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Gng4 G protein subunit gamma 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114118, updated on 25-Apr-2024

Summary

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Symbol
Gng4provided by RGD
Full Name
G protein subunit gamma 4provided by RGD
Primary source
RGD:620806
See related
AllianceGenome:RGD:620806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg3c
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of cell growth. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNG4 (G protein subunit gamma 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 89.5) See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (93432791..93481709)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (86448708..86497560)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90266571..90316278, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482624 Neighboring gene lysosomal trafficking regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of novel VHL target genes and relationship to hypoxic response pathways. Maina EN, et al. Oncogene, 2005 Jun 30. PMID 15824735
  2. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Betty M, et al. Neuroscience, 1998 Jul. PMID 9622245
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Names
guanine nucleotide binding protein (G protein), gamma 4 subunit
guanine nucleotide binding protein 4
heterotrimeric guanine nucleotide-binding protein 3c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400370.1 → NP_001387299.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6KTD1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    93432791..93481709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771924.4 → XP_008770146.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1

    See identical proteins and their annotated locations for XP_008770146.1

    UniProtKB/TrEMBL
    A6KTD1
    Conserved Domains (1) summary
    smart00224
    Location:13 → 75
    GGL; G protein gamma subunit-like motifs
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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