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Bsp black spleen [ Mus musculus (house mouse) ]

Gene ID: 103993, updated on 2-Jan-2024

Summary

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Official Symbol
Bspprovided by MGI
Official Full Name
black spleenprovided by MGI
Primary source
MGI:MGI:88210
See related
AllianceGenome:MGI:88210
Gene type
unknown
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus

Bibliography

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Related articles in PubMed

  1. Transcriptional regulation of bone sialoprotein gene expression by Osx. Yang Y, et al. Biochem Biophys Res Commun, 2016 Aug 5. PMID 27261434
  2. Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing. Monfoulet L, et al. Bone, 2010 Feb. PMID 19761880
  3. Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. Malaval L, et al. J Exp Med, 2008 May 12. PMID 18458111, Free PMC Article
  4. Genetic basis of susceptibility to splenic lipofuscinosis in mice. Crichton DN, et al. Genet Res, 1982 Jun. PMID 7117836
  5. Association of tenascin-W expression with mineralization in mouse calvarial development. Mikura A, et al. Congenit Anom (Kyoto), 2009 Jun. PMID 19489959

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies made so far highlight the role of BSP in skeletal mineralization, as well as its importance for proper osteoblast and osteoclast differentiation and activity, most prominently in primary/repair bone. [review]
    Title: The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics.
  2. Transfection assay demonstrated that Osx was able to activate Bsp promoter reporter in a dose-dependent manner. To define minimal region of Bsp promoter activated by Osx, a series of deletion mutants of Bsp promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich site was required for Bsp promoter activation by Osx.
    Title: Transcriptional regulation of bone sialoprotein gene expression by Osx.
  3. BSP, but not OPN, plays a role in primary bone formation and mineralization of newly formed bone during the process of cortical bone healing.
    Title: Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing.
  4. BSP deficiency impairs bone growth and mineralization, concomitant with reduced bone formation, but does not prevent the bone loss resulting from loss of mechanical stimulation.
    Title: Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description Tests
black spleen
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Other Names

  • splenic lipofuscinosis

Property

  • phenotype only

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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