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Showing metabocard for Histamine (HMDB0000870)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-05-30 20:55:48 UTC
HMDB IDHMDB0000870
Secondary Accession Numbers
  • HMDB0060263
  • HMDB00870
  • HMDB60263
Metabolite Identification
Common NameHistamine
DescriptionHistamine is an amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Histamine can be found in Photobacterium phosphoreum and Lactobacillus (PMID:17066936 ). Histamine belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group. High amounts of histamine have been found in spinach, oats and ryes. Another foods such as green beans, broccoli, and beetroots also contain histamine but in lower concentrations. Histamine has also been detected but not quantified in several different foods, such as groundcherries, carobs, bok choy, biscuits, and longans.
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000870 (Histamine)

  Mrv1652309042000132D          

  8  8  0  0  0  0            999 V2000
10000.301210000.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.016010000.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.728710000.5262    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.915610000.6081    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.248210000.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5031 9999.3385    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3281 9999.3385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.583010000.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  7  8  2  0  0  0  0
  4  5  2  0  0  0  0
  4  8  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  1  8  1  0  0  0  0
M  END
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3D MOL for HMDB0000870 (Histamine)

HMDB0000870
     RDKit          3D
Histamine
 17 17  0  0  0  0  0  0  0  0999 V2000
   -2.9568   -0.4732   -0.3723 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5252   -0.6604   -0.3978 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8874    0.6814   -0.1322 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6031    0.5068   -0.1549 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -0.6449   -0.3735 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6061   -0.3157   -0.2997 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7572    0.9939   -0.0439 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5137    1.4928    0.0437 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4195   -1.0322    0.3628 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2418    0.5204   -0.2408 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1874   -1.4115    0.3436 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1587   -1.0044   -1.3875 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1475    1.3595   -0.9559 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2225    1.1453    0.8016 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8595   -1.6177   -0.5660 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3764   -1.0199   -0.4308 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7190    1.4799    0.0578 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  4  1  0
  1  9  1  0
  1 10  1  0
  2 11  1  0
  2 12  1  0
  3 13  1  0
  3 14  1  0
  5 15  1  0
  6 16  1  0
  7 17  1  0
M  END
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3D SDF for HMDB0000870 (Histamine)

  Mrv1652309042000132D          

  8  8  0  0  0  0            999 V2000
10000.301210000.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.016010000.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.728710000.5262    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.915610000.6081    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.248210000.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5031 9999.3385    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3281 9999.3385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.583010000.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  7  8  2  0  0  0  0
  4  5  2  0  0  0  0
  4  8  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  1  8  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000870

> <DATABASE_NAME>
hmdb

> <SMILES>
NCCC1=CNC=N1

> <INCHI_IDENTIFIER>
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

> <INCHI_KEY>
NTYJJOPFIAHURM-UHFFFAOYSA-N

> <FORMULA>
C5H9N3

> <MOLECULAR_WEIGHT>
111.1451

> <EXACT_MASS>
111.079647303

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
17

> <JCHEM_AVERAGE_POLARIZABILITY>
12.083995477047418

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-(1H-imidazol-4-yl)ethan-1-amine

> <ALOGPS_LOGP>
-0.69

> <JCHEM_LOGP>
-0.7009711443333334

> <ALOGPS_LOGS>
0.18

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.456615295256658

> <JCHEM_PKA_STRONGEST_BASIC>
9.576453109401491

> <JCHEM_POLAR_SURFACE_AREA>
54.7

> <JCHEM_REFRACTIVITY>
31.663399999999996

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.69e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
histamine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0000870 (Histamine)

HMDB0000870
     RDKit          3D
Histamine
 17 17  0  0  0  0  0  0  0  0999 V2000
   -2.9568   -0.4732   -0.3723 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5252   -0.6604   -0.3978 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8874    0.6814   -0.1322 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6031    0.5068   -0.1549 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -0.6449   -0.3735 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6061   -0.3157   -0.2997 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7572    0.9939   -0.0439 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5137    1.4928    0.0437 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4195   -1.0322    0.3628 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2418    0.5204   -0.2408 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1874   -1.4115    0.3436 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1587   -1.0044   -1.3875 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1475    1.3595   -0.9559 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2225    1.1453    0.8016 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8595   -1.6177   -0.5660 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3764   -1.0199   -0.4308 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7190    1.4799    0.0578 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  4  1  0
  1  9  1  0
  1 10  1  0
  2 11  1  0
  2 12  1  0
  3 13  1  0
  3 14  1  0
  5 15  1  0
  6 16  1  0
  7 17  1  0
M  END
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PDB for HMDB0000870 (Histamine)

