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GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial [ Homo sapiens (human) ]

Gene ID: 150763, updated on 11-Apr-2024

Summary

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Official Symbol
GPAT2provided by HGNC
Official Full Name
glycerol-3-phosphate acyltransferase 2, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:27168
See related
Ensembl:ENSG00000186281 MIM:616431; AllianceGenome:HGNC:27168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT123
Summary
Enables glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in several processes, including glycerol-3-phosphate metabolic process; glycerolipid biosynthetic process; and piRNA biosynthetic process. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 7.1), spleen (RPKM 3.6) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
2q11.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96021946..96036265, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95919725..96542891, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96687694..96702013, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 210, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96675379-96676210 Neighboring gene fumarylacetoacetate hydrolase domain-containing protein 2B-like Neighboring gene fumarylacetoacetate hydrolase domain containing 2C, pseudogene Neighboring gene uncharacterized LOC105373494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96725007-96725917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96757989-96758504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96774519-96775506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11747 Neighboring gene adrenoceptor alpha 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line. Pellon-Maison M, et al. PLoS One, 2014. PMID 24967918, Free PMC Article
  2. Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity. Gimeno RE, et al. J Lipid Res, 2008 Oct. PMID 18658143
  3. Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2). Wang S, et al. Arch Biochem Biophys, 2007 Sep 15. PMID 17689486, Free PMC Article
  4. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. Shiromoto Y, et al. RNA, 2013 Jun. PMID 23611983, Free PMC Article
  5. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. Chen YQ, et al. J Biol Chem, 2008 Apr 11. PMID 18238778, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPAT2 as a cancer testis gene
    Title: Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycerol-3-phosphate O-acyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
glycerol-3-phosphate acyltransferase 2, mitochondrial
Names
1-acylglycerol-3-phosphate O-acyltransferase GPAT2
cancer/testis antigen 123
NP_001308454.1
NP_001308455.1
NP_001308456.1
NP_001308457.1
NP_001308458.1
NP_001308459.1
NP_001308460.1
NP_001376568.1
NP_997211.2
XP_016858913.1
XP_047299417.1
XP_047299418.1
XP_047299419.1
XP_047299420.1
XP_047299421.1
XP_047299422.1
XP_047299423.1
XP_047299424.1
XP_047299425.1
XP_047299426.1
XP_047299427.1
XP_047299428.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321525.2 → NP_001308454.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Consensus CDS
    CCDS92811.1
    UniProtKB/TrEMBL
    B4DNZ9
    Related
    ENST00000486463.5
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  2. NM_001321526.2 → NP_001308455.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Consensus CDS
    CCDS92811.1
    UniProtKB/TrEMBL
    B4DNZ9
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  3. NM_001321527.2 → NP_001308456.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Consensus CDS
    CCDS92811.1
    UniProtKB/TrEMBL
    B4DNZ9
    Related
    ENSP00000389395.2, ENST00000434632.6
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  4. NM_001321528.2 → NP_001308457.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  5. NM_001321529.2 → NP_001308458.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC013272
    UniProtKB/TrEMBL
    B4DNZ9
    Conserved Domains (1) summary
    cl17185
    Location:176 → 317
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  6. NM_001321530.2 → NP_001308459.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Consensus CDS
    CCDS82482.1
    UniProtKB/TrEMBL
    B4DNZ9, E9PE95
    Related
    ENSP00000393770.1, ENST00000453542.5
    Conserved Domains (1) summary
    cl17185
    Location:176 → 317
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  7. NM_001321531.2 → NP_001308460.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC013272, AK131194, BC068596
    Consensus CDS
    CCDS92810.1
    Related
    ENSP00000509192.1, ENST00000687910.1
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  8. NM_001389639.1 → NP_001376568.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  9. NM_207328.4 → NP_997211.2  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_997211.2

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Consensus CDS
    CCDS42714.1
    UniProtKB/Swiss-Prot
    Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4
    UniProtKB/TrEMBL
    B4DNZ9
    Related
    ENSP00000352547.4, ENST00000359548.8
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    96021946..96036265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443468.1 → XP_047299424.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4

  2. XM_047443464.1 → XP_047299420.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

  3. XM_047443466.1 → XP_047299422.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4

  4. XM_047443462.1 → XP_047299418.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

  5. XM_047443467.1 → XP_047299423.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4

  6. XM_017003424.2 → XP_016858913.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    B4DNZ9
    Conserved Domains (1) summary
    cd07993
    Location:176 → 388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  7. XM_047443463.1 → XP_047299419.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

  8. XM_047443465.1 → XP_047299421.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X2

  9. XM_047443461.1 → XP_047299417.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

    Related
    ENST00000484440.5

  10. XM_047443471.1 → XP_047299427.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X7

  11. XM_047443472.1 → XP_047299428.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X8

  12. XM_047443470.1 → XP_047299426.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X6

  13. XM_047443469.1 → XP_047299425.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X5

RNA

  1. XR_007069660.1 RNA Sequence

  2. XR_007069659.1 RNA Sequence

  3. XR_007069658.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791765.1 Reference GRCh38.p14 PATCHES

    Range
    55799..58170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    95919725..96542891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NUI2.2 GenPept UniProtKB/Swiss-Prot:Q6NUI2

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