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Pde7b phosphodiesterase 7B [ Rattus norvegicus (Norway rat) ]

Gene ID: 140929, updated on 5-Mar-2024

Summary

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Official Symbol
Pde7bprovided by RGD
Official Full Name
phosphodiesterase 7Bprovided by RGD
Primary source
RGD:621016
See related
Ensembl:ENSRNOG00000013436 AllianceGenome:RGD:621016
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Orthologous to human PDE7B (phosphodiesterase 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 117.0), Muscle (RPKM 90.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1p12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16994072..17312828, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (15174001..15493267, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15889845..16203909, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BCL2-associated transcription factor 1 Neighboring gene mitochondrial fission regulator 2 Neighboring gene uncharacterized LOC134484964 Neighboring gene uncharacterized LOC134484963 Neighboring gene histidine-rich glycoprotein-like Neighboring gene uncharacterized LOC120098802 Neighboring gene small nucleolar RNA SNORA41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons. Sasaki T, et al. J Neurochem, 2004 Apr. PMID 15056290
  2. Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation. Sasaki T, et al. Biochem J, 2002 Jan 15. PMID 11772393, Free PMC Article
  3. Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells. de Gortari P, et al. Brain Res, 2010 Jan 15. PMID 19913519
  4. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Gardner C, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872825
  5. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M, et al. Annu Rev Biochem, 2007. PMID 17376027

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. All MOR, D1 and D2 positive cells containing AC5 mRNA simultaneously express PDE7B in striatal rat cells.
    Title: Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells.
  2. These data demonstrate the dopamine D1 receptor-mediated transcriptional activation of PDE7B through the cAMP/cAMP-dependent protein kinase/cAMP-response element binding protein pathway in striatal neurons
    Title: Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 7B
Names
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
NP_543170.1
XP_008756813.1
XP_008756814.1
XP_038938754.1
XP_038938792.1
XP_038938818.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080894.2 → NP_543170.1  3',5'-cyclic-AMP phosphodiesterase 7B

    See identical proteins and their annotated locations for NP_543170.1

    Status: PROVISIONAL

    Source sequence(s)
    AB057409
    UniProtKB/TrEMBL
    A6JPD2, Q8VIE4
    Related
    ENSRNOP00000070401.1, ENSRNOT00000078586.2
    Conserved Domains (1) summary
    pfam00233
    Location:172 → 406
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    16994072..17312828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082826.2 → XP_038938754.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X2

    UniProtKB/TrEMBL
    A6JPD3
    Conserved Domains (1) summary
    pfam00233
    Location:224 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. XM_039082864.2 → XP_038938792.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X3

    UniProtKB/TrEMBL
    A0A8I6AIQ8, F1LN39, Q8VIE2
    Related
    ENSRNOP00000018556.6
    Conserved Domains (1) summary
    pfam00233
    Location:185 → 419
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_008758591.4 → XP_008756813.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWQ4, A6JPD3
    Related
    ENSRNOP00000083905.1
    Conserved Domains (1) summary
    pfam00233
    Location:224 → 458
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. XM_039082890.2 → XP_038938818.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X4

    UniProtKB/TrEMBL
    A0A8I6A9G5, Q8VIE3
    Conserved Domains (1) summary
    pfam00233
    Location:85 → 319
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. XM_008758592.4 → XP_008756814.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X4

    See identical proteins and their annotated locations for XP_008756814.1

    UniProtKB/TrEMBL
    A0A8I6A9G5, Q8VIE3
    Conserved Domains (1) summary
    pfam00233
    Location:85 → 319
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RNA

  1. XR_005488707.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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