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TENT4A terminal nucleotidyltransferase 4A [ Homo sapiens (human) ]

Gene ID: 11044, updated on 11-Apr-2024

Summary

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Official Symbol
TENT4Aprovided by HGNC
Official Full Name
terminal nucleotidyltransferase 4Aprovided by HGNC
Primary source
HGNC:HGNC:16705
See related
Ensembl:ENSG00000112941 MIM:605198; AllianceGenome:HGNC:16705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAK1; POLK; POLS; TRF4; LAK-1; PAPD7; TRF41; TRF4-1; TUTASE5
Summary
The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 5.8), skin (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5p15.31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (6713432..6757044)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (6644097..6687689)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (6713545..6757157)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900934 Neighboring gene long intergenic non-protein coding RNA 2102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22339 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:6726225-6727027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22342 Neighboring gene uncharacterized LOC107986401 Neighboring gene Sharpr-MPRA regulatory region 14782 Neighboring gene splicing factor 3A subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:6770439-6770938 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:6772403-6773602

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer. Swain U, et al. Int J Mol Sci, 2021 Jun 28. PMID 34203408, Free PMC Article
  2. Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7. Ogami K, et al. Biochem Biophys Res Commun, 2013 Mar 1. PMID 23376078
  3. Evidence that replication fork components catalyze establishment of cohesion between sister chromatids. Carson DR, et al. Proc Natl Acad Sci U S A, 2001 Jul 17. PMID 11459963, Free PMC Article
  4. Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Shukla S, et al. Blood Adv, 2020 Jun 23. PMID 32559291, Free PMC Article
  5. The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis. Li Y, et al. Proc Natl Acad Sci U S A, 2022 Jul 12. PMID 35867748, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.
    Title: The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.
  2. TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.
    Title: TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.
  3. Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita.
    Title: Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita.
  4. Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.
    Title: Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.
  5. TENT4A and TENT4B produce a mixed tail that shields mRNA from rapid deadenylation.
    Title: Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation.
  6. These results suggest that PAPD7 l is the major and active isoform of PAPD7 expressed in cells.
    Title: Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
EBI GWAS Catalog
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables SMC family protein binding TAS
Traceable Author Statement
more info
 PubMed 
enables guanylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome condensation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyadenylation-dependent ncRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sister chromatid cohesion TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
terminal nucleotidyltransferase 4A
Names
DNA polymerase kappa
DNA polymerase sigma
PAP-associated domain-containing protein 7
TRAMP-like complex polyadenylate polymerase
non-canonical poly(A) RNA polymerase PAPD7
poly(A) RNA polymerase D7, non-canonical
polymerase (DNA directed) sigma
terminal guanylyltransferase
terminal uridylyltransferase 5
topoisomerase-related function protein 4-1
NP_001165276.2
NP_008930.2
XP_016864477.1
XP_047272620.1
XP_047272621.1
XP_047272622.1
XP_047272623.1
XP_047272624.1
XP_054207474.1
XP_054207475.1
XP_054207476.1
XP_054207477.1
XP_054207478.1
XP_054207479.1
XP_054207480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171805.3 → NP_001165276.2  terminal nucleotidyltransferase 4A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB005754, AC122710, AI871781, BC143882, KC424495
    Conserved Domains (1) summary
    cl27230
    Location:240 → 545
    PAP_assoc; Cid1 family poly A polymerase

  2. NM_006999.6 → NP_008930.2  terminal nucleotidyltransferase 4A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB005754, AC122710, AK289857, BC084567, BC143882, KC424495
    Consensus CDS
    CCDS3871.2
    UniProtKB/Swiss-Prot
    A0A0X1KG68, A8K1E2, M1JCE6, O43289, Q17RZ1, Q5XG87, Q9Y6C1
    Related
    ENSP00000230859.7, ENST00000230859.8
    Conserved Domains (1) summary
    cl27230
    Location:240 → 545
    PAP_assoc; Cid1 family poly A polymerase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    6713432..6757044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416667.1 → XP_047272623.1  terminal nucleotidyltransferase 4A isoform X2

  2. XM_047416666.1 → XP_047272622.1  terminal nucleotidyltransferase 4A isoform X1

    UniProtKB/TrEMBL
    A0A9H4DBI9

  3. XM_047416664.1 → XP_047272620.1  terminal nucleotidyltransferase 4A isoform X1

    UniProtKB/TrEMBL
    A0A9H4DBI9

  4. XM_017008988.3 → XP_016864477.1  terminal nucleotidyltransferase 4A isoform X2

    UniProtKB/TrEMBL
    B7ZLL4
    Conserved Domains (1) summary
    COG5260
    Location:2 → 286
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  5. XM_047416668.1 → XP_047272624.1  terminal nucleotidyltransferase 4A isoform X3

  6. XM_047416665.1 → XP_047272621.1  terminal nucleotidyltransferase 4A isoform X1

    UniProtKB/TrEMBL
    A0A9H4DBI9
    Related
    ENSP00000488642.1, ENST00000631941.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    6644097..6687689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351504.1 → XP_054207479.1  terminal nucleotidyltransferase 4A isoform X2

  2. XM_054351499.1 → XP_054207474.1  terminal nucleotidyltransferase 4A isoform X4

  3. XM_054351500.1 → XP_054207475.1  terminal nucleotidyltransferase 4A isoform X1

    UniProtKB/TrEMBL
    A0A9H4DBI9

  4. XM_054351502.1 → XP_054207477.1  terminal nucleotidyltransferase 4A isoform X1

    UniProtKB/TrEMBL
    A0A9H4DBI9

  5. XM_054351503.1 → XP_054207478.1  terminal nucleotidyltransferase 4A isoform X2

  6. XM_054351505.1 → XP_054207480.1  terminal nucleotidyltransferase 4A isoform X3

  7. XM_054351501.1 → XP_054207476.1  terminal nucleotidyltransferase 4A isoform X1

    UniProtKB/TrEMBL
    A0A9H4DBI9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171806.1: Suppressed sequence

    Description
    NM_001171806.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XG87.4 GenPept UniProtKB/Swiss-Prot:Q5XG87

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