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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-20 22:13:12 UTC
Update Date2023-02-21 17:15:48 UTC
HMDB IDHMDB0001624
Secondary Accession Numbers
  • HMDB01624
Metabolite Identification
Common Name2-Hydroxycaproic acid
Description2-hydroxycaproic acid, also known as 2-hydroxyhexanoic acid is a hydroxy fatty acid that is caproic (hexanoic) acid substituted by a hydroxy group at position 2. It has a role as an animal metabolite. It derives from a hexanoic acid. It is a conjugate acid of a 2-hydroxyhexanoate. 2-hydroxycaproic acid is a branched-chain alpha-keto acid that have been reported in normal human blood (PMID:7130306 ) and in normal amniotic fluid (PMID:7076774 ). It has been found that 2-hydroxycaproic acid is the most significant metabolite found in the CSF of patients infected with Nocardia. Nocardia sp. is an uncommon cause of meningitis, and Nocardia meningitis has a clinical picture similar to that of tuberculous meningitis (PMID:3818936 ; PMID:20615997 ).
Structure
Data?1676999748
Synonyms
ValueSource
2-HydroxycaproateGenerator
2-HydroxyhexanoateHMDB
2-Hydroxyhexanoic acidHMDB
DL-2-HydroxycaproateHMDB
DL-2-Hydroxycaproic acidHMDB
DL-2-HydroxyhexanoateHMDB
DL-2-Hydroxyhexanoic acidHMDB
DL-2-Hydroxyhexanoic acidhydroxyhexanoateHMDB
DL-2-Hydroxyhexanoic acidhydroxyhexanoic acidHMDB
DL-HydroxycaproateHMDB
DL-Hydroxycaproic acidHMDB
Hydroxy-N-caproateHMDB
Hydroxy-N-caproic acidHMDB
HydroxycaproateHMDB
Hydroxycaproic acidHMDB
HydroxyhexanoateHMDB
Hydroxyhexanoic acidHMDB
2-Hydroxycaproic acidChEBI
DL-2-Hydroxy caproateGenerator, HMDB
Chemical FormulaC6H12O3
Average Molecular Weight132.1577
Monoisotopic Molecular Weight132.07864425
IUPAC Name2-hydroxyhexanoic acid
Traditional Namehydroxyhexanoate
CAS Registry Number6064-63-7
SMILES
CCCCC(O)C(O)=O
InChI Identifier
InChI=1S/C6H12O3/c1-2-3-4-5(7)6(8)9/h5,7H,2-4H2,1H3,(H,8,9)
InChI KeyNYHNVHGFPZAZGA-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as medium-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassFatty acids and conjugates
Direct ParentMedium-chain fatty acids
Alternative Parents
Substituents
  • Medium-chain fatty acid
  • Hydroxy fatty acid
  • Alpha-hydroxy acid
  • Hydroxy acid
  • Monosaccharide
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Alcohol
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Organooxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point55 - 58 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility88.5 g/LALOGPS
logP0.86ALOGPS
logP0.94ChemAxon
logS-0.17ALOGPS
pKa (Strongest Acidic)4.26ChemAxon
pKa (Strongest Basic)-3.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity32.57 m³·mol⁻¹ChemAxon
Polarizability14.04 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+128.54331661259
DarkChem[M-H]-124.97831661259
AllCCS[M+H]+132.67432859911
AllCCS[M-H]-128.52132859911
DeepCCS[M+H]+133.27430932474
DeepCCS[M-H]-130.5130932474
DeepCCS[M-2H]-166.88230932474
DeepCCS[M+Na]+141.64730932474
AllCCS[M+H]+132.732859911
AllCCS[M+H-H2O]+128.532859911
AllCCS[M+NH4]+136.632859911
AllCCS[M+Na]+137.732859911
AllCCS[M-H]-128.532859911
AllCCS[M+Na-2H]-131.232859911
AllCCS[M+HCOO]-134.232859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
2-Hydroxycaproic acidCCCCC(O)C(O)=O2040.7Standard polar33892256
2-Hydroxycaproic acidCCCCC(O)C(O)=O1074.7Standard non polar33892256
2-Hydroxycaproic acidCCCCC(O)C(O)=O1167.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
2-Hydroxycaproic acid,1TMS,isomer #1CCCCC(O[Si](C)(C)C)C(=O)O1239.2Semi standard non polar33892256
2-Hydroxycaproic acid,1TMS,isomer #2CCCCC(O)C(=O)O[Si](C)(C)C1171.3Semi standard non polar33892256
2-Hydroxycaproic acid,2TMS,isomer #1CCCCC(O[Si](C)(C)C)C(=O)O[Si](C)(C)C1280.9Semi standard non polar33892256
2-Hydroxycaproic acid,1TBDMS,isomer #1CCCCC(O[Si](C)(C)C(C)(C)C)C(=O)O1447.5Semi standard non polar33892256
2-Hydroxycaproic acid,1TBDMS,isomer #2CCCCC(O)C(=O)O[Si](C)(C)C(C)(C)C1393.7Semi standard non polar33892256
2-Hydroxycaproic acid,2TBDMS,isomer #1CCCCC(O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C1696.3Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxycaproic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-002f-9000000000-8a7d8360cf90ac0786f62017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxycaproic acid GC-MS (2 TMS) - 70eV, Positivesplash10-009i-9430000000-1998df84d5020aa101f42017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxycaproic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid Quattro_QQQ 10V, Negative-QTOF (Annotated)splash10-0019-9600000000-10146667ecdae4cce5b22012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid Quattro_QQQ 25V, Negative-QTOF (Annotated)splash10-000b-9000000000-c862568de48398a07c5a2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid Quattro_QQQ 40V, Negative-QTOF (Annotated)splash10-0002-9200000000-f1ecc474a71b65c8401b2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative-QTOFsplash10-001i-0900000000-e7e9ac132b84240918a72012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative-QTOFsplash10-000i-9400000000-acfd79e3f78eb9bbdde92012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative-QTOFsplash10-000i-9000000000-174fc428947a51fb1c482012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative-QTOFsplash10-001r-9000000000-3c2f2415c8308cc882bf2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative-QTOFsplash10-001i-9000000000-c1e754811538f745822e2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ , negative-QTOFsplash10-001i-0900000000-e7e9ac132b84240918a72017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ , negative-QTOFsplash10-000i-9400000000-acfd79e3f78eb9bbdde92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ , negative-QTOFsplash10-000i-9000000000-174fc428947a51fb1c482017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ , negative-QTOFsplash10-001r-9000000000-3c2f2415c8308cc882bf2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxycaproic acid LC-ESI-QQ , negative-QTOFsplash10-001i-9000000000-c1e754811538f745822e2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 10V, Positive-QTOFsplash10-0159-4900000000-6aef6b562dd04c12e7b82017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 20V, Positive-QTOFsplash10-0ap0-9300000000-f45f59d1359081efdc5d2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 40V, Positive-QTOFsplash10-0a4l-9000000000-a3e49c43493abd03741a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 10V, Negative-QTOFsplash10-001i-3900000000-e83a45b173d15048668b2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 20V, Negative-QTOFsplash10-01p9-9500000000-b23fa478546cbc48f8492017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 40V, Negative-QTOFsplash10-0a4r-9000000000-3753a08be3115affee2a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 10V, Positive-QTOFsplash10-014i-9100000000-316563e9a011143375072021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 20V, Positive-QTOFsplash10-014j-9000000000-3eea8ca9bc19bab592492021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 40V, Positive-QTOFsplash10-052f-9000000000-a7ca27b940e9d0405fc52021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 10V, Negative-QTOFsplash10-001i-0900000000-b6e66d9d081f58fb31bf2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 20V, Negative-QTOFsplash10-001r-8900000000-03efd492d4589148581d2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxycaproic acid 40V, Negative-QTOFsplash10-0006-9100000000-9c86d81baaa70a16deca2021-09-22Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Experimental 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)2012-12-04Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)2012-12-05Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Feces
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
UrineDetected and Quantified0.0 umol/mmol creatinineChildren (1 - 18 years old)Both
Normal
    • BC Children's Hos...
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022697
KNApSAcK IDNot Available
Chemspider ID90191
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID6332
PubChem Compound99824
PDB IDNot Available
ChEBI ID86542
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceAbderhalden, Emil; Weil, Arthur. A New Amino Acid of the Composition C6H13NO3, Obtained by the Total Hydrolysis of Nerve Proteins. Z. physiol. Chem. (1913), 84 39-59.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Woolf LI, Hasinoff C, Perry A: Estimation of branched-chain alpha-keto acids in blood by gas chromatography. J Chromatogr. 1982 Sep 10;231(2):237-45. [PubMed:7130306 ]
  2. Ng KJ, Andresen BD, Bianchine JR, Iams JD, O'Shaugnessy RW, Stempel LE, Zuspan FP: Capillary gas chromatographic-mass spectrometric profiles of trimethylsilyl derivatives of organic acids from amniotic fluids of different gestational age. J Chromatogr. 1982 Mar 12;228:43-50. [PubMed:7076774 ]
  3. Brooks JB, Kasin JV, Fast DM, Daneshvar MI: Detection of metabolites by frequency-pulsed electron capture gas-liquid chromatography in serum and cerebrospinal fluid of a patient with Nocardia infection. J Clin Microbiol. 1987 Feb;25(2):445-8. [PubMed:3818936 ]
  4. van Duynhoven J, Vaughan EE, Jacobs DM, Kemperman RA, van Velzen EJ, Gross G, Roger LC, Possemiers S, Smilde AK, Dore J, Westerhuis JA, Van de Wiele T: Metabolic fate of polyphenols in the human superorganism. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4531-8. doi: 10.1073/pnas.1000098107. Epub 2010 Jun 25. [PubMed:20615997 ]