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SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Bos taurus (cattle) ]

Gene ID: 100138040, updated on 8-Mar-2024

Summary

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Official Symbol
SOS2provided by VGNC
Official Full Name
SOS Ras/Rho guanine nucleotide exchange factor 2provided by VGNC
Primary source
VGNC:VGNC:54490
See related
BGD:BT15508; Ensembl:ENSBTAG00000005550
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (43052603..43158246, complement)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104973139 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene U6 spliceosomal RNA Neighboring gene U1 spliceosomal RNA Neighboring gene L-2-hydroxyglutarate dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43052603..43158246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997980.2 → XP_024853748.1  son of sevenless homolog 2

    UniProtKB/TrEMBL
    A0A3Q1MN28, F1N1J9
    Related
    ENSBTAP00000007299.6, ENSBTAT00000007299.7
    Conserved Domains (6) summary
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:207 → 387
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:774 → 1013
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam16768
    Location:1023 → 1142
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    cl23830
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4
Nucleotide Protein Strain
Heading Accession and Version

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