Hmdb loader
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-05-22 15:12:46 UTC
Update Date2023-02-21 17:16:34 UTC
HMDB IDHMDB0003276
Secondary Accession Numbers
  • HMDB03276
Metabolite Identification
Common NameHydrogen sulfide
DescriptionHydrogen sulfide is a highly toxic and flammable gas. Because it is heavier than air it tends to accumulate at the bottom of poorly ventilated spaces. Although very pungent at first, it quickly deadens the sense of smell, so potential victims may be unaware of its presence until it is too late. H2S arises from virtually anywhere where elemental sulfur comes into contact with organic material, especially at high temperatures. Hydrogen sulfide is a covalent hydride chemically related to water (H2O) since oxygen and sulfur occur in the same periodic table group. It often results when bacteria break down organic matter in the absence of oxygen, such as in swamps, and sewers (alongside the process of anaerobic digestion). It also occurs in volcanic gases, natural gas and some well waters. It is also important to note that Hydrogen sulfide is a central participant in the sulfur cycle, the biogeochemical cycle of sulfur on Earth. As mentioned above, sulfur-reducing and sulfate-reducing bacteria derive energy from oxidizing hydrogen or organic molecules in the absence of oxygen by reducing sulfur or sulfate to hydrogen sulfide. Other bacteria liberate hydrogen sulfide from sulfur-containing amino acids. Several groups of bacteria can use hydrogen sulfide as fuel, oxidizing it to elemental sulfur or to sulfate by using oxygen or nitrate as oxidant. The purple sulfur bacteria and the green sulfur bacteria use hydrogen sulfide as electron donor in photosynthesis, thereby producing elemental sulfur. (In fact, this mode of photosynthesis is older than the mode of cyanobacteria, algae and plants which uses water as electron donor and liberates oxygen). Hydrogen sulfide can be found in Alcaligenes, Chromobacteriumn, Klebsiella, Proteus and Pseudomonas (PMID: 13061742 ).
Structure
Data?1676999794
Synonyms
ValueSource
[SH2]ChEBI
Acide sulfhydriqueChEBI
Dihydrogen monosulfideChEBI
Dihydrogen sulfideChEBI
H2SChEBI
Hydrogen monosulfideChEBI
Hydrogen sulphideChEBI
Hydrogen-sulfideChEBI
Hydrogene sulfureChEBI
HYDROsulfURIC ACIDChEBI
SchwefelwasserstoffChEBI
SulfideChEBI
Sulfure d'hydrogeneChEBI
Acide sulphhydriqueGenerator
Dihydrogen monosulphideGenerator
Dihydrogen sulphideGenerator
Hydrogen monosulphideGenerator
Hydrogen-sulphideGenerator
Hydrogene sulphureGenerator
HYDROsulfateGenerator
HYDROsulphateGenerator
HYDROsulphuric acidGenerator
SulphideGenerator
Sulphure d'hydrogeneGenerator
Dihydrogen disulfideHMDB
HepatateHMDB
Hepatic acidHMDB
Hepatic gasHMDB
HydrosulfurateHMDB
Idrogeno solforatoHMDB
Sewer gasHMDB
SiarkowodorHMDB
Sour gasHMDB
Stink dAMPHMDB
Sulfur hydrideHMDB
Sulfur hydroxideHMDB
Sulfureted hydrogenHMDB
Sulfuretted hydrogenHMDB
ZwavelwaterstofHMDB
Sulfide, hydrogenHMDB
Hydrogen sulfide (H2(SX))HMDB
Hydrogen sulfide (H2S2)HMDB
Hydrogen sulfide (H2S3)HMDB
Chemical FormulaH2S
Average Molecular Weight34.081
Monoisotopic Molecular Weight33.987720754
IUPAC Namehydrogen sulfide
Traditional Namehydrogen sulfide
CAS Registry Number7783-06-4
SMILES
S
InChI Identifier
InChI=1S/H2S/h1H2
InChI KeyRWSOTUBLDIXVET-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as other non-metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of other non-metals.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassOther non-metal organides
Sub ClassOther non-metal sulfides
Direct ParentOther non-metal sulfides
Alternative Parents
Substituents
  • Other non-metal sulfide
  • Inorganic sulfide
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effect
Disposition
Biological locationSource
Process
Role
Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting Point-85.49 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility3.74 mg/mL at 21 °CNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP-0.038ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity7.36 m³·mol⁻¹ChemAxon
Polarizability3.45 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Hydrogen sulfideS807.6Standard polar33892256
Hydrogen sulfideS331.1Standard non polar33892256
