RIZ1 in obesity and the PI3K/AKT/mTOR pathway. Xie X, et al. Obesity (Silver Spring), 2016 Feb. PMID 26709097
  3. Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma. Brüggemann M, et al. Transl Oncol, 2017 Aug. PMID 28672194, Free PMC Article
  4. Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma. Morris MR, et al. Oncogene, 2011 Mar 24. PMID 21132003
  5. Batten disease and the control of the Fo subunit c pore by cGMP and calcium. McGeoch JE, et al. Eur J Paediatr Neurol, 2001. PMID 11588987

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ligand-gated channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pore complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to 3,3',5-triiodo-L-thyronine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase F(0) complex subunit C2, mitochondrial
Names
ATP synthase lipid-binding protein, mitochondrial
ATP synthase proteolipid P2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATPase protein 9
ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133556.2 → NP_598240.1  ATP synthase F(0) complex subunit C2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_598240.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128726
    UniProtKB/Swiss-Prot
    A2VCW6, Q06646
    UniProtKB/TrEMBL
    A0A8I6AM76, A6KCX5
    Related
    ENSRNOP00000020675.3, ENSRNOT00000020676.7
    Conserved Domains (1) summary
    MTH00222
    Location:67 → 141
    ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135669847..135680839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262948.1 → XP_063119018.1  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    A2VCW6, Q06646
    UniProtKB/TrEMBL
    A6KCX5

  2. XM_039078345.2 → XP_038934273.1  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    A2VCW6, Q06646
    UniProtKB/TrEMBL
    A0A8I6AM76, A6KCX5
    Conserved Domains (1) summary
    MTH00222
    Location:67 → 141
    ATP9; ATP synthase F0 subunit 9; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06646.1 GenPept UniProtKB/Swiss-Prot:Q06646

Gene LinkOut

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