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Showing metabocard for (R)-Lipoic acid (HMDB0001451)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:43 UTC
HMDB IDHMDB0001451
Secondary Accession Numbers
  • HMDB01451
Metabolite Identification
Common Name(R)-Lipoic acid
DescriptionLipoic acid is a vitamin-like antioxidant that acts as a free-radical scavenger. Alpha-lipoic acid is also known as thioctic acid. It is a naturally occurring compound that is synthesized by both plants and animals. Lipoic acid contains two thiol groups which may be either oxidized or reduced. The reduced form is known as dihydrolipoic acid (DHLA). Lipoic acid (Delta E= -0.288) is therefore capable of thiol-disulfide exchange, giving it antioxidant activity. Lipoate is a critical cofactor for aerobic metabolism, participating in the transfer of acyl or methylamine groups via the 2-Oxoacid dehydrogenase (2-OADH) or alpha-ketoglutarate dehydrogenase complex. This enzyme catalyzes the conversion of alpha-ketoglutarate to succinyl CoA. This activity results in the catabolism of the branched chain amino acids (leucine, isoleucine and valine). Lipoic acid also participates in the glycine cleavage system(GCV). The glycine cleavage system is a multi-enzyme complex that catalyzes the oxidation of glycine to form 5,10 methylene tetrahydrofolate, an important cofactor in nucleic acid synthesis. Since Lipoic acid is an essential cofactor for many enzyme complexes, it is essential for aerobic life as we know it. This system is used by many organisms and plays a crucial role in the photosynthetic carbon cycle. Lipoic acid was first postulated to be an effective antioxidant when it was found it prevented vitamin C and vitamin E deficiency. It is able to scavenge reactive oxygen species and reduce other metabolites, such as glutathione or vitamins, maintaining a healthy cellular redox state. Lipoic acid has been shown in cell culture experiments to increase cellular uptake of glucose by recruiting the glucose transporter GLUT4 to the cell membrane, suggesting its use in diabetes. Studies of rat aging have suggested that the use of L-carnitine and lipoic acid results in improved memory performance and delayed structural mitochondrial decay. As a result, it may be helpful for people with Alzheimer's disease or Parkinson's disease.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0001451 ((R)-Lipoic acid)

  Mrv1652305261923502D          

 12 12  0  0  0  0            999 V2000
   -0.0308    0.7026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3817   -0.5669    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6982    0.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4433   -0.5669    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6366    0.2177    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3511    0.6302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0656    0.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7801    0.6302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4945    0.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090    0.6302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090    1.4552    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9235    0.2177    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  5  1  1  0  0  0  0
  5  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  4  1  0  0  0  0
  5  6  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 12  1  0  0  0  0
 10 11  2  0  0  0  0
M  END
Download

3D MOL for HMDB0001451 ((R)-Lipoic acid)

HMDB0001451
     RDKit          3D
(R)-Lipoic acid
 26 26  0  0  0  0  0  0  0  0999 V2000
    3.4270   -0.3763   -1.0240 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3522   -0.5691    0.2013 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -1.2350    0.8430 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2335   -0.1546    1.0445 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1383    0.4575    0.2378 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5748   -0.5409   -0.7426 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5328    0.0606   -1.5689 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6268    0.5141   -0.7002 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.2945   -0.5100    0.1483 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1669    0.2725    1.1411 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4493    0.9129   -0.0203 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0697    1.1240   -1.6813 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.3410   -1.0602    0.4779 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5472    0.5136    1.8822 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8774   -1.0876    1.5763 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4708    1.3925   -0.2858 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3369    0.8126    0.9506 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1907   -1.3998   -0.1283 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2945   -0.9652   -1.4404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8418   -0.5715   -2.4023 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0840    0.9828   -2.0441 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3209    1.3671   -0.0638 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6585   -1.2312    0.6509 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0241   -1.0940   -0.4647 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5354    1.0924    1.5186 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5944   -0.3788    1.8941 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  8  1  0
  3 13  1  0
  4 14  1  0
  4 15  1  0
  5 16  1  0
  5 17  1  0
  6 18  1  0
  6 19  1  0
  7 20  1  0
  7 21  1  0
  8 22  1  1
  9 23  1  0
  9 24  1  0
 10 25  1  0
 10 26  1  0
M  END
Download

3D SDF for HMDB0001451 ((R)-Lipoic acid)

  Mrv1652305261923502D          

 12 12  0  0  0  0            999 V2000
   -0.0308    0.7026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3817   -0.5669    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6982    0.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4433   -0.5669    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6366    0.2177    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3511    0.6302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0656    0.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7801    0.6302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4945    0.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090    0.6302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090    1.4552    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9235    0.2177    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  5  1  1  0  0  0  0
  5  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  4  1  0  0  0  0
  5  6  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 12  1  0  0  0  0
 10 11  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0001451

