Hmdb loader
Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2021-09-14 15:18:55 UTC
HMDB IDHMDB0001078
Secondary Accession Numbers
  • HMDB01078
Metabolite Identification
Common NameMannose 6-phosphate
DescriptionMannose 6-phosphate, also known as alpha-D-mannose-6-p or man-6-p, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Mannose 6-phosphate exists in all eukaryotes, ranging from yeast to humans. Within humans, mannose 6-phosphate participates in a number of enzymatic reactions. In particular, mannose 6-phosphate can be converted into fructose 6-phosphate through its interaction with the enzyme mannose-6-phosphate isomerase. In addition, mannose 6-phosphate can be biosynthesized from D-mannose through the action of the enzyme hexokinase-1. Mannose 6-phosphate is a potent competitive inhibitor of pinocytosis of human platelet beta-glucuronidase and it is a necessary component of the recognition marker on the enzyme for pinocytosis by human fibroblasts as well (PMID 908752 ). In humans, mannose 6-phosphate is involved in fructose intolerance, hereditary.
Structure
Data?1582752175
Synonyms
ValueSource
Mannose 6-phosphoric acidGenerator
alpha-D-Mannose-6-pHMDB
alpha-D-Mannose-6-phosphateHMDB
alpha-delta-Mannose-6-pHMDB
alpha-delta-Mannose-6-phosphateHMDB
D-Mannose 6-phosphateHMDB
delta-Mannose 6-phosphateHMDB
Man-6-pHMDB
Mannose-6-phosphateHMDB
Mannose-6-phosphate dilithium saltHMDB
Mannose-6-phosphate disodium saltHMDB
Mannose-6-phosphate sodium salt, (D)-isomerHMDB
Chemical FormulaC6H13O9P
Average Molecular Weight260.1358
Monoisotopic Molecular Weight260.029718526
IUPAC Name{[(2R,3S,4S,5S,6R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid
Traditional Namemannose 6 phosphate
CAS Registry Number3672-15-9
SMILES
O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O
InChI Identifier
InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6-/m1/s1
InChI KeyNBSCHQHZLSJFNQ-RWOPYEJCSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentHexose phosphates
Alternative Parents
Substituents
  • Hexose phosphate
  • Monosaccharide phosphate
  • Monoalkyl phosphate
  • Organic phosphoric acid derivative
  • Alkyl phosphate
  • Oxane
  • Phosphoric acid ester
  • Hemiacetal
  • Secondary alcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Polyol
  • Hydrocarbon derivative
  • Alcohol
  • Organic oxide
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available143.473http://allccs.zhulab.cn/database/detail?ID=AllCCS00000385
Predicted Molecular Properties
PropertyValueSource
Water Solubility31.4 g/LALOGPS
logP-2.1ALOGPS
logP-3.1ChemAxon
logS-0.92ALOGPS
pKa (Strongest Acidic)1.22ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area156.91 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity46.8 m³·mol⁻¹ChemAxon
Polarizability20.99 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+153.67631661259
DarkChem[M-H]-149.80531661259
AllCCS[M+H]+156.31632859911
AllCCS[M-H]-147.16332859911
DeepCCS[M+H]+143.58430932474
DeepCCS[M-H]-141.18930932474
DeepCCS[M-2H]-175.7730932474
DeepCCS[M+Na]+150.20830932474
AllCCS[M+H]+156.332859911
AllCCS[M+H-H2O]+152.832859911
AllCCS[M+NH4]+159.632859911
AllCCS[M+Na]+160.532859911
AllCCS[M-H]-147.232859911
AllCCS[M+Na-2H]-147.532859911
AllCCS[M+HCOO]-147.932859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Mannose 6-phosphateO[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O3490.8Standard polar33892256
Mannose 6-phosphateO[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O2068.8Standard non polar33892256
Mannose 6-phosphateO[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O2270.1Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Mannose 6-phosphate,1TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O)[C@@H]1O2119.1Semi standard non polar33892256
Mannose 6-phosphate,1TMS,isomer #2C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O)O[C@@H](O)[C@@H](O)[C@H]1O2099.4Semi standard non polar33892256
Mannose 6-phosphate,1TMS,isomer #3C[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O)[C@H]1O2103.7Semi standard non polar33892256
Mannose 6-phosphate,1TMS,isomer #4C[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O[C@H]1O2111.9Semi standard non polar33892256
Mannose 6-phosphate,1TMS,isomer #5C[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O2258.3Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O2073.3Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #10C[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O[C@H]1O2221.4Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #11C[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O)O[Si](C)(C)C2262.3Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #2C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O2088.7Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #3C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O)[C@@H]1O[Si](C)(C)C2065.5Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #4C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O2208.5Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #5C[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O[C@H]1O2082.7Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #6C[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O)[C@H]1O[Si](C)(C)C2066.5Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #7C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O[Si](C)(C)C)O[C@@H](O)[C@@H](O)[C@H]1O2194.6Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #8C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H](COP(=O)(O)O)O[C@H]1O2080.6Semi standard non polar33892256
