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Gtf2h4 general transcription factor II H, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 14885, updated on 11-Apr-2024

Summary

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Official Symbol
Gtf2h4provided by MGI
Official Full Name
general transcription factor II H, polypeptide 4provided by MGI
Primary source
MGI:MGI:1338799
See related
Ensembl:ENSMUSG00000001524 AllianceGenome:MGI:1338799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p52; BTF2 p52
Summary
This gene encodes a subunit of the general transcription factor multiprotein complex that plays roles in basal transcription, DNA repair and cell cycle control. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in thymus adult (RPKM 68.7), limb E14.5 (RPKM 11.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.7 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35978624..35984607, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35667728..35673750, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene surfactant associated 2 Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E7529 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35808865-35809171 Neighboring gene STARR-positive B cell enhancer ABC_E7530 Neighboring gene STARR-seq mESC enhancer starr_42470 Neighboring gene discoidin domain receptor family, member 1 Neighboring gene STARR-seq mESC enhancer starr_42472 Neighboring gene predicted gene, 23864 Neighboring gene predicted gene 4577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional insights into the core-TFIIH from a comparative survey. Bedez F, et al. Genomics, 2013 Mar. PMID 23147676
  2. The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H2 complex: cloning and sequence polymorphism. Lanning D, et al. Immunogenetics, 1999 Jun. PMID 10380693
  3. TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Le May N, et al. Cell, 2004 Feb 20. PMID 14980221
  4. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
  5. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core TFIIH complex portion of holo TFIIH complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor IIH subunit 4
Names
TFIIH basal transcription factor complex p52 subunit
basic transcription factor 2 52 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413326.1 → NP_001400255.1  general transcription factor IIH subunit 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/Swiss-Prot
    O70422
    UniProtKB/TrEMBL
    Q542U3

  2. NM_001413327.1 → NP_001400256.1  general transcription factor IIH subunit 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/Swiss-Prot
    O70422
    UniProtKB/TrEMBL
    Q542U3
    Related
    ENSMUSP00000124335.2, ENSMUST00000160734.8

  3. NM_001413328.1 → NP_001400257.1  general transcription factor IIH subunit 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/Swiss-Prot
    O70422
    UniProtKB/TrEMBL
    Q542U3

  4. NM_001413330.1 → NP_001400259.1  general transcription factor IIH subunit 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR974483

  5. NM_001413331.1 → NP_001400260.1  general transcription factor IIH subunit 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974483

  6. NM_001413332.1 → NP_001400261.1  general transcription factor IIH subunit 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974483

  7. NM_001413333.1 → NP_001400262.1  general transcription factor IIH subunit 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974483

  8. NM_010364.5 → NP_034494.1  general transcription factor IIH subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_034494.1

    Status: VALIDATED

    Source sequence(s)
    CR974483
    Consensus CDS
    CCDS28702.1
    UniProtKB/Swiss-Prot
    O70422
    UniProtKB/TrEMBL
    Q3UEU9, Q542U3
    Related
    ENSMUSP00000001565.9, ENSMUST00000001565.15
    Conserved Domains (1) summary
    TIGR00625
    Location:19 → 461
    tfb2; Transcription factor tfb2

RNA

  1. NR_182136.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974483
    Related
    ENSMUST00000160752.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35978624..35984607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70422.1 GenPept UniProtKB/Swiss-Prot:O70422

Gene LinkOut

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