> <DATABASE_NAME>
hmdb

> <SMILES>
OC(=O)CCCC[C@@H]1CCSS1

> <INCHI_IDENTIFIER>
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

> <INCHI_KEY>
AGBQKNBQESQNJD-SSDOTTSWSA-N

> <FORMULA>
C8H14O2S2

> <MOLECULAR_WEIGHT>
206.326

> <EXACT_MASS>
206.043521072

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
26

> <JCHEM_AVERAGE_POLARIZABILITY>
21.744975428939433

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid

> <ALOGPS_LOGP>
2.75

> <JCHEM_LOGP>
2.1137794076666667

> <ALOGPS_LOGS>
-2.96

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.523468122735193

> <JCHEM_POLAR_SURFACE_AREA>
37.3

> <JCHEM_REFRACTIVITY>
54.3714

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.24e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
lipoic acid

> <JCHEM_VEBER_RULE>
1

$$$$
Download

3D-SDF for HMDB0001451 ((R)-Lipoic acid)

HMDB0001451
     RDKit          3D
(R)-Lipoic acid
 26 26  0  0  0  0  0  0  0  0999 V2000
    3.4270   -0.3763   -1.0240 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3522   -0.5691    0.2013 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -1.2350    0.8430 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2335   -0.1546    1.0445 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1383    0.4575    0.2378 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5748   -0.5409   -0.7426 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5328    0.0606   -1.5689 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6268    0.5141   -0.7002 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.2945   -0.5100    0.1483 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1669    0.2725    1.1411 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4493    0.9129   -0.0203 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0697    1.1240   -1.6813 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.3410   -1.0602    0.4779 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5472    0.5136    1.8822 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8774   -1.0876    1.5763 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4708    1.3925   -0.2858 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3369    0.8126    0.9506 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1907   -1.3998   -0.1283 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2945   -0.9652   -1.4404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8418   -0.5715   -2.4023 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0840    0.9828   -2.0441 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3209    1.3671   -0.0638 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6585   -1.2312    0.6509 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0241   -1.0940   -0.4647 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5354    1.0924    1.5186 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5944   -0.3788    1.8941 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12  8  1  0
  3 13  1  0
  4 14  1  0
  4 15  1  0
  5 16  1  0
  5 17  1  0
  6 18  1  0
  6 19  1  0
  7 20  1  0
  7 21  1  0
  8 22  1  1
  9 23  1  0
  9 24  1  0
 10 25  1  0
 10 26  1  0
M  END
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PDB for HMDB0001451 ((R)-Lipoic acid)

HEADER    PROTEIN                                 26-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-MAY-19         0                                  
HETATM    1  C   UNK     0      -0.057   1.312   0.000  0.00  0.00           C+0
HETATM    2  S   UNK     0       0.713  -1.058   0.000  0.00  0.00           S+0
HETATM    3  C   UNK     0      -1.303   0.406   0.000  0.00  0.00           C+0
HETATM    4  S   UNK     0      -0.827  -1.058   0.000  0.00  0.00           S+0
HETATM    5  C   UNK     0       1.188   0.406   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.522   1.176   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.856   0.406   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       5.190   1.176   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.523   0.406   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.857   1.176   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       7.857   2.716   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0       9.191   0.406   0.000  0.00  0.00           O+0
CONECT    1    5    3                                                       
CONECT    2    5    4                                                       
CONECT    3    1    4                                                       
CONECT    4    2    3                                                       
CONECT    5    1    2    6                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   12   11                                                  
CONECT   11   10                                                            
CONECT   12   10                                                            
MASTER        0    0    0    0    0    0    0    0   12    0   24    0
END
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3D PDB for HMDB0001451 ((R)-Lipoic acid)

COMPND    HMDB0001451
HETATM    1  O1  UNL     1       3.427  -0.376  -1.024  1.00  0.00           O  
HETATM    2  C1  UNL     1       3.352  -0.569   0.201  1.00  0.00           C  
HETATM    3  O2  UNL     1       4.415  -1.235   0.843  1.00  0.00           O  
HETATM    4  C2  UNL     1       2.233  -0.155   1.045  1.00  0.00           C  
HETATM    5  C3  UNL     1       1.138   0.457   0.238  1.00  0.00           C  
HETATM    6  C4  UNL     1       0.575  -0.541  -0.743  1.00  0.00           C  
HETATM    7  C5  UNL     1      -0.533   0.061  -1.569  1.00  0.00           C  
HETATM    8  C6  UNL     1      -1.627   0.514  -0.700  1.00  0.00           C  
HETATM    9  C7  UNL     1      -2.295  -0.510   0.148  1.00  0.00           C  
HETATM   10  C8  UNL     1      -3.167   0.272   1.141  1.00  0.00           C  
HETATM   11  S1  UNL     1      -4.449   0.913  -0.020  1.00  0.00           S  
HETATM   12  S2  UNL     1      -3.070   1.124  -1.681  1.00  0.00           S  
HETATM   13  H1  UNL     1       5.341  -1.060   0.478  1.00  0.00           H  
HETATM   14  H2  UNL     1       2.547   0.514   1.882  1.00  0.00           H  
HETATM   15  H3  UNL     1       1.877  -1.088   1.576  1.00  0.00           H  
HETATM   16  H4  UNL     1       1.471   1.392  -0.286  1.00  0.00           H  
HETATM   17  H5  UNL     1       0.337   0.813   0.951  1.00  0.00           H  
HETATM   18  H6  UNL     1       0.191  -1.400  -0.128  1.00  0.00           H  
HETATM   19  H7  UNL     1       1.295  -0.965  -1.440  1.00  0.00           H  
HETATM   20  H8  UNL     1      -0.842  -0.572  -2.402  1.00  0.00           H  
HETATM   21  H9  UNL     1      -0.084   0.983  -2.044  1.00  0.00           H  
HETATM   22  H10 UNL     1      -1.321   1.367  -0.064  1.00  0.00           H  
HETATM   23  H11 UNL     1      -1.659  -1.231   0.651  1.00  0.00           H  
HETATM   24  H12 UNL     1      -3.024  -1.094  -0.465  1.00  0.00           H  
HETATM   25  H13 UNL     1      -2.535   1.092   1.519  1.00  0.00           H  
HETATM   26  H14 UNL     1      -3.594  -0.379   1.894  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   13
CONECT    4    5   14   15
CONECT    5    6   16   17
CONECT    6    7   18   19
CONECT    7    8   20   21
CONECT    8    9   12   22
CONECT    9   10   23   24
CONECT   10   11   25   26
CONECT   11   12
END
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SMILES for HMDB0001451 ((R)-Lipoic acid)

