Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp26a1provided by RGD
Official Full Name: cytochrome P450, family 26, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:620161
See related: Ensembl:ENSRNOG00000016750 AllianceGenome:RGD:620161
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp26
Summary: Predicted to enable monooxygenase activity and retinoic acid binding activity. Involved in kidney development; response to retinoic acid; and response to vitamin A. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 39.4), Uterus (RPKM 17.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (244883822..244887657)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (235471368..235475204)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (256382861..256386729)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cyp26a1-regulated Th17 cells are dependent on all trans retinoic acid signalling, which is delivered through RARalpha in mouse peri-implantation.
Title: Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.
Cyp26a1 is spatiotemporally expressed in the uterus during embryo implantation and decidualization. Overexpression of Cyp26a1 attenuates the process of uterine stromal cell apoptosis, probably via down-regulating the expression of p53 and FasL
Title: Retinoic acid metabolizing enzyme CYP26A1 is implicated in rat embryo implantation.
the functioning of multiple RAREs may account for the strong inducibility of CYP26A1 in liver, which, in turn, may be important physiologically for restoring retinoid homeostasis when the concentration of RA rises.
Title: Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liver.
Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. CYP26 mRNA expression is dynamically regulated in vivo by diet and RA in hepatic and extrahepatic tissues.
Title: Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo.
Cyp26a1 attenuates retinoic acid signaling in the prospective rostral spinal cord to limit the expression of hox genes and to determine the hindbrain-spinal cord boundary.
Title: Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish.

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General gene information

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Markers

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:516134

UniSTS:462985 (e-PCR)
- UniSTS:462985

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:462985

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:525747

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:275891

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:508365

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:519407

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans retinoic acid 18-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within neural crest cell development	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450, family 26, subfamily a, polypeptide 1

Names: cytochrome P450, 26, retinoic acid; retinoic acid hydrolase; retinoic acid hydroxylase

NP_569092.2

EC 1.14.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.