itgb3b integrin beta 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itgb3bprovided by ZNC
Official Full Name: integrin beta 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-071207-2
See related: Ensembl:ENSDARG00000045070 AllianceGenome:ZFIN:ZDB-GENE-071207-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: itgb3.1
Summary: Predicted to enable fibronectin binding activity and integrin binding activity. Predicted to contribute to fibrinogen binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within platelet aggregation. Part of integrin complex. Is expressed in brain; cardiovascular system; dental epithelium; digestive system; and pectoral fin fold. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (26436104..26461744)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (26344744..26370384)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta3.1 is the major beta3 paralog that associates with alphaV in zebrafish;pharyngeal dentitions appear to represent a unique expression field for alphaV and beta3.
Title: The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to fibrinogen binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: integrin beta-3b

Names: integrin beta 3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082948.1 → NP_001076417.1 integrin beta-3b precursor

See identical proteins and their annotated locations for NP_001076417.1

Status: PROVISIONAL

Source sequence(s)

DQ178646

UniProtKB/TrEMBL

Q3LTM5

Related

ENSDARP00000023822.8, ENSDART00000006908.9

Conserved Domains (3) summary

pfam00362
Location:37 → 463

Integrin_beta; Integrin, beta chain

pfam07965
Location:635 → 718

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:745 → 787

Integrin_b_cyt; Integrin beta cytoplasmic domain