H3f3a H3.3 histone A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H3f3aprovided by MGI
Official Full Name: H3.3 histone Aprovided by MGI
Primary source: MGI:MGI:1097686
See related: Ensembl:ENSMUSG00000060743 AllianceGenome:MGI:1097686
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H3-3a; H3-3b; H3.3A; EyeLinc14
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015]
Expression: Broad expression in liver E14 (RPKM 493.6), CNS E14 (RPKM 457.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 84.46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (180630125..180641127, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (180802560..180813605, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A knockout-first model of H3f3a gene targeting leads to developmental lethality.
Title: A knockout-first model of H3f3a gene targeting leads to developmental lethality.
Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase.
Title: Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase.
Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation.
Title: Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation.
Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells.
Title: Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells.
An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.
Title: An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.
H3.3 impedes zygotic transcriptional program activated by Dux.
Title: H3.3 impedes zygotic transcriptional program activated by Dux.
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes.
Title: KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes.
The results demonstrate that Zfp296 is a component of heterochromatin that affects embryonic development by negatively regulating H3K9 methylation.
Title: Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.
Data (including data from studies using transgenic mice) suggest that H3f3a and H3f3b are required for (1) paternal chromatin remodeling, (2) development of preimplantation embryos, and (3) activation of paternal genome during embryogenesis.
Title: Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos.
Data suggest a role for H3 histone lysine 9 (H3K9) methylation in promoting DNA methylation, and indicate that DNA maintenance methylation in mammals is largely independent of H3K9 methylation.
Title: Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (1)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H3f3a (e-PCR), detects polymorphism
- UniSTS:265525

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

H3f3a (e-PCR), detects polymorphism
- UniSTS:525689

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

WI-6046 (e-PCR)
- UniSTS:73465

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of chromatin	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of chromosome condensation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pericentric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within subtelomeric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Barr body	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
part_of inner kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H3.3

Names: H3 histone, family 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.