Drug: (5Z)-7-Oxozeaenol - Cancerrxgene - Genomics of Drug Sensitivity in Cancer

Compound: (5Z)-7-Oxozeaenol

Drug Target: TAK1

Drug Target pathway: Other, kinases

GDSC1

Tissue specific analysis

IC50
AUC

Number of cell lines screened	899
Maximum IC50 (uM)	363
Geometric mean (uM)	2.29
Minimum IC50 (uM)	0.00888
Min screening concentration (uM)	0.0391
Max screening concentration (uM)	10.0

Cell line	TCGA classification	Tissue	Tissue sub-type	IC50	AUC
EoL-1-cell	UNCLASSIFIED	blood	haematopoietic_neoplasm_other	0.008876	0.029889
IGR-37	SKCM	skin	melanoma	0.009736	0.032925
MV-4-11	UNCLASSIFIED	blood	leukemia	0.010896	0.029534
G-MEL	SKCM	skin	melanoma	0.016692	0.059113
SH-4	SKCM	skin	melanoma	0.017782	0.113477
K5	THCA	thyroid	thyroid	0.020292	0.069347
MEL-HO	SKCM	skin	melanoma	0.021720	0.077816
A375	SKCM	skin	melanoma	0.022267	0.063252
MOLM-13	LAML	blood	acute_myeloid_leukaemia	0.025111	0.095286
MMAc-SF	SKCM	skin	melanoma	0.027121	0.106960
OCI-AML2	LAML	blood	acute_myeloid_leukaemia	0.028605	0.046757
M14	SKCM	skin	melanoma	0.030342	0.121583
WM35	SKCM	skin	melanoma	0.035547	0.115094
451Lu	SKCM	skin	melanoma	0.036208	0.121503
BHT-101	THCA	thyroid	thyroid	0.036820	0.118420
SW872	UNCLASSIFIED	soft_tissue	soft_tissue_other	0.042617	0.118771
MDST8	COREAD	digestive_system	large_intestine	0.043055	0.133136
COLO-679	SKCM	skin	melanoma	0.045082	0.156619
K2	SKCM	skin	melanoma	0.051365	0.192653
MONO-MAC-6	LAML	blood	acute_myeloid_leukaemia	0.055516	0.176438
UACC-62	SKCM	skin	melanoma	0.063742	0.169543
SK-MEL-28	SKCM	skin	melanoma	0.068323	0.178226
MZ7-mel	SKCM	skin	melanoma	0.073964	0.197384
C32	SKCM	skin	melanoma	0.076057	0.235017
CP50-MEL-B	SKCM	skin	melanoma	0.092295	0.209621

The Genomics of Drug Sensitivity in Cancer Project is a collaboration between the Cancer Genome Project

at the Wellcome Sanger Institute

(UK) and the Center for Molecular Therapeutics

, Massachusetts General Hospital Cancer Center

(USA). This work is funded by Wellcome

Users have a non-exclusive, non-transferable right to use data files for internal proprietary research and educational purposes, including target, biomarker and drug discovery. Excluded from this licence are use of the data (in whole or any significant part) for resale either alone or in combination with additional data/product offerings, or for provision of commercial services.
Please note: The data files are experimental and academic in nature and are not licensed or certified by any regulatory body. Genome Research Limited provides access to data files on an “as is” basis and excludes all warranties of any kind (express or implied).

https://www.cancerrxgene.org/compound/(5Z)-7-Oxozeaenol/1242/overview/ic50

Genomics of Drug Sensitivity in Cancer

Compound: (5Z)-7-Oxozeaenol

Drug Target: TAK1

Drug Target pathway: Other, kinases

DatasetDatasetsGDSC1: Screened in 96 or 384-well plates with Cyto60 or Resazurin endpointGDSC2 (recommended where available): 1536-well plates with CellTiterGlo endpointSee documentation for more information and screening differences

Tissue specific analysis

DatasetDatasets
GDSC1: Screened in 96 or 384-well plates with Cyto60 or Resazurin endpoint
GDSC2 (recommended where available): 1536-well plates with CellTiterGlo endpoint
See documentation for more information and screening differences