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Symbol report for NCOA3

HGNC data for NCOA3

Approved symbol
NCOA3
Approved name

nuclear receptor coactivator 3

Locus type
gene with protein product
HGNC ID
HGNC:7670
Symbol status
Approved
Alias symbols
RAC3
AIB1
ACTR
p/CIP
TRAM-1
CAGH16
TNRC16
KAT13B
bHLHe42
SRC-3
SRC3
Alias names
receptor-associated coactivator 3
thyroid hormone receptor activator molecule 1
Chromosomal location
20q13.12
UCSC
Alliance of Genome Resources
INSDC
AF012108 Curated
CCDS
CCDS13406 Curated
CCDS13407 Curated
CCDS54472 Curated
Bos taurus
NCOA3 VGNC:31921 VGNC
Canis familiaris
NCOA3 VGNC:54658 VGNC
Equus caballus
NCOA3 VGNC:20597 VGNC
Felis catus
NCOA3 VGNC:68432 VGNC
Macaca mulatta
NCOA3 VGNC:75147 VGNC
Mus musculus
Ncoa3 MGI:1276535 Curated
Pan troglodytes
NCOA3 VGNC:6203 VGNC
Rattus norvegicus
Ncoa3 RGD:620109
Sus scrofa
NCOA3 VGNC:96434 VGNC
IUPHAR/BPS Guide to PHARMACOLOGY
TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.
Takeshita A et al. J Biol Chem 1997 Oct;272(44)27629-27634
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW.
J Biol Chem 1997 Oct;272(44)27629-27634
Abstract: Nuclear hormone receptors (NRs) are ligand-dependent transcription factors that regulate target gene transcription. We report the molecular cloning and characterization of a novel human cDNA encoding TRAM-1, a thyroid hormone receptor activator molecule, a approximately 160-kDa protein homologous with SRC-1/TIF2, by far-Western-based expression screening. TRAM-1 binds to thyroid hormone receptor (TR) and other NRs in a ligand-dependent manner and enhances ligand-induced transcriptional activity of TR. The AF-2 region in NRs has been thought to play a critical role in mediating ligand-dependent transactivation by the interaction with coactivators. Surprisingly, TRAM-1 retains strong ligand-dependent interaction with an AF-2 mutant of TR (E457A), while SRC-1 fails to interact with this mutant. Furthermore, we identified a critical TRAM-1 binding site in rat TRbeta1 outside of AF-2, as TRAM-1 shows weak ligand-dependent interaction with a helix 3 ligand binding domain TR mutant (K288A), compared with SRC-1. These results suggest that TRAM-1 is a coactivator that may exhibit its activity by interacting with subdomains of NRs other than the AF-2 region, in contrast to SRC-1/TIF2.
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.
Anzick SL et al. Science 1997 Aug;277(5328)965-968
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS.
Science 1997 Aug;277(5328)965-968
Abstract: Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen-dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.