Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igf2bp1provided by MGI
Official Full Name: insulin-like growth factor 2 mRNA binding protein 1provided by MGI
Primary source: MGI:MGI:1890357
See related: Ensembl:ENSMUSG00000013415 AllianceGenome:MGI:1890357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMP1; Zbp1; Crdbp; ZBP-1; CRD-BP; Neilsen; D11Moh45; mir-3063; D11Moh40e; D030026A21Rik
Summary: Predicted to enable mRNA 3'-UTR binding activity; mRNA 5'-UTR binding activity; and translation regulator activity. Acts upstream of or within neuronal stem cell population maintenance and pallium cell proliferation in forebrain. Predicted to be located in several cellular components, including cytoplasmic stress granule; dendritic spine; and neuronal cell body. Predicted to be part of CRD-mediated mRNA stability complex and ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including early conceptus; eye; forebrain; gonad; and intestine. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 17.9), placenta adult (RPKM 10.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.08 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (95847989..95896770, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (95957163..96005944, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification.
Title: The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification.
IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B.
Title: IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B.
RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.
Title: RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.
WTAP-mediated m6A modification on circCMTM3 inhibits hepatocellular carcinoma ferroptosis by recruiting IGF2BP1 to increase PARK7 stability.
Title: WTAP-mediated m6A modification on circCMTM3 inhibits hepatocellular carcinoma ferroptosis by recruiting IGF2BP1 to increase PARK7 stability.
IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis.
Title: IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis.
Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.
Title: Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.
Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1.
Title: Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1.
Tagged actin mRNA dysregulation in IGF2BP1[Formula: see text] mice.
Title: Tagged actin mRNA dysregulation in IGF2BP1[Formula: see text] mice.
Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages.
Title: Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages.
Longitudinal epitranscriptome profiling reveals the crucial role of N(6)-methyladenosine methylation in porcine prenatal skeletal muscle development.
Title: Longitudinal epitranscriptome profiling reveals the crucial role of N(6)-methyladenosine methylation in porcine prenatal skeletal muscle development.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (6)
Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548139

UniSTS:498743 (e-PCR)
- UniSTS:498743

Igf2bp1 (e-PCR), detects polymorphism
- UniSTS:498743

G38032 (e-PCR)
- UniSTS:105020

G38033 (e-PCR)
- UniSTS:105021

G38035 (e-PCR)
- UniSTS:105023

G38036 (e-PCR)
- UniSTS:105024

RH125577 (e-PCR)
- UniSTS:162391

G38059 (e-PCR)
- UniSTS:105047

NoName (e-PCR)
- UniSTS:236708

AW549074 (e-PCR)
- UniSTS:178360

Igf2bp1 (e-PCR), detects polymorphism
- UniSTS:479166

RH125465 (e-PCR)
- UniSTS:162284

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in CRD-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in RNA localization	ISO Inferred from Sequence Orthology more info
involved_in dendrite arborization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pallium cell proliferation in forebrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability involved in response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CRD-mediated mRNA stability complex	ISO Inferred from Sequence Orthology more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 1

Names: IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; VICKZ family member 1; coding region determinant binding protein; insulin-like growth factor 2 mRNA binding protein 1 dN CRDBP-2; insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP; insulin-like growth factor 2, binding protein 1; zipcode binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401454.1 → NP_001388383.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL603682, AL606704
NM_001401455.1 → NP_001388384.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL603682, AL606704
NM_001401456.1 → NP_001388385.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL603682, AL606704

UniProtKB/TrEMBL

A0A0H3XWX3
NM_001401457.1 → NP_001388386.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL603682, AL606704

UniProtKB/TrEMBL

A0A0H3XWX3
NM_009951.4 → NP_034081.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_034081.1

Status: VALIDATED

Source sequence(s)

AL603682, AL606704

Consensus CDS

CCDS25286.1

UniProtKB/Swiss-Prot

O88477, Q80US9, Q8BRH1

Related

ENSMUSP00000013559.3, ENSMUST00000013559.3

Conserved Domains (4) summary

cd00105
Location:279 → 344

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12625
Location:1 → 77

RRM1_IGF2BP1; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd12628
Location:81 → 156

RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

pfam00013
Location:408 → 471

KH_1; KH domain