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Showing metabocard for Sorbitol (HMDB0000247)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:14:39 UTC
HMDB IDHMDB0000247
Secondary Accession Numbers
  • HMDB00247
Metabolite Identification
Common NameSorbitol
DescriptionSorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications. Ascorbic acid fermentation; in solution form for moisture-conditioning of cosmetic creams and lotions, toothpaste, tobacco, gelatin; bodying agent for paper, textiles, and liquid pharmaceuticals; softener for candy; sugar crystallization inhibitor; surfactants; urethane resins and rigid foams; plasticizer, stabilizer for vinyl resins; food additive (sweetener, humectant, emulsifier, thickener, anticaking agent); dietary supplement. (Hawley's Condensed Chemical Dictionary) Biological Source: Occurs widely in plants ranging from algae to the higher orders. Fruits of the plant family Rosaceae, which include apples, pears, cherries, apricots, contain appreciable amounts. Rich sources are the fruits of the Sorbus and Crataegus species Use/Importance: Used for manufacturing of sorbose, propylene glycol, ascorbic acid, resins, plasticizers and as antifreeze mixtures with glycerol or glycol. Tablet diluent, sweetening agent and humectant, other food uses. Sorbitol is used in photometric determination of Ru(VI) and Ru(VIII); in acid-base titration of borate (Dictionary of Organic Compounds).
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000247 (Sorbitol)

  Mrv1652309032023582D          

 12 11  0  0  1  0            999 V2000
    1.0461    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    1.4289    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4750    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    1.8414    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.1895    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039    1.4289    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.9039    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184    1.8414    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.6184    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  1  0  0  0
  3  5  1  0  0  0  0
  5  6  1  1  0  0  0
  5  7  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
M  END
Download

3D MOL for HMDB0000247 (Sorbitol)

HMDB0000247
     RDKit          3D
Sorbitol
 26 25  0  0  0  0  0  0  0  0999 V2000
   -1.7573    1.9415   -0.1547 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5605    0.8462    0.1243 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9951   -0.4560   -0.3719 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.9253   -1.4582   -0.0135 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7000   -0.8465    0.2674 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3747   -2.1170   -0.2682 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4434    0.0570   -0.1369 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5571    0.1160   -1.5248 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7769   -0.5023    0.3627 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8167   -0.6197    1.7292 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.4210   -0.1645 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7443    1.6977    0.3707 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3130    2.7458   -0.3098 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5184    1.0074   -0.4136 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8222    0.8028    1.2026 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9170   -0.4231   -1.4605 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7279   -1.7041    0.9454 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7839   -0.9544    1.3474 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6288   -2.0753   -1.2248 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3686    1.0811    0.2600 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9283   -0.7481   -1.8334 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9701   -1.5035   -0.0767 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2896    0.0565    2.2138 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8778   -0.0219    0.0152 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7583    0.5185   -1.2632 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6162    2.1384    0.3780 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  6
  4 17  1  0
  5 18  1  1
  6 19  1  0
  7 20  1  1
  8 21  1  0
  9 22  1  6
 10 23  1  0
 11 24  1  0
 11 25  1  0
 12 26  1  0
M  END
Download

3D SDF for HMDB0000247 (Sorbitol)

  Mrv1652309032023582D          

 12 11  0  0  1  0            999 V2000
    1.0461    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    1.4289    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4750    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    1.8414    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.1895    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039    1.4289    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.9039    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184    1.8414    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.6184    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  1  0  0  0
  3  5  1  0  0  0  0
  5  6  1  1  0  0  0
  5  7  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000247

> <DATABASE_NAME>
hmdb

> <SMILES>
OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

> <INCHI_IDENTIFIER>
InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

> <INCHI_KEY>
FBPFZTCFMRRESA-JGWLITMVSA-N

> <FORMULA>
C6H14O6

> <MOLECULAR_WEIGHT>
182.1718

> <EXACT_MASS>
182.07903818

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
26

> <JCHEM_AVERAGE_POLARIZABILITY>
17.12411136029489

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol

> <ALOGPS_LOGP>
-2.68

> <JCHEM_LOGP>
-3.7300188486666666

> <ALOGPS_LOGS>
0.10

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.37874915684328

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.585200956788803

> <JCHEM_PKA_STRONGEST_BASIC>
-2.974211614825128

> <JCHEM_POLAR_SURFACE_AREA>
121.38000000000001

> <JCHEM_REFRACTIVITY>
38.4036

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.29e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
D-sorbitol

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0000247 (Sorbitol)