Mannose 6-phosphate,2TMS,isomer #9C[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@H]1O2207.1Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O2106.4Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #10C[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@H]1O[Si](C)(C)C2140.4Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #11C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@@H](O)[C@@H](O)[C@H]1O2175.7Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #12C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O[C@H]1O2178.2Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #13C[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@H]1O2169.0Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #14C[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1O2199.4Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #2C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C2104.9Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #3C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O2139.8Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #4C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2110.2Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #5C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O2165.8Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #6C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O[Si](C)(C)C2128.6Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #7C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O2161.1Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #8C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O[C@H]1O2125.4Semi standard non polar33892256
Mannose 6-phosphate,3TMS,isomer #9C[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O[C@H]1O2193.8Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2129.8Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #10C[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@H]1O[Si](C)(C)C2199.4Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #11C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1O2243.0Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #2C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O2204.3Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #3C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C2201.8Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #4C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O2193.7Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #5C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2205.6Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #6C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O2223.7Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #7C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O[Si](C)(C)C2182.9Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #8C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O[C@H]1O2217.3Semi standard non polar33892256
Mannose 6-phosphate,4TMS,isomer #9C[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1O2260.4Semi standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2216.9Semi standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2232.2Standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2598.4Standard polar33892256
Mannose 6-phosphate,5TMS,isomer #2C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O2241.3Semi standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #2C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O2261.9Standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #2C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O2478.6Standard polar33892256
Mannose 6-phosphate,5TMS,isomer #3C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C2236.9Semi standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #3C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C2263.5Standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #3C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C2465.6Standard polar33892256
Mannose 6-phosphate,5TMS,isomer #4C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2240.2Semi standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #4C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2262.3Standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #4C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2508.1Standard polar33892256