Hydrogen sulfideS202.9Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Hydrogen sulfide GC-MS (2 TMS)splash10-03di-1900000000-447434090a2b915c17312014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Hydrogen sulfide GC-MS (Non-derivatized)splash10-03di-1900000000-447434090a2b915c17312017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydrogen sulfide GC-MS (Non-derivatized) - 70eV, Positivesplash10-001i-9000000000-3a89a2549173c5c1687f2016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydrogen sulfide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydrogen sulfide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-001i-9000000000-5373be1d46feb66d09a82015-03-01Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 10V, Positive-QTOFsplash10-001i-9000000000-2d63abb89fd699a317072015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 20V, Positive-QTOFsplash10-001i-9000000000-2d63abb89fd699a317072015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 40V, Positive-QTOFsplash10-001i-9000000000-2d63abb89fd699a317072015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 10V, Positive-QTOFsplash10-001i-9000000000-2d63abb89fd699a317072015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 20V, Positive-QTOFsplash10-001i-9000000000-2d63abb89fd699a317072015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 40V, Positive-QTOFsplash10-001i-9000000000-2d63abb89fd699a317072015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 10V, Negative-QTOFsplash10-001i-9000000000-05710009cb2405db27bd2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 20V, Negative-QTOFsplash10-001i-9000000000-05710009cb2405db27bd2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 40V, Negative-QTOFsplash10-001i-9000000000-05710009cb2405db27bd2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 10V, Negative-QTOFsplash10-001i-9000000000-05710009cb2405db27bd2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 20V, Negative-QTOFsplash10-001i-9000000000-05710009cb2405db27bd2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 40V, Negative-QTOFsplash10-001i-9000000000-05710009cb2405db27bd2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 10V, Negative-QTOFsplash10-001i-9000000000-942ac689538269d6ca7b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 20V, Negative-QTOFsplash10-001i-9000000000-942ac689538269d6ca7b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 40V, Negative-QTOFsplash10-001i-9000000000-942ac689538269d6ca7b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 10V, Positive-QTOFsplash10-001i-9000000000-db65f6d26b49c63007062021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 20V, Positive-QTOFsplash10-001i-9000000000-db65f6d26b49c63007062021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydrogen sulfide 40V, Positive-QTOFsplash10-001i-9000000000-db65f6d26b49c63007062021-09-22Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Feces
Tissue Locations
  • Brain
  • Intestine
  • Neuron
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified65.70 +/- 5.50 uMChildren (1-13 years old)BothNormal details
BloodDetected and Quantified37.6 (27.4-41.3) uMAdult (>18 years old)BothNormal details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified51.93 +/- 6.01 uMChildren (1-13 years old)BothPrimary hypertension details
BloodDetected and Quantified36.2 (17.1-66.3) uMAdult (>18 years old)MaleOsteoarthritis details
BloodDetected and Quantified36.6 (30.6-49.2) uMAdult (>18 years old)BothRheumatoid arthritis details
Associated Disorders and Diseases
Disease References
Hydrogen sulfide poisoning
  1. Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG: Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Ann N Y Acad Sci. 2010 Aug;1203:146-50. doi: 10.1111/j.1749-6632.2010.05556.x. [PubMed:20716297 ]
Osteoarthritis
  1. Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG: Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Ann N Y Acad Sci. 2010 Aug;1203:146-50. doi: 10.1111/j.1749-6632.2010.05556.x. [PubMed:20716297 ]
Essential hypertension
  1. Chen L, Ingrid S, Ding YG, Liu Y, Qi JG, Tang CS, DU JB: Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children. Chin Med J (Engl). 2007 Mar 5;120(5):389-93. [PubMed:17376309 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB030910
KNApSAcK IDC00007266
Chemspider ID391
KEGG Compound IDC00283
BioCyc IDHS
BiGG IDNot Available
Wikipedia LinkHydrogen_sulfide
METLIN ID3193
PubChem Compound402
PDB IDNot Available
ChEBI ID16136
Food Biomarker OntologyNot Available
VMH IDH2S
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Jiang T, Suarez FL, Levitt MD, Nelson SE, Ziegler EE: Gas production by feces of infants. J Pediatr Gastroenterol Nutr. 2001 May;32(5):534-41. [PubMed:11429513 ]
  2. Boehning D, Snyder SH: Novel neural modulators. Annu Rev Neurosci. 2003;26:105-31. [PubMed:14527267 ]
  3. Kresimon J, Gruter UM, Hirner AV: HG/LT-GC/ICP-MS coupling for identification of metal(loid) species in human urine after fish consumption. Fresenius J Anal Chem. 2001 Nov;371(5):586-90. [PubMed:11767883 ]
  4. Kage S, Takekawa K, Kurosaki K, Imamura T, Kudo K: The usefulness of thiosulfate as an indicator of hydrogen sulfide poisoning: three cases. Int J Legal Med. 1997;110(4):220-2. [PubMed:9274948 ]
  5. Kaplan WD, Piez CW, Gelman RS, Laffin SM, Rosenbaum EM, Jennings CA, McCormick CA, Harris JR, Henderson IC, Atkins HL: Clinical comparison of two radiocolloids for internal mammary lymphoscintigraphy. J Nucl Med. 1985 Dec;26(12):1382-5. [PubMed:4067640 ]
  6. Naidong W, Shou WZ, Addison T, Maleki S, Jiang X: Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE. Rapid Commun Mass Spectrom. 2002;16(20):1965-75. [PubMed:12362389 ]
  7. Claesson R, Granlund-Edstedt M, Persson S, Carlsson J: Activity of polymorphonuclear leukocytes in the presence of sulfide. Infect Immun. 1989 Sep;57(9):2776-81. [PubMed:2547720 ]
  8. Quirynen M, Zhao H, Avontroodt P, Soers C, Pauwels M, Coucke W, van Steenberghe D: A salivary incubation test for evaluation of oral malodor: a pilot study. J Periodontol. 2003 Jul;74(7):937-44. [PubMed:12931755 ]
  9. Donham KJ, Zejda JE: Lung dysfunction in animal confinement workers--chairman's report to the Scientific Committee of the Third International Symposium: issues in health, safety and agriculture, held in Saskatoon, Saskatchewan, Canada, May 10-15, 1992. Pol J Occup Med Environ Health. 1992;5(3):277-9. [PubMed:1362681 ]
  10. Reid JS, Beeley JA, MacDonald DG: Investigations into black extrinsic tooth stain. J Dent Res. 1977 Aug;56(8):895-9. [PubMed:270488 ]
  11. Chen X, Jhee KH, Kruger WD: Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J Biol Chem. 2004 Dec 10;279(50):52082-6. Epub 2004 Nov 1. [PubMed:15520012 ]
  12. Warren YA, Citron DM, Merriam CV, Goldstein EJ: Biochemical differentiation and comparison of Desulfovibrio species and other phenotypically similar genera. J Clin Microbiol. 2005 Aug;43(8):4041-5. [PubMed:16081948 ]
  13. Livermore A, Hummel T, Kobal G: Chemosensory event-related potentials in the investigation of interactions between the olfactory and the somatosensory (trigeminal) systems. Electroencephalogr Clin Neurophysiol. 1992 Sep;83(3):201-10. [PubMed:1381671 ]
  14. Xu C, Li CY, Kong AN: Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res. 2005 Mar;28(3):249-68. [PubMed:15832810 ]
  15. Jorgensen J, Mortensen PB: Hydrogen sulfide and colonic epithelial metabolism: implications for ulcerative colitis. Dig Dis Sci. 2001 Aug;46(8):1722-32. [PubMed:11508674 ]
  16. Kage S, Ito S, Kishida T, Kudo K, Ikeda N: A fatal case of hydrogen sulfide poisoning in a geothermal power plant. J Forensic Sci. 1998 Jul;43(4):908-10. [PubMed:9670519 ]
  17. Kage S, Kashimura S, Ikeda H, Kudo K, Ikeda N: Fatal and nonfatal poisoning by hydrogen sulfide at an industrial waste site. J Forensic Sci. 2002 May;47(3):652-5. [PubMed:12051356 ]
  18. CLARKE PH: Hydrogen sulphide production by bacteria. J Gen Microbiol. 1953 Jun;8(3):397-407. doi: 10.1099/00221287-8-3-397. [PubMed:13061742 ]

Only showing the first 10 proteins. There are 27 proteins in total.

Enzymes

General function:
Involved in pyridoxal phosphate binding
Specific function:
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.
Gene Name:
CTH
Uniprot ID:
P32929
Molecular weight:
41259.91
Reactions
L-Cysteine + Water → Hydrogen sulfide + Pyruvic acid + Ammoniadetails
General function:
Involved in cysteine biosynthetic process from serine
Specific function:
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).
Gene Name:
CBS
Uniprot ID:
P35520
Molecular weight:
60586.05
Reactions
L-Serine + Hydrogen sulfide → L-Cysteine + Waterdetails
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
General function:
Involved in monooxygenase activity
Specific function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular weight:
57756.285
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Molecular weight:
60845.33
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular weight:
55710.075
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Gene Name:
CYP2F1
Uniprot ID:
P24903
Molecular weight:
55500.64

Only showing the first 10 proteins. There are 27 proteins in total.