HMDB0000247
     RDKit          3D
Sorbitol
 26 25  0  0  0  0  0  0  0  0999 V2000
   -1.7573    1.9415   -0.1547 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5605    0.8462    0.1243 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9951   -0.4560   -0.3719 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.9253   -1.4582   -0.0135 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7000   -0.8465    0.2674 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3747   -2.1170   -0.2682 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4434    0.0570   -0.1369 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5571    0.1160   -1.5248 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7769   -0.5023    0.3627 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8167   -0.6197    1.7292 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.4210   -0.1645 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7443    1.6977    0.3707 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3130    2.7458   -0.3098 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5184    1.0074   -0.4136 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8222    0.8028    1.2026 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9170   -0.4231   -1.4605 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7279   -1.7041    0.9454 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7839   -0.9544    1.3474 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6288   -2.0753   -1.2248 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3686    1.0811    0.2600 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9283   -0.7481   -1.8334 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9701   -1.5035   -0.0767 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2896    0.0565    2.2138 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8778   -0.0219    0.0152 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7583    0.5185   -1.2632 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6162    2.1384    0.3780 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  6
  4 17  1  0
  5 18  1  1
  6 19  1  0
  7 20  1  1
  8 21  1  0
  9 22  1  6
 10 23  1  0
 11 24  1  0
 11 25  1  0
 12 26  1  0
M  END
Download

PDB for HMDB0000247 (Sorbitol)

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  O   UNK     0       1.953   2.667   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       3.286   3.437   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.620   2.667   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       4.620   1.127   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       5.954   3.437   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       5.954   4.977   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       7.287   2.667   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       7.287   1.127   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       8.621   3.437   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       8.621   4.977   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       9.955   2.667   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0      11.288   3.437   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12                                                       
CONECT   12   11                                                            
MASTER        0    0    0    0    0    0    0    0   12    0   22    0
END
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3D PDB for HMDB0000247 (Sorbitol)

COMPND    HMDB0000247
HETATM    1  O1  UNL     1      -1.757   1.942  -0.155  1.00  0.00           O  
HETATM    2  C1  UNL     1      -2.561   0.846   0.124  1.00  0.00           C  
HETATM    3  C2  UNL     1      -1.995  -0.456  -0.372  1.00  0.00           C  
HETATM    4  O2  UNL     1      -2.925  -1.458  -0.014  1.00  0.00           O  
HETATM    5  C3  UNL     1      -0.700  -0.846   0.267  1.00  0.00           C  
HETATM    6  O3  UNL     1      -0.375  -2.117  -0.268  1.00  0.00           O  
HETATM    7  C4  UNL     1       0.443   0.057  -0.137  1.00  0.00           C  
HETATM    8  O4  UNL     1       0.557   0.116  -1.525  1.00  0.00           O  
HETATM    9  C5  UNL     1       1.777  -0.502   0.363  1.00  0.00           C  
HETATM   10  O5  UNL     1       1.817  -0.620   1.729  1.00  0.00           O  
HETATM   11  C6  UNL     1       2.877   0.421  -0.165  1.00  0.00           C  
HETATM   12  O6  UNL     1       2.744   1.698   0.371  1.00  0.00           O  
HETATM   13  H1  UNL     1      -2.313   2.746  -0.310  1.00  0.00           H  
HETATM   14  H2  UNL     1      -3.518   1.007  -0.414  1.00  0.00           H  
HETATM   15  H3  UNL     1      -2.822   0.803   1.203  1.00  0.00           H  
HETATM   16  H4  UNL     1      -1.917  -0.423  -1.461  1.00  0.00           H  
HETATM   17  H5  UNL     1      -2.728  -1.704   0.945  1.00  0.00           H  
HETATM   18  H6  UNL     1      -0.784  -0.954   1.347  1.00  0.00           H  
HETATM   19  H7  UNL     1      -0.629  -2.075  -1.225  1.00  0.00           H  
HETATM   20  H8  UNL     1       0.369   1.081   0.260  1.00  0.00           H  
HETATM   21  H9  UNL     1       0.928  -0.748  -1.833  1.00  0.00           H  
HETATM   22  H10 UNL     1       1.970  -1.504  -0.077  1.00  0.00           H  
HETATM   23  H11 UNL     1       1.290   0.057   2.214  1.00  0.00           H  
HETATM   24  H12 UNL     1       3.878  -0.022   0.015  1.00  0.00           H  
HETATM   25  H13 UNL     1       2.758   0.518  -1.263  1.00  0.00           H  
HETATM   26  H14 UNL     1       3.616   2.138   0.378  1.00  0.00           H  
CONECT    1    2   13
CONECT    2    3   14   15
CONECT    3    4    5   16
CONECT    4   17
CONECT    5    6    7   18
CONECT    6   19
CONECT    7    8    9   20
CONECT    8   21
CONECT    9   10   11   22
CONECT   10   23
CONECT   11   12   24   25
CONECT   12   26
END
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SMILES for HMDB0000247 (Sorbitol)

OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
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INCHI for HMDB0000247 (Sorbitol)

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC6H14O6
Average Molecular Weight182.1718
Monoisotopic Molecular Weight182.07903818
IUPAC Name(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol
Traditional NameD-sorbitol
CAS Registry Number50-70-4
SMILES
OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI Identifier
InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
InChI KeyFBPFZTCFMRRESA-JGWLITMVSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentSugar alcohols
Alternative Parents
Substituents
  • Sugar alcohol
  • Monosaccharide
  • Secondary alcohol
  • Polyol
  • Hydrocarbon derivative
  • Primary alcohol
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Health effectOrganoleptic effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Industrial applicationBiological role
Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting Point11 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility2750 mg/mLNot Available
LogP-2.20SANGSTER (1994)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available131.4http://allccs.zhulab.cn/database/detail?ID=AllCCS00000375
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Saliva
  • Urine
Tissue Locations
  • Adipose Tissue
  • Adrenal Medulla
  • Bladder
  • Erythrocyte
  • Eye Lens
  • Fibroblasts
  • Kidney
  • Liver
  • Neuron
  • Placenta
  • Platelet
  • Prostate
  • Retina
Pathways
Normal Concentrations
Abnormal Concentrations
Associated Disorders and Diseases
Disease References
Uremia
  1. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jorres A, Lemke HD, Massy ZA, Passlick-Deetjen J, Rodriguez M, Stegmayr B, Stenvinkel P, Tetta C, Wanner C, Zidek W: Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 2003 May;63(5):1934-43. doi: 10.1046/j.1523-1755.2003.00924.x. [PubMed:12675874 ]
Alzheimer's disease
  1. Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302. [PubMed:8595727 ]
Crohn's disease
  1. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Ulcerative colitis
  1. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Colorectal cancer
  1. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Eosinophilic esophagitis
  1. Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
Associated OMIM IDs
DrugBank IDDB01638
Phenol Explorer Compound IDNot Available
FooDB IDFDB011676
KNApSAcK IDC00001173
Chemspider ID5576
KEGG Compound IDC00794
BioCyc IDSORBITOL
BiGG IDNot Available
Wikipedia LinkSorbitol
METLIN IDNot Available
PubChem Compound5780
PDB IDNot Available
ChEBI ID17924
Food Biomarker OntologyNot Available
VMH IDSBT_D
MarkerDB IDMDB00000120
Good Scents IDNot Available
References
Synthesis ReferenceLiu, Haichao; Luo, Chen. Method for manufacturing sorbitol and mannitol with cellulose. Faming Zhuanli Shenqing Gongkai Shuomingshu (2007), 8pp.
Material Safety Data Sheet (MSDS)Not Available
General References

Enzymes

Enzyme Details
1. Aldose reductase
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Gene Name:
AKR1B1
Uniprot ID:
P15121
Molecular weight:
35853.125
Reactions
Sorbitol + NADP → alpha-D-Glucose + NADPH + Hydrogen Iondetails
Enzyme Details
2. Glucokinase
General function:
Involved in ATP binding
Specific function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Gene Name:
GCK
Uniprot ID:
P35557
Molecular weight:
52191.07
Enzyme Details
3. Hexokinase-3
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK3
Uniprot ID:
P52790
Molecular weight:
99024.56
Enzyme Details
4. Hexokinase-2
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK2
Uniprot ID:
P52789
Molecular weight:
102379.06
Enzyme Details
5. Sorbitol dehydrogenase
General function:
Involved in zinc ion binding
Specific function:
Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).
Gene Name:
SORD
Uniprot ID:
Q00796
Molecular weight:
38324.25
Reactions
Sorbitol + NAD → D-Fructose + NADH + Hydrogen Iondetails
Enzyme Details
6. Alpha-galactosidase A
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
GLA
Uniprot ID:
P06280
Molecular weight:
Not Available
Reactions
Melibiitol + Water → Sorbitol + beta-D-Galactosedetails
Enzyme Details
7. Glycophorin-B
General function:
Not Available
Specific function:
This protein is a minor sialoglycoprotein in erythrocyte membranes
Gene Name:
GYPB
Uniprot ID:
P06028
Molecular weight:
9795.6
Enzyme Details
8. Aldo-keto reductase family 1 member B10
General function:
Not Available
Specific function:
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
Gene Name:
AKR1B10
Uniprot ID:
O60218
Molecular weight:
Not Available
Reactions
Sorbitol + NADP → alpha-D-Glucose + NADPH + Hydrogen Iondetails