Mannose 6-phosphate,5TMS,isomer #5C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1O2255.9Semi standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #5C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1O2252.6Standard non polar33892256
Mannose 6-phosphate,5TMS,isomer #5C[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1O2475.9Standard polar33892256
Mannose 6-phosphate,6TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2260.7Semi standard non polar33892256
Mannose 6-phosphate,6TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2286.5Standard non polar33892256
Mannose 6-phosphate,6TMS,isomer #1C[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2423.5Standard polar33892256
Mannose 6-phosphate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O)[C@@H]1O2369.9Semi standard non polar33892256
Mannose 6-phosphate,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O)O[C@@H](O)[C@@H](O)[C@H]1O2381.0Semi standard non polar33892256
Mannose 6-phosphate,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O)[C@H]1O2384.4Semi standard non polar33892256
Mannose 6-phosphate,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O[C@H]1O2398.5Semi standard non polar33892256
Mannose 6-phosphate,1TBDMS,isomer #5CC(C)(C)[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O2514.5Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O2510.5Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #10CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[C@H]1O2688.1Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #11CC(C)(C)[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O)O[Si](C)(C)C(C)(C)C2744.4Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O2514.9Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C2508.1Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O2637.7Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O[C@H]1O2545.2Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O)[C@H]1O[Si](C)(C)C(C)(C)C2523.9Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[C@@H](O)[C@@H](O)[C@H]1O2666.7Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H](COP(=O)(O)O)O[C@H]1O2531.9Semi standard non polar33892256
Mannose 6-phosphate,2TBDMS,isomer #9CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@H]1O2662.8Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O2738.2Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C2809.1Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #11CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@@H](O)[C@@H](O)[C@H]1O2857.4Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #12CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[C@H]1O2821.0Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #13CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]1O2844.6Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #14CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H]1O2872.3Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C2734.5Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O2788.5Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C2749.5Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O2784.5Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C2782.3Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O2827.3Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O[C@H]1O2773.8Semi standard non polar33892256
Mannose 6-phosphate,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[C@H]1O2835.6Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C2982.8Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #10CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@H](O)O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C3022.7Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #11CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H]1O3041.3Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O2994.1Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C3001.9Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O3006.4Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3003.0Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O3012.4Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C3000.1Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[C@H]1O3039.4Semi standard non polar33892256
Mannose 6-phosphate,4TBDMS,isomer #9CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H]1O3064.3Semi standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3237.9Semi standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3130.3Standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3025.3Standard polar33892256
Mannose 6-phosphate,5TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O3222.9Semi standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O3123.2Standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O2948.2Standard polar33892256
Mannose 6-phosphate,5TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C3231.3Semi standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C3134.3Standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C2933.8Standard polar33892256
