A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
Entry Term(s)
Dishevelled Protein
Dishevelled-1 Protein
Dishevelled-2 Protein
Dishevelled-3 Protein
Registry Number
0
Public MeSH Note
2017; DISHEVELLED PROTEINS was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2006-2016; under PHOSPHOPROTEINS 1998-2016; and under PROTEINS 1994-1997
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