OC(=O)CCCC[C@@H]1CCSS1
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INCHI for HMDB0001451 ((R)-Lipoic acid)

InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
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View in JSmolView Stereo Labels
Synonyms
Chemical FormulaC8H14O2S2
Average Molecular Weight206.326
Monoisotopic Molecular Weight206.043521072
IUPAC Name5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid
Traditional Namelipoic acid
CAS Registry Number1200-22-2
SMILES
OC(=O)CCCC[C@@H]1CCSS1
InChI Identifier
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChI KeyAGBQKNBQESQNJD-SSDOTTSWSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as lipoic acids and derivatives. Lipoic acids and derivatives are compounds containing a lipoic acid moiety (or a derivative thereof), which consists of a pentanoic acid (or derivative) attached to the C3 carbon atom of a 1,2-dithiolane ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDithiolanes
Sub ClassLipoic acids and derivatives
Direct ParentLipoic acids and derivatives
Alternative Parents
Substituents
  • Lipoic_acid_derivative
  • Medium-chain fatty acid
  • Heterocyclic fatty acid
  • Thia fatty acid
  • Fatty acyl
  • Fatty acid
  • 1,2-dithiolane
  • Organic disulfide
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organic oxide
  • Organic oxygen compound
  • Carbonyl group
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process
Role
Industrial applicationBiological role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point60.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
Biospecimen Locations
  • Blood
  • Urine
Tissue Locations
  • Kidney
  • Liver
  • Neuron
  • Placenta
  • Skeletal Muscle
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.077 +/- 0.017 uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
 details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00166
Phenol Explorer Compound IDNot Available
FooDB IDFDB022631
KNApSAcK IDC00000754
Chemspider ID5886
KEGG Compound IDC16241
BioCyc IDLIPOIC-ACID
BiGG ID35801
Wikipedia LinkLipoic_acid
METLIN ID126
PubChem Compound6112
PDB IDNot Available
ChEBI ID30314
Food Biomarker OntologyNot Available
VMH IDLIPOATE
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References

Enzymes

Enzyme Details
1. Pyruvate dehydrogenase protein X component, mitochondrial
General function:
Involved in acyltransferase activity
Specific function:
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex
Gene Name:
PDHX
Uniprot ID:
O00330
Molecular weight:
54121.8
Enzyme Details
2. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
General function:
Involved in acyltransferase activity
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:
DLAT
Uniprot ID:
P10515
Molecular weight:
68996.03
Enzyme Details
3. NADPH--cytochrome P450 reductase
General function:
Involved in oxidoreductase activity
Specific function:
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Gene Name:
POR
Uniprot ID:
P16435
Molecular weight:
77047.575
Enzyme Details
4. Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
General function:
Involved in acyltransferase activity
Specific function:
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:
DLST
Uniprot ID:
P36957
Molecular weight:
48754.87
Enzyme Details
5. Glycine cleavage system H protein, mitochondrial
General function:
Involved in glycine catabolic process
Specific function:
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Gene Name:
GCSH
Uniprot ID:
P23434
Molecular weight:
Not Available
Enzyme Details
6. Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
General function:
Involved in acyltransferase activity
Specific function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:
DBT
Uniprot ID:
P11182
Molecular weight:
53486.635
Enzyme Details
7. 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
General function:
Involved in catalytic activity
Specific function:
May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
Gene Name:
OXSM
Uniprot ID:
Q9NWU1
Molecular weight:
40034.535
Enzyme Details
8. Lipoyltransferase 1, mitochondrial
General function:
Involved in catalytic activity
Specific function:
Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes (By similarity).
Gene Name:
LIPT1
Uniprot ID:
Q9Y234
Molecular weight:
42478.8