Mannose 6-phosphate,5TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3229.6Semi standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3116.4Standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C2968.2Standard polar33892256
Mannose 6-phosphate,5TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H]1O3259.2Semi standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H]1O3134.6Standard non polar33892256
Mannose 6-phosphate,5TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H]1O2945.0Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Mannose 6-phosphate GC-MS (Non-derivatized) - 70eV, Positivesplash10-0005-9740000000-a6e81224fb97751dc2e62016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Mannose 6-phosphate GC-MS (4 TMS) - 70eV, Positivesplash10-001i-2533590000-b6a62e882bfffed3184a2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Mannose 6-phosphate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Mannose 6-phosphate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Mannose 6-phosphate Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-0007-3490000000-734a88a9b3fd55b3e43f2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mannose 6-phosphate Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-052b-9300000000-2c63b28f70b6b2eb75a12012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mannose 6-phosphate Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-00l2-9000000000-5406aea843f73d03563c2012-07-24HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 10V, Positive-QTOFsplash10-03di-0490000000-94ea79ec673f4688b7a02016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 20V, Positive-QTOFsplash10-03dm-5940000000-c649262446626dcb8d6e2016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 40V, Positive-QTOFsplash10-0uka-9800000000-aae2cb792906d2dec6cd2016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 10V, Negative-QTOFsplash10-0a6r-8290000000-8e20219f94b3fe964e382016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 20V, Negative-QTOFsplash10-004i-9000000000-b19b64f5cb4124047baf2016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 40V, Negative-QTOFsplash10-004i-9000000000-ecb75a44e3d25affdf312016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 10V, Negative-QTOFsplash10-0a6s-9060000000-b446300429049a22bea42021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 20V, Negative-QTOFsplash10-004i-9000000000-d5aaca13a836cb9f17252021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 40V, Negative-QTOFsplash10-004i-9000000000-a5e502a2627af2048a1f2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 10V, Positive-QTOFsplash10-03dm-0970000000-40dbaf3d3c72cf65bf472021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 20V, Positive-QTOFsplash10-01ot-7900000000-00bc03290b6c0bfb7f842021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mannose 6-phosphate 40V, Positive-QTOFsplash10-000t-9000000000-7a6ff6606f1dbc2f0ae42021-09-25Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, H2O, predicted)2022-08-20Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)2012-12-05Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen Locations
  • Feces
Tissue Locations
  • Fibroblasts
  • Intestine
  • Liver
  • Prostate
  • Spleen
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
Associated Disorders and Diseases
Disease References
Colorectal cancer
  1. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022411
KNApSAcK IDNot Available
Chemspider ID388338
KEGG Compound IDC00275
BioCyc IDNot Available
BiGG ID34471
Wikipedia LinkMannose 6-phosphate
METLIN ID5987
PubChem Compound439198
PDB IDNot Available
ChEBI ID49728
Food Biomarker OntologyNot Available
VMH IDMAN6P
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferencePascual, C.; Herrera, L. Use of permeabilized yeast cells as a system of enzyme immobilization. Its use for the preparation of mannose 6-phosphate. Folia Microbiologica (Prague, Czech Republic) (1981), 26(2), 103-6.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Tiede S, Muschol N, Reutter G, Cantz M, Ullrich K, Braulke T: Missense mutations in N-acetylglucosamine-1-phosphotransferase alpha/beta subunit gene in a patient with mucolipidosis III and a mild clinical phenotype. Am J Med Genet A. 2005 Sep 1;137A(3):235-40. [PubMed:16094673 ]
  2. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
  3. DeRossi C, Bode L, Eklund EA, Zhang F, Davis JA, Westphal V, Wang L, Borowsky AD, Freeze HH: Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. J Biol Chem. 2006 Mar 3;281(9):5916-27. Epub 2005 Dec 8. [PubMed:16339137 ]
  4. Beljaars L, Molema G, Weert B, Bonnema H, Olinga P, Groothuis GM, Meijer DK, Poelstra K: Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells. Hepatology. 1999 May;29(5):1486-93. [PubMed:10216133 ]
  5. van der Ploeg AT, van der Kraaij AM, Willemsen R, Kroos MA, Loonen MC, Koster JF, Reuser AJ: Rat heart perfusion as model system for enzyme replacement therapy in glycogenosis type II. Pediatr Res. 1990 Oct;28(4):344-7. [PubMed:2235132 ]
