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Cpeb1 cytoplasmic polyadenylation element binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 12877, updated on 25-Apr-2024

Summary

Official Symbol
Cpeb1provided by MGI
Official Full Name
cytoplasmic polyadenylation element binding protein 1provided by MGI
Primary source
MGI:MGI:108442
See related
Ensembl:ENSMUSG00000025586 AllianceGenome:MGI:108442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpeb; mCPEB; Cpe-bp1; mCpeb-1
Summary
Enables mRNA 3'-UTR AU-rich region binding activity and translation repressor activity, mRNA regulatory element binding. Involved in cellular response to amino acid stimulus; cellular response to hypoxia; and negative regulation of cytoplasmic translation. Acts upstream of or within regulation of neuronal synaptic plasticity; regulation of translation; and synaptonemal complex assembly. Located in several cellular components, including cytoplasm; meiotic spindle; and nucleus. Is expressed in brain; early embryo; olfactory epithelium; and reproductive system. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 9.8), frontal lobe adult (RPKM 9.6) and 15 other tissues See more
Orthologs
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Genomic context

Location:
7 D3; 7 45.71 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80996774..81105207, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81347026..81458001, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 8A Neighboring gene translocase of inner mitochondrial membrane 17a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88496762-88496958 Neighboring gene ribosomal protein S17 Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12) pseudogene Neighboring gene ribosomal protein L7A, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_19364 Neighboring gene adaptor-related protein complex 3, beta 2 subunit Neighboring gene cDNA sequence BC048679

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC159179

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA regulatory element binding translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translation at synapse, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translation at synapse, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
cytoplasmic polyadenylation element-binding protein 1
Names
CPE-binding protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252525.1NP_001239454.1  cytoplasmic polyadenylation element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001239454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK077799, BC125476, BY720025, CO803180
    Consensus CDS
    CCDS57557.1
    UniProtKB/TrEMBL
    F6X7Z3, Q059Z2
    Related
    ENSMUSP00000137079.2, ENSMUST00000178892.3
    Conserved Domains (4) summary
    cd12723
    Location:309416
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:427512
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:504559
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1307
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  2. NM_001252526.1NP_001239455.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK077799, BC125476, BC144948, BY720025, CO803180
    UniProtKB/TrEMBL
    F6X7Z3
    Related
    ENSMUSP00000120139.2, ENSMUST00000130310.8
    Conserved Domains (4) summary
    cd12723
    Location:308410
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:421506
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:498553
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1306
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  3. NM_001357107.1NP_001344036.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1. Variants 4 and 12-16 all encode the same isoform (4).
    Source sequence(s)
    AC162897, CO803180
    UniProtKB/TrEMBL
    F6X7Z3
    Conserved Domains (4) summary
    pfam16366
    Location:423478
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1231
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:233335
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:346429
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  4. NM_001412273.1NP_001399202.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  5. NM_001412274.1NP_001399203.1  cytoplasmic polyadenylation element-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  6. NM_001412275.1NP_001399204.1  cytoplasmic polyadenylation element-binding protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  7. NM_001412276.1NP_001399205.1  cytoplasmic polyadenylation element-binding protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  8. NM_001412277.1NP_001399206.1  cytoplasmic polyadenylation element-binding protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  9. NM_001412278.1NP_001399207.1  cytoplasmic polyadenylation element-binding protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  10. NM_001412279.1NP_001399208.1  cytoplasmic polyadenylation element-binding protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162897
  11. NM_001412280.1NP_001399209.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  12. NM_001412281.1NP_001399210.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  13. NM_001412282.1NP_001399211.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162897
  14. NM_001412283.1NP_001399212.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  15. NM_001412284.1NP_001399213.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162897
  16. NM_001412285.1NP_001399214.1  cytoplasmic polyadenylation element-binding protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  17. NM_001412286.1NP_001399215.1  cytoplasmic polyadenylation element-binding protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC162897, AC167120, AC169082
  18. NM_001412287.1NP_001399216.1  cytoplasmic polyadenylation element-binding protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC162897
  19. NM_007755.5NP_031781.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_031781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK077799, BC144948, BY720025, CO803180, Y08260
    Consensus CDS
    CCDS40007.1
    UniProtKB/Swiss-Prot
    P70166, Q8C5P9
    UniProtKB/TrEMBL
    F6X7Z3
    Related
    ENSMUSP00000095936.4, ENSMUST00000098331.10
    Conserved Domains (4) summary
    cd12723
    Location:308415
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:426511
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:503558
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1306
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80996774..81105207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242061.2XP_030097921.1  cytoplasmic polyadenylation element-binding protein 1 isoform X7

    UniProtKB/TrEMBL
    F6X7Z3
    Conserved Domains (4) summary
    cd12723
    Location:309399
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:410495
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:487513
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1307
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  2. XM_011250788.4XP_011249090.1  cytoplasmic polyadenylation element-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    F6X7Z3
    Conserved Domains (4) summary
    cd12723
    Location:347437
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:448533
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:525580
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:48345
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  3. XM_036152627.1XP_036008520.1  cytoplasmic polyadenylation element-binding protein 1 isoform X6

    UniProtKB/TrEMBL
    F6X7Z3
    Conserved Domains (4) summary
    pfam16366
    Location:524579
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:44344
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:346436
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:447530
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  4. XM_011250785.4XP_011249087.1  cytoplasmic polyadenylation element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    F6X7Z3
    Conserved Domains (4) summary
    cd12723
    Location:346453
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:464549
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:541596
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:48344
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  5. XM_011250784.4XP_011249086.1  cytoplasmic polyadenylation element-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    F6X7Z3
    Conserved Domains (4) summary
    cd12723
    Location:347454
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:465550
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:542597
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:48345
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  6. XM_011250790.4XP_011249092.1  cytoplasmic polyadenylation element-binding protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011249092.1

    UniProtKB/TrEMBL
    F6X7Z3
    Conserved Domains (4) summary
    cd12723
    Location:233340
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:351436
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:428483
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1231
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  7. XM_011250792.3XP_011249094.1  cytoplasmic polyadenylation element-binding protein 1 isoform X10

    Conserved Domains (4) summary
    cd12723
    Location:179286
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:297382
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:374429
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1177
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus