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C7 complement component 7 [ Mus musculus (house mouse) ]

Gene ID: 109828, updated on 25-Apr-2024

Summary

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Official Symbol
C7provided by MGI
Official Full Name
complement component 7provided by MGI
Primary source
MGI:MGI:88235
See related
Ensembl:ENSMUSG00000079105 AllianceGenome:MGI:88235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1238; A530026G17
Summary
Predicted to be part of membrane attack complex. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 23.3), genital fat pad adult (RPKM 21.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A1; 15 1.98 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5017232..5093230, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (4987750..5063773, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene maestro heat-like repeat family member 2B Neighboring gene STARR-seq mESC enhancer starr_37838 Neighboring gene STARR-seq mESC enhancer starr_37841 Neighboring gene predicted gene, 25652 Neighboring gene STARR-positive B cell enhancer ABC_E8583 Neighboring gene caspase recruitment domain family, member 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1171 Neighboring gene caspase recruitment domain family, member 6 Neighboring gene ribosomal protein L37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species. Zelek WM, et al. Front Immunol, 2020. PMID 33424866, Free PMC Article
  2. Complement factor C7 contributes to lung immunopathology caused by Mycobacterium tuberculosis. Welsh KJ, et al. Clin Dev Immunol, 2012. PMID 22973398, Free PMC Article
  3. Linkage between complement components 6 and 7 and glutamic pyruvate transaminase in the marsupial Monodelphis domestica. van Oorschot RA, et al. Biochem Genet, 1993 Jun. PMID 8259924
  4. Close linkage between mouse genes determining the two forms of complement component C6 and component C7, and cis action of a C6 regulatory gene. Orren A, et al. Immunogenetics, 1985. PMID 4007963
  5. Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis. Schauwecker PE, et al. J Comp Neurol, 2004 Sep 6. PMID 15281082

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immune response NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
complement component C7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243837.2 → NP_001230766.1  complement component C7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC115877, AC131919
    Consensus CDS
    CCDS56974.1
    UniProtKB/TrEMBL
    D3YXF5
    Related
    ENSMUSP00000106317.4, ENSMUST00000110689.5
    Conserved Domains (6) summary
    cd00033
    Location:631 → 689
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00057
    Location:772 → 841
    FIMAC; factor I membrane attack complex
    smart00209
    Location:503 → 549
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:249 → 448
    MACPF; membrane-attack complex / perforin
    cd00112
    Location:87 → 119
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00084
    Location:571 → 626
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    5017232..5093230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248274.1 → XP_030104134.1  complement component C7 isoform X1

    Conserved Domains (5) summary
    PHA02831
    Location:325 → 447
    PHA02831; EEV host range protein; Provisional
    smart00209
    Location:260 → 306
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:6 → 205
    MACPF; membrane-attack complex / perforin
    pfam18434
    Location:549 → 596
    Kazal_3; Kazal-type serine protease inhibitor domain
    cl20168
    Location:460 → 523
    Kazal_3; Kazal-type serine protease inhibitor domain

  2. XM_030248275.2 → XP_030104135.1  complement component C7 isoform X1

    Conserved Domains (5) summary
    PHA02831
    Location:325 → 447
    PHA02831; EEV host range protein; Provisional
    smart00209
    Location:260 → 306
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:6 → 205
    MACPF; membrane-attack complex / perforin
    pfam18434
    Location:549 → 596
    Kazal_3; Kazal-type serine protease inhibitor domain
    cl20168
    Location:460 → 523
    Kazal_3; Kazal-type serine protease inhibitor domain
Nucleotide Protein Strain
Heading Accession and Version

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