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Structural state
Disorder function
Structural transition
Interaction partner
Type of the data
Regions
Consensus
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DP00086 - Cellular tumor antigen p53
Organism
Homo sapiens
Gene
TP53
(
P53
)
Sequence length
393
Disorder content
87.8%
Cross references
UniProtKB:
P04637
, MobiDB:
P04637
Dataset(s)
Autophagy-related proteins
Cancer-related proteins
Condensates-related proteins
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Entry history
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DP00086r013
Structural state
Term
disorder,
IDPO:00076
Fragment
1 - 93
Evidence
nuclear magnetic resonance spectroscopy evidence used in manual assertion
,
ECO:0006165
Reference
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
Wells M, Tidow H, Rutherford TJ, Markwick P, Jensen MR, Mylonas E, Svergun DI, Blackledge M, Fersht AR.
Proc Natl Acad Sci U S A, 2008
,
pmid:18391200
Statements
Results
"
RDC analysis showed that the isolated domain p53(1–93) was an IDP with two regions of nascent secondary structure.
"
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