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Adgrg1 adhesion G protein-coupled receptor G1 [ Mus musculus (house mouse) ]

Gene ID: 14766, updated on 11-Apr-2024

Summary

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Official Symbol
Adgrg1provided by MGI
Official Full Name
adhesion G protein-coupled receptor G1provided by MGI
Primary source
MGI:MGI:1340051
See related
Ensembl:ENSMUSG00000031785 AllianceGenome:MGI:1340051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyt28; Gpr56; TM7LN4; TM7XN1
Summary
Enables several functions, including collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Involved in several processes, including negative regulation of neuron migration; positive regulation of Rho protein signal transduction; and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 93.7), ovary adult (RPKM 80.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C5; 8 47.12 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95701321..95740836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94974756..95014208)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene adhesion G protein-coupled receptor G5 Neighboring gene STARR-positive B cell enhancer ABC_E8258 Neighboring gene STARR-positive B cell enhancer ABC_E3795 Neighboring gene predicted gene, 30968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97500803-97501004 Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene dynein regulatory complex subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR56 S4 variant is required for microglia-mediated synaptic pruning. Li T, et al. Glia, 2023 Mar. PMID 36336959
  2. Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation. Sasaki SI, et al. Cancer Sci, 2021 Dec. PMID 34632664, Free PMC Article
  3. 57R2A, a newly established monoclonal antibody against mouse GPR56, marks long-term repopulating hematopoietic stem cells. Tokoro Y, et al. Exp Hematol, 2018 Mar. PMID 29225194
  4. Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Salzman GS, et al. Neuron, 2016 Sep 21. PMID 27657451, Free PMC Article
  5. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Rao TN, et al. Stem Cell Res, 2015 May. PMID 25840412, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in Glomerular Endothelial Cells.
    Title: GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in Glomerular Endothelial Cells.
  2. Role of GPR56 in Platelet Activation and Arterial Thrombosis.
    Title: Role of GPR56 in Platelet Activation and Arterial Thrombosis.
  3. GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
    Title: GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
  4. GPR56 S4 variant is required for microglia-mediated synaptic pruning.
    Title: GPR56 S4 variant is required for microglia-mediated synaptic pruning.
  5. Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation.
    Title: Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation.
  6. Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
    Title: Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
  7. Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
    Title: Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
  8. The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo.
    Title: The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo.
  9. Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
    Title: Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
  10. A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.
    Title: A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables collagen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex radial glia-guided migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebral cortex regionalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in layer formation in cerebral cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in glial limiting end-foot IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor G1
Names
G-protein coupled receptor 56
secretin receptor
serpentine receptor cyt28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198894.2 → NP_001185823.1  adhesion G-protein coupled receptor G1 isoform c precursor

    See identical proteins and their annotated locations for NP_001185823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC103935, AC129606
    Consensus CDS
    CCDS22553.1
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2
    Related
    ENSMUSP00000137520.2, ENSMUST00000179619.9
    Conserved Domains (5) summary
    cd14964
    Location:403 → 427
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:345 → 388
    GPS; GPCR proteolysis site, GPS, motif
    pfam18587
    Location:29 → 162
    PLL; PTX/LNS-Like (PLL) domain
    pfam18619
    Location:173 → 220
    GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
    cl28897
    Location:400 → 667
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001403764.1 → NP_001390693.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935, AC129606

  3. NM_001403765.1 → NP_001390694.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935, AC129606

  4. NM_001403766.1 → NP_001390695.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  5. NM_001403767.1 → NP_001390696.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  6. NM_001403768.1 → NP_001390697.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  7. NM_001403769.1 → NP_001390698.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  8. NM_001403770.1 → NP_001390699.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  9. NM_001403771.1 → NP_001390700.1  adhesion G-protein coupled receptor G1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  10. NM_001403772.1 → NP_001390701.1  adhesion G-protein coupled receptor G1 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  11. NM_001403776.1 → NP_001390705.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935, AC129606
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  12. NM_001403778.1 → NP_001390707.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  13. NM_001403779.1 → NP_001390708.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  14. NM_001403780.1 → NP_001390709.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  15. NM_001403781.1 → NP_001390710.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  16. NM_001403782.1 → NP_001390711.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  17. NM_001403783.1 → NP_001390712.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  18. NM_001403784.1 → NP_001390713.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935, AC129606
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  19. NM_001403785.1 → NP_001390714.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935, AC129606
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  20. NM_001403786.1 → NP_001390715.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  21. NM_001403787.1 → NP_001390716.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  22. NM_001403788.1 → NP_001390717.1  adhesion G-protein coupled receptor G1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2

  23. NM_001403789.1 → NP_001390718.1  adhesion G-protein coupled receptor G1 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  24. NM_001403790.1 → NP_001390719.1  adhesion G-protein coupled receptor G1 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC103935

  25. NM_018882.4 → NP_061370.2  adhesion G-protein coupled receptor G1 isoform c precursor

    See identical proteins and their annotated locations for NP_061370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC103935
    Consensus CDS
    CCDS22553.1
    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2
    Related
    ENSMUSP00000090959.7, ENSMUST00000093271.8
    Conserved Domains (5) summary
    cd14964
    Location:403 → 427
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:345 → 388
    GPS; GPCR proteolysis site, GPS, motif
    pfam18587
    Location:29 → 162
    PLL; PTX/LNS-Like (PLL) domain
    pfam18619
    Location:173 → 220
    GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
    cl28897
    Location:400 → 667
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95701321..95740836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530697.3 → XP_006530760.1  adhesion G-protein coupled receptor G1 isoform X7

    See identical proteins and their annotated locations for XP_006530760.1

    UniProtKB/Swiss-Prot
    Q3UR17, Q8K209, Q9QZT2
    Conserved Domains (5) summary
    cd14964
    Location:403 → 427
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:345 → 388
    GPS; GPCR proteolysis site, GPS, motif
    pfam18587
    Location:29 → 162
    PLL; PTX/LNS-Like (PLL) domain
    pfam18619
    Location:173 → 220
    GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
    cl28897
    Location:400 → 667
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006530691.5 → XP_006530754.1  adhesion G-protein coupled receptor G1 isoform X6

    See identical proteins and their annotated locations for XP_006530754.1

    Conserved Domains (5) summary
    cd14964
    Location:407 → 432
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:350 → 393
    GPS; GPCR proteolysis site, GPS, motif
    pfam18587
    Location:34 → 167
    PLL; PTX/LNS-Like (PLL) domain
    pfam18619
    Location:178 → 225
    GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
    cl28897
    Location:405 → 672
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006530689.4 → XP_006530752.1  adhesion G-protein coupled receptor G1 isoform X6

    See identical proteins and their annotated locations for XP_006530752.1

    Conserved Domains (5) summary
    cd14964
    Location:407 → 432
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:350 → 393
    GPS; GPCR proteolysis site, GPS, motif
    pfam18587
    Location:34 → 167
    PLL; PTX/LNS-Like (PLL) domain
    pfam18619
    Location:178 → 225
    GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
    cl28897
    Location:405 → 672
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_017312577.2 → XP_017168066.1  adhesion G-protein coupled receptor G1 isoform X5

    Conserved Domains (5) summary
    cd14964
    Location:415 → 440
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:358 → 401
    GPS; GPCR proteolysis site, GPS, motif
    pfam18587
    Location:42 → 175
    PLL; PTX/LNS-Like (PLL) domain
    pfam18619
    Location:186 → 233
    GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
    cl28897
    Location:413 → 680
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K209.1 GenPept UniProtKB/Swiss-Prot:Q8K209

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