  6. Yatziv S, Barfi G, Newburg DS: Lysosomal hydrolases in blood-derived macrophages of patients with I-cell disease. J Lab Clin Med. 1986 Oct;108(4):365-8. [PubMed:3093618 ]
  7. Puolakkainen M, Kuo CC, Campbell LA: Chlamydia pneumoniae uses the mannose 6-phosphate/insulin-like growth factor 2 receptor for infection of endothelial cells. Infect Immun. 2005 Aug;73(8):4620-5. [PubMed:16040974 ]
  8. Holtta-Vuori M, Maatta J, Ullrich O, Kuismanen E, Ikonen E: Mobilization of late-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor. Curr Biol. 2000 Jan 27;10(2):95-8. [PubMed:10662671 ]
  9. Harper J, Burns JL, Foulstone EJ, Pignatelli M, Zaina S, Hassan AB: Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. Cancer Res. 2006 Feb 15;66(4):1940-8. [PubMed:16488992 ]
  10. Saris JJ, Derkx FH, De Bruin RJ, Dekkers DH, Lamers JM, Saxena PR, Schalekamp MA, Jan Danser AH: High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1706-15. [PubMed:11247783 ]
  11. Bird CH, Sun J, Ung K, Karambalis D, Whisstock JC, Trapani JA, Bird PI: Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol. 2005 Sep;25(17):7854-67. [PubMed:16107729 ]
  12. Adrian JE, Poelstra K, Scherphof GL, Molema G, Meijer DK, Reker-Smit C, Morselt HW, Kamps JA: Interaction of targeted liposomes with primary cultured hepatic stellate cells: Involvement of multiple receptor systems. J Hepatol. 2006 Mar;44(3):560-7. Epub 2005 Oct 19. [PubMed:16368158 ]
  13. Ullrich K, Basner R, Gieselmann V, Von Figura K: Recognition of human urine alpha-N-acetylglucosaminidase by rat hepatocytes. Involvement of receptors specific for galactose, mannose 6-phosphate and mannose. Biochem J. 1979 May 15;180(2):413-9. [PubMed:114170 ]
  14. Davis JA, Wu XH, Wang L, DeRossi C, Westphal V, Wu R, Alton G, Srikrishna G, Freeze HH: Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase. Glycobiology. 2002 Jul;12(7):435-42. [PubMed:12122025 ]
  15. Kaplan A, Fischer D, Achord D, Sly W: Phosphohexosyl recognition is a general characteristic of pinocytosis of lysosomal glycosidases by human fibroblasts. J Clin Invest. 1977 Nov;60(5):1088-93. [PubMed:908752 ]
  16. Lobel P, Dahms NM, Breitmeyer J, Chirgwin JM, Kornfeld S: Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2233-7. [PubMed:2951738 ]
  17. Maguchi S, Taniguchi N, Makita A: Elevated activity and increased mannose-6-phosphate in the carbohydrate moiety of cathepsin D from human hepatoma. Cancer Res. 1988 Jan 15;48(2):362-7. [PubMed:2825973 ]
  18. Sleat DE, Wang Y, Sohar I, Lackland H, Li Y, Li H, Zheng H, Lobel P: Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteins. Mol Cell Proteomics. 2006 Oct;5(10):1942-56. Epub 2006 May 17. [PubMed:16709564 ]
  19. Sleat DE, Sohar I, Lackland H, Majercak J, Lobel P: Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. J Biol Chem. 1996 Aug 9;271(32):19191-8. [PubMed:8702598 ]

Only showing the first 10 proteins. There are 16 proteins in total.

Enzymes

General function:
Involved in ATP binding
Specific function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Gene Name:
GCK
Uniprot ID:
P35557
Molecular weight:
52191.07
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK3
Uniprot ID:
P52790
Molecular weight:
99024.56
Reactions
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK2
Uniprot ID:
P52789
Molecular weight:
102379.06
Reactions
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK1
Uniprot ID:
P19367
Molecular weight:
102485.1
Reactions
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
General function:
Involved in mannose-6-phosphate isomerase activity
Specific function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Gene Name:
MPI
Uniprot ID:
P34949
Molecular weight:
46655.44
Reactions
Mannose 6-phosphate → Fructose 6-phosphatedetails
Mannose 6-phosphate → Beta-D-Fructose 6-phosphatedetails
General function:
Involved in catalytic activity
Specific function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity).
Gene Name:
PMM2
Uniprot ID:
O15305
Molecular weight:
28081.925
Reactions
D-Mannose 1-phosphate → Mannose 6-phosphatedetails
Mannose 6-phosphate → D-Mannose 1-phosphatedetails
General function:
Involved in metal ion binding
Specific function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
Gene Name:
PMM1
Uniprot ID:
Q92871
Molecular weight:
29746.545
Reactions
D-Mannose 1-phosphate → Mannose 6-phosphatedetails
Mannose 6-phosphate → D-Mannose 1-phosphatedetails
General function:
Involved in protein binding
Specific function:
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network
Gene Name:
PLIN3
Uniprot ID:
O60664
Molecular weight:
47046.6
General function:
Involved in protein binding
Specific function:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex
Gene Name:
M6PR
Uniprot ID:
P20645
Molecular weight:
30993.1
General function:
Involved in transporter activity
Specific function:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4
Gene Name:
IGF2R
Uniprot ID:
P11717
Molecular weight:
274273.3

Only showing the first 10 proteins. There are 16 proteins in total.