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0    8667.2298667.649   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8668.5638666.880   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0    8669.8948667.649   0.000  0.00  0.00           N+0
HETATM    4  N   UNK     0    8664.6428667.802   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0    8663.3978666.896   0.000  0.00  0.00           C+0
HETATM    6  N   UNK     0    8663.8728665.432   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0    8665.4128665.432   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8665.8888666.896   0.000  0.00  0.00           C+0
CONECT    1    2    8                                                       
CONECT    2    1    3                                                       
CONECT    3    2                                                            
CONECT    4    5    8                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    8    6                                                       
CONECT    8    7    4    1                                                  
MASTER        0    0    0    0    0    0    0    0    8    0   16    0
END
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3D PDB for HMDB0000870 (Histamine)

COMPND    HMDB0000870
HETATM    1  N1  UNL     1      -2.957  -0.473  -0.372  1.00  0.00           N  
HETATM    2  C1  UNL     1      -1.525  -0.660  -0.398  1.00  0.00           C  
HETATM    3  C2  UNL     1      -0.887   0.681  -0.132  1.00  0.00           C  
HETATM    4  C3  UNL     1       0.603   0.507  -0.155  1.00  0.00           C  
HETATM    5  C4  UNL     1       1.312  -0.645  -0.373  1.00  0.00           C  
HETATM    6  N2  UNL     1       2.606  -0.316  -0.300  1.00  0.00           N  
HETATM    7  C5  UNL     1       2.757   0.994  -0.044  1.00  0.00           C  
HETATM    8  N3  UNL     1       1.514   1.493   0.044  1.00  0.00           N  
HETATM    9  H1  UNL     1      -3.419  -1.032   0.363  1.00  0.00           H  
HETATM   10  H2  UNL     1      -3.242   0.520  -0.241  1.00  0.00           H  
HETATM   11  H3  UNL     1      -1.187  -1.411   0.344  1.00  0.00           H  
HETATM   12  H4  UNL     1      -1.159  -1.004  -1.388  1.00  0.00           H  
HETATM   13  H5  UNL     1      -1.147   1.359  -0.956  1.00  0.00           H  
HETATM   14  H6  UNL     1      -1.222   1.145   0.802  1.00  0.00           H  
HETATM   15  H7  UNL     1       0.860  -1.618  -0.566  1.00  0.00           H  
HETATM   16  H8  UNL     1       3.376  -1.020  -0.431  1.00  0.00           H  
HETATM   17  H9  UNL     1       3.719   1.480   0.058  1.00  0.00           H  
CONECT    1    2    9   10
CONECT    2    3   11   12
CONECT    3    4   13   14
CONECT    4    5    5    8
CONECT    5    6   15
CONECT    6    7   16
CONECT    7    8    8   17
END
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SMILES for HMDB0000870 (Histamine)

NCCC1=CNC=N1
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INCHI for HMDB0000870 (Histamine)

InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC5H9N3
Average Molecular Weight111.1451
Monoisotopic Molecular Weight111.079647303
IUPAC Name2-(1H-imidazol-4-yl)ethan-1-amine
Traditional Namehistamine
CAS Registry Number51-45-6
SMILES
NCCC1=CNC=N1
InChI Identifier
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChI KeyNTYJJOPFIAHURM-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct Parent2-arylethylamines
Alternative Parents
Substituents
  • 2-arylethylamine
  • Aralkylamine
  • Heteroaromatic compound
  • Imidazole
  • Azole
  • Azacycle
  • Organoheterocyclic compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Primary aliphatic amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process
Role
Biological roleIndustrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point86 °CNot Available
Boiling Point380.29 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility1000000 mg/L @ 25 °C (est)The Good Scents Company Information System
LogP-0.70SANGSTER (1993)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+MetCCS_train_pos120.01330932474
[M+H]+Not Available120.4http://allccs.zhulab.cn/database/detail?ID=AllCCS00000534
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Extracellular
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Saliva
  • Urine
Tissue Locations
  • Adipose Tissue
  • Adrenal Medulla
  • Bladder
  • Brain
  • Epidermis
  • Fibroblasts
  • Intestine
  • Kidney
  • Neuron
  • Pancreas
  • Placenta
  • Platelet
  • Prostate
  • Skeletal Muscle
  • Spleen
  • Testis
Pathways
Normal Concentrations
Abnormal Concentrations
Associated Disorders and Diseases
Disease References
Nephrotic syndrome
  1. Gill DS, Fonseca VA, Barradas MA, Balliod R, Moorhead JF, Dandona P: Plasma histamine in patients with chronic renal failure and nephrotic syndrome. J Clin Pathol. 1991 Mar;44(3):243-5. [PubMed:2013627 ]
Hemodialysis
  1. Gill DS, Fonseca VA, Barradas MA, Balliod R, Moorhead JF, Dandona P: Plasma histamine in patients with chronic renal failure and nephrotic syndrome. J Clin Pathol. 1991 Mar;44(3):243-5. [PubMed:2013627 ]
Kidney disease
  1. Gill DS, Fonseca VA, Barradas MA, Balliod R, Moorhead JF, Dandona P: Plasma histamine in patients with chronic renal failure and nephrotic syndrome. J Clin Pathol. 1991 Mar;44(3):243-5. [PubMed:2013627 ]
Continuous ambulatory peritoneal dialysis
  1. Gill DS, Fonseca VA, Barradas MA, Balliod R, Moorhead JF, Dandona P: Plasma histamine in patients with chronic renal failure and nephrotic syndrome. J Clin Pathol. 1991 Mar;44(3):243-5. [PubMed:2013627 ]
Colorectal cancer
  1. Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ]
  2. Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
  3. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Eosinophilic esophagitis
  1. Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
Associated OMIM IDs
DrugBank IDDB05381
Phenol Explorer Compound IDNot Available
FooDB IDFDB012596
KNApSAcK IDC00001414
Chemspider ID753
KEGG Compound IDC00388
BioCyc IDHISTAMINE
BiGG ID1810403
Wikipedia LinkHistamine
METLIN ID68
PubChem Compound774
PDB IDNot Available
ChEBI ID18295
Food Biomarker OntologyNot Available
VMH IDHISTA
MarkerDB IDMDB00000271
Good Scents IDrw1250321
References
Synthesis ReferencePyman, Frank L. 2-Thiol-4(5)-b-aminoethylglyoxaline (2-thiolhistamine). Journal of the Chemical Society (1930), 98-100.
Material Safety Data Sheet (MSDS)Not Available
General References

Only showing the first 10 proteins. There are 11 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Aromatic-L-amino-acid decarboxylase
General function:
Involved in carboxy-lyase activity
Specific function:
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Gene Name:
DDC
Uniprot ID:
P20711
Molecular weight:
53893.755
Reactions
Histidine → Histamine + Carbon dioxidedetails
Enzyme Details
2. Amiloride-sensitive amine oxidase [copper-containing]
General function:
Involved in copper ion binding
Specific function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
Gene Name:
ABP1
Uniprot ID:
P19801
Molecular weight:
85377.1
Reactions
Histamine + Water + Oxygen → Imidazole-4-acetaldehyde + Ammonia + Hydrogen peroxidedetails
Enzyme Details
3. Retina-specific copper amine oxidase
General function:
Involved in copper ion binding
Specific function:
Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina.
Gene Name:
AOC2
Uniprot ID:
O75106
Molecular weight:
80515.11
Enzyme Details
4. Histamine N-methyltransferase
General function:
Involved in histamine N-methyltransferase activity
Specific function:
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Gene Name:
HNMT
Uniprot ID:
P50135
Molecular weight:
6045.9
Reactions
S-Adenosylmethionine + Histamine → S-Adenosylhomocysteine + 1-Methylhistaminedetails
Enzyme Details
5. Histidine decarboxylase
General function:
Involved in carboxy-lyase activity
Specific function:
Catalyzes the biosynthesis of histamine from histidine.
Gene Name:
HDC
Uniprot ID:
P19113
Molecular weight:
74139.825
Reactions
Histidine → Histamine + CO(2)details
Histidine → Histamine + Carbon dioxidedetails
Enzyme Details
6. Histamine H2 receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway
Gene Name:
HRH2
Uniprot ID:
P25021
Molecular weight:
40097.7
Enzyme Details
7. Synaptic vesicular amine transporter
General function:
Involved in transmembrane transport
Specific function:
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis
Gene Name:
SLC18A2
Uniprot ID:
Q05940
Molecular weight:
55712.1
Enzyme Details
8. Histamine H3 receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization
Gene Name:
HRH3
Uniprot ID:
Q9Y5N1
Molecular weight:
48670.8
Enzyme Details
9. Histamine H1 receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular weight:
55783.6
Enzyme Details
10. Histamine H4 receptor
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist)
Gene Name:
HRH4
Uniprot ID:
Q9H3N8
Molecular weight:
44495.4

Only showing the first 10 proteins. There are 11 proteins in total.

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