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prkcg protein kinase C, gamma [ Danio rerio (zebrafish) ]

Gene ID: 100003514, updated on 11-Apr-2024

Summary

Official Symbol
prkcgprovided by ZNC
Official Full Name
protein kinase C, gammaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090206-1
See related
Ensembl:ENSDARG00000004561 AllianceGenome:ZFIN:ZDB-GENE-090206-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-209f7.1
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within receptor recycling and synapse maturation. Predicted to be located in cytoplasm and membrane. Is expressed in brain; neurons; and spinal cord. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 16
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (13013320..13112721, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (13129893..13222555, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 8b Neighboring gene calcium channel, voltage-dependent, gamma subunit 7b Neighboring gene glutamate receptor ionotropic, NMDA 2D-like Neighboring gene phosphatidylinositol transfer protein cytoplasmic 1b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein kinase C alpha type-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    13013320..13112721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001921680.5XP_001921715.1  protein kinase C alpha type-like

    UniProtKB/TrEMBL
    A0A8M1QQZ0
    Related
    ENSDARP00000123279.1, ENSDART00000142610.3
    Conserved Domains (4) summary
    cd04026
    Location:178308
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:363621
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:366684
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:56108
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. XR_001796050.2 RNA Sequence