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lrp6 low density lipoprotein receptor-related protein 6 [ Danio rerio (zebrafish) ]

Gene ID: 100003877, updated on 11-Apr-2024

Summary

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Official Symbol
lrp6provided by ZNC
Official Full Name
low density lipoprotein receptor-related protein 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-090821-1
See related
AllianceGenome:ZFIN:ZDB-GENE-090821-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable Wnt-activated receptor activity and Wnt-protein binding activity. Acts upstream of or within with a positive effect on Wnt signaling pathway involved in dorsal/ventral axis specification and canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in posterior lateral line primordium. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (74609..100007)
106 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003336643.1 (627..1849, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (169406..194804, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336643.1 (627..1849, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:zfos-932h1.6 Neighboring gene MANSC domain containing 1 Neighboring gene dual specificity phosphatase 16 Neighboring gene cAMP responsive element binding protein-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. Mathew LK, et al. FASEB J, 2008 Aug. PMID 18495758, Free PMC Article
  2. Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin. Jiang Y, et al. EMBO J, 2012 May 16. PMID 22491013, Free PMC Article
  3. Wnt ligand-dependent activation of the negative feedback regulator Nkd1. Larraguibel J, et al. Mol Biol Cell, 2015 Jun 15. PMID 25904337, Free PMC Article
  4. Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. Brock CK, et al. Nat Commun, 2019 Mar 5. PMID 30837472, Free PMC Article
  5. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenins in teleost fishes. Reading BJ, et al. J Lipid Res, 2014 Nov. PMID 25217480, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Waif1a binds to the Wnt coreceptor LRP6 and inhibits Wnt-induced LRP6 internalization into endocytic vesicles, a process that is required for pathway activation.
    Title: Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization.
  2. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling.
    Title: G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134684.1 → NP_001128156.1  low-density lipoprotein receptor-related protein 6 precursor

    See identical proteins and their annotated locations for NP_001128156.1

    Status: PROVISIONAL

    Source sequence(s)
    EU395842
    UniProtKB/TrEMBL
    B5L5I6
    Conserved Domains (6) summary
    smart00135
    Location:401 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1330 → 1364
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:53 → 93
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:152 → 192
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:289 → 326
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:32 → 158
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    74609..100007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 Primary Assembly

Genomic

  1. NW_003336643.1 Reference GRCz11 Primary Assembly

    Range
    